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公开(公告)号：US08709316B2
公开(公告)日：2014-04-29
申请号：US12867867
申请日：2009-03-13
IPC分类号： B29C47/38
CPC分类号： B29C31/10 , B01F3/18 , B01F5/246 , B01F15/0234 , B01F15/0276 , B01F2215/0049 , B29C31/02
摘要： A process (2) for manufacturing a shaped article (17), comprising the steps of: dry blending (8) a plurality of different particulated ingredients (11) to form a uniform particle blend; reblending the particle blend by substantially defining a mass flow in a discharge unit (19) including an insert (39, 60) and shaping the particle blend in a part shaping machine (15) to form the shaped article (17).
摘要翻译： 一种用于制造成型制品（17）的方法（2），包括以下步骤：将多种不同的颗粒成分（11）干混（8）以形成均匀的颗粒混合物; 通过在包括插入件（39,60）的排出单元（19）中基本上限定质量流动并在部件成型机（15）中成形该颗粒共混物以形成成型制品（17）来重新悬垂该颗粒混合物。
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公开(公告)号：US20110001265A1
公开(公告)日：2011-01-06
申请号：US12867867
申请日：2009-03-13
CPC分类号： B29C31/10 , B01F3/18 , B01F5/246 , B01F15/0234 , B01F15/0276 , B01F2215/0049 , B29C31/02
摘要： A process (2) for manufacturing a shaped article (17), comprising the steps of: dry blending (8) a plurality of different particulated ingredients (11) to form a uniform particle blend; reblending the particle blend by substantially defining a mass flow in a discharge unit (19) including an insert (39, 60) and shaping the particle blend in a part shaping machine (15) to form the shaped article (17).
摘要翻译： 一种用于制造成型制品（17）的方法（2），包括以下步骤：将多种不同的颗粒成分（11）干混（8）以形成均匀的颗粒混合物; 通过在包括插入件（39,60）的排出单元（19）中基本上限定质量流动并在部件成型机（15）中成形该颗粒共混物以形成成型制品（17）来重新悬垂该颗粒混合物。
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公开(公告)号：US5064582A
公开(公告)日：1991-11-12
申请号：US407840
申请日：1989-09-15
申请人： Tod A. Sutton , Karl V. Jacob , Timothy Lim , Steven P. Sandor
发明人： Tod A. Sutton , Karl V. Jacob , Timothy Lim , Steven P. Sandor
CPC分类号： C08J11/06 , B29B17/00 , B29K2035/00 , C08J2300/10 , Y02W30/62 , Y02W30/701
摘要： A process for recycling and reblending dry, difficult to hydrate polymer fines into a water-swellable fluid absorbent polymer gel is disclosed. The process requires feeding the dry polymer fines into a first mixing zone where they are subjected to spraying with water that at least partially hydrates the fines and mixing, substantially simultaneously with the water contact, at high shear such at the fines are substantial completely hydrated without agglomeration. The hydrated fines are then transported from the first zone into a second mixing zone where blending of the hydrated fines with fresh polymer gel occurs at medium shear such that a substantially uniformly blended product results. The resulting process successfully re-introduces fines into the main product stream wherein the resulting product has high aqueous fluid absorbent capacity and good particulate mechanical integrity.
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公开(公告)号：US08877249B2
公开(公告)日：2014-11-04
申请号：US12595627
申请日：2008-02-28
申请人： Tim D. Cabelka , Akshay Bellare , Ka Chun A. Chan , Tina P. Dasbach , Kacee B. Ender , Karl V. Jacob , Robert E. Scheid, Jr.
发明人： Tim D. Cabelka , Akshay Bellare , Ka Chun A. Chan , Tina P. Dasbach , Kacee B. Ender , Karl V. Jacob , Robert E. Scheid, Jr.
CPC分类号： A61K9/1652 , A61K31/138 , A61K31/55 , Y10T428/2982
摘要： A dosage form for controlled release is produced from a composition comprising a granular material having a mean particle diameter of 150 to 350 micrometers and a compactibility resulting in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa, at least 80 percent of the granular material being a water-soluble cellulose ether, water-soluble cellulose ester, an alkylene oxide homo- or copolymer, or a blend thereof; and an active ingredient.
摘要翻译： 用于控制释放的剂型由包含平均粒径为150至350微米的颗粒材料的组合物和当颗粒材料经受压实时具有至少1.7MPa的拉伸强度的紧凑性的组合物制备 266MPa的压力，至少80％的颗粒材料是水溶性纤维素醚，水溶性纤维素酯，烯化氧均聚物或共聚物或其共混物; 和活性成分。
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公开(公告)号：US20100151038A1
公开(公告)日：2010-06-17
申请号：US12595627
申请日：2008-02-28
申请人： Tim D . Cabelka , Akshay Bellare , Ka Chun A. Chan , Tina P. Dasbach , Kacee B. Ender , Karl V. Jacob , Robert E. Scheid, JR.
发明人： Tim D . Cabelka , Akshay Bellare , Ka Chun A. Chan , Tina P. Dasbach , Kacee B. Ender , Karl V. Jacob , Robert E. Scheid, JR.
CPC分类号： A61K9/1652 , A61K31/138 , A61K31/55 , Y10T428/2982
摘要： A granular material which has a mean particle diameter of 150 to 800 micrometers; and an unsettled bulk density of 0.1 to 0.35 g/cm3 and/or a compactibility which results in a compact with a tensile strength of at least 1.7 MPa when the granular material is subjected to a compaction pressure of 266 MPa; and wherein the main component of the granular material is a cellulose derivative or an alkylene oxide homo- or copolymer or a blend thereof is useful for preparing dosage forms with a controlled release profile.
摘要翻译： 平均粒径为150〜800微米的粒状材料; 并且当颗粒材料经受266MPa的压实压力时，未稳定的堆积密度为0.1至0.35g / cm 3和/或致密度，其导致抗拉强度至少为1.7MPa的致密性; 并且其中所述颗粒材料的主要组分是纤维素衍生物或烯化氧均聚物或共聚物或其共混物可用于制备具有受控释放曲线的剂型。
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