公开(公告)号：US06319507B1

公开(公告)日：2001-11-20

申请号：US09431742

申请日：1999-11-01

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K914

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

Abstract translation: 由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药​​物等输送载体。 优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的， 约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。 各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。 还描述了制造方法。

公开(公告)号：US08025892B2

公开(公告)日：2011-09-27

申请号：US10017259

申请日：2001-11-12

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K31/14 ,  A61K8/02 ,  A61K9/14 ,  A61K9/50 ,  C11D1/62

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of hydrophobic liquid so that the gelling agent solution cools rapidly and good quality gel particles coalesce in the cold hydrophobic liquid stream. The cold hydrophobic liquid stream can be contained in a conduit so that the cold hydrophobic liquid stream moves past the discharge orifice and exerts a force on hot solution in the discharge orifice, the force acting to withdraw the hot solution from the discharge orifice. Optionally, the gel particles can be crushable gel beads 10 formed of an agar complex providing cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Various active agents 16 may be bound to restraining polymer 14, for, example ascorbic acid, lactic acid or papain.

Abstract translation: 可以通过形成热胶凝剂的水溶液，并将热胶凝剂溶液通过排出孔排出到冷流动的疏水液体中，使得胶凝剂溶液快速冷却，并且优质的凝胶颗粒 在冷疏水性液体流中聚结。 冷疏水性液体流可以包含在导管中，使得冷的疏水性液体流移动通过排出孔，并且在排出孔中的热溶液上施加力，该力用于从排出孔抽出热溶液。 任选地，凝胶颗粒可以是由琼脂复合物形成的可压碎凝胶珠10，其提供用于局部递送生物或化妆活性剂的化妆品，药​​物等递送载体。 优选的琼脂珠10是具有抑制聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸 酸或木瓜蛋白酶。