公开(公告)号：US06319507B1

公开(公告)日：2001-11-20

申请号：US09431742

申请日：1999-11-01

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K914

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Crushable gel beads 10 formed of an agar complex provide novel cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Entrapped in and dispersed randomly throughout each agar bead 10 is a water-soluble, preferably polar, restraining polymer 14, preferably a quaternized cationic polymer, such as polyquaternium 24 or steardimonium hydroxyethylcellulose. Various active agents 16 may be bound to restraining polymer 14, for example ascorbic acid, lactic acid or papain. Methods of manufacture are also described.

Abstract translation: 由琼脂复合物形成的可破碎的凝胶珠10提供用于局部递送生物或化妆活性剂的新型化妆品，药​​物等输送载体。 优选的琼脂珠10是具有抑制性聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。包埋并随机分散在每个琼脂珠10中是水溶性的，优选极性的， 约束聚合物14，优选季铵化阳离子聚合物，例如聚季铵盐24或羟乙基纤维素。 各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸或木瓜蛋白酶。 还描述了制造方法。

公开(公告)号：US08025892B2

公开(公告)日：2011-09-27

申请号：US10017259

申请日：2001-11-12

Applicant: Pascal E. Delrieu ,  Li Ding

Inventor： Pascal E. Delrieu ,  Li Ding

IPC: A61K31/14 ,  A61K8/02 ,  A61K9/14 ,  A61K9/50 ,  C11D1/62

CPC classification number: A61K8/042 ,  A61K8/025 ,  A61K8/11 ,  A61K8/365 ,  A61K8/645 ,  A61K8/676 ,  A61K8/73 ,  A61K8/731 ,  A61K8/735 ,  A61K2800/56 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of hydrophobic liquid so that the gelling agent solution cools rapidly and good quality gel particles coalesce in the cold hydrophobic liquid stream. The cold hydrophobic liquid stream can be contained in a conduit so that the cold hydrophobic liquid stream moves past the discharge orifice and exerts a force on hot solution in the discharge orifice, the force acting to withdraw the hot solution from the discharge orifice. Optionally, the gel particles can be crushable gel beads 10 formed of an agar complex providing cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Various active agents 16 may be bound to restraining polymer 14, for, example ascorbic acid, lactic acid or papain.

Abstract translation: 可以通过形成热胶凝剂的水溶液，并将热胶凝剂溶液通过排出孔排出到冷流动的疏水液体中，使得胶凝剂溶液快速冷却，并且优质的凝胶颗粒 在冷疏水性液体流中聚结。 冷疏水性液体流可以包含在导管中，使得冷的疏水性液体流移动通过排出孔，并且在排出孔中的热溶液上施加力，该力用于从排出孔抽出热溶液。 任选地，凝胶颗粒可以是由琼脂复合物形成的可压碎凝胶珠10，其提供用于局部递送生物或化妆活性剂的化妆品，药​​物等递送载体。 优选的琼脂珠10是具有抑制聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸 酸或木瓜蛋白酶。

公开(公告)号：US20240341483A1

公开(公告)日：2024-10-17

申请号：US18300768

申请日：2023-04-14

Applicant: Li Ding

Inventor： Li Ding

IPC: A47C7/46

CPC classification number: A47C7/462

Abstract: A lumbar pillow that can move with the load bearing of the waist in 3D, comprising the lumbar pillow body, the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism; the spring central axis mechanism comprises the upper bottom plate, the spring and the lower bottom plate, the upper bottom plate is arranged in the middle of the rear end of the lumbar pillow body, the upper bottom plate is provided with a spring, and the other end of the spring is provided with a lower bottom plate; the middle part of the rear end of the lumbar pillow body is provided with a spring central axis mechanism, so that the upper bottom plate will be supported on the backrest of the seat, when the waist leans on the lumbar pillow, the spring will support the lumbar pillow.

公开(公告)号：US09633143B2

公开(公告)日：2017-04-25

申请号：US14110703

申请日：2012-04-05

Applicant: Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

Inventor： Milton Santano Elias Carrasco ,  Daniel Akwera Shihundu ,  Billy Siu Fai Chan ,  Steven Kin-Shing Cheng ,  Christian Grant Milne ,  Guanggui Pei ,  Darren Earl Brown ,  Li Ding

IPC: G06G7/48 ,  G06F17/50

CPC classification number: G06F17/5009 ,  G06F17/5095

Abstract: A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

公开(公告)号：US20130138093A1

公开(公告)日：2013-05-30

申请号：US13686952

申请日：2012-11-28

Applicant: Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

Inventor： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

IPC: A61B18/20 ,  A61F2/14

CPC classification number: A61F2/14 ,  A61B18/20 ,  A61F2/142 ,  A61F2/1451 ,  A61F2/147 ,  A61F2/16 ,  A61F9/008 ,  A61L27/16 ,  A61L27/18 ,  A61L27/52 ,  B29D11/00355 ,  B29D11/00461 ,  B29D11/023 ,  B29K2083/00 ,  B29K2105/0061 ,  C08J7/12 ,  C08J7/123 ,  C08J2333/14 ,  C08J2339/06 ,  C08J2383/04 ,  G02B1/041 ,  G02C7/022 ,  G02C2202/12 ,  G02C2202/14

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract translation: 一种光学装置，包括具有已经用激光照射的选择区域的光学水凝胶，所述激光具有0.01nJ至50nJ的脉冲能量和600nm至900nm的波长。 照射区域的特征在于折射率的正变化为0.01至0.06，并且表现出很小的或没有散射损失。 用亲水性单体制备光学水凝胶。

公开(公告)号：US20130026359A1

公开(公告)日：2013-01-31

申请号：US13634190

申请日：2011-04-22

Applicant: Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

Inventor： Sumio Kumashiro ,  Wenjian Sun ,  Li Ding

IPC: H01J49/26 ,  H01J49/04 ,  H01J49/16

CPC classification number: H01J49/10 ,  G01N27/622 ,  H01J49/066 ,  H01J49/161 ,  H01J49/164 ,  H01J49/165 ,  H01J49/24

Abstract: The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.

Abstract translation: 本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。 气态中性分子通过解吸法在大气压下解吸。 然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。 然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

公开(公告)号：US20110049352A1

公开(公告)日：2011-03-03

申请号：US12552476

申请日：2009-09-02

Applicant: Li Ding ,  Wenjian Sun

Inventor： Li Ding ,  Wenjian Sun

IPC: H01J49/16 ,  H01J49/26

CPC classification number: H01J49/162 ,  H01J49/0463 ,  H01J49/165

Abstract: This invention relates to a desorpton/ionization source operated under ambient conditions for direct analysis of solid or liquid samples on a surface. The source comprises of a laser desorption system and a UV/electrospray combined ionization system. The source is suitable for simultaneously ionizing samples with different polarity in a complex mixture. At the same time, the compact design of the source with multiple channels can maintain the level of local concentration of the analyte ions inside the source for higher efficiency of sample ionization and introduction.

Abstract translation: 本发明涉及在环境条件下操作的用于在表面上直接分析固体或液体样品的解吸/离子源。 该源包括激光解吸系统和UV /电喷雾组合电离系统。 该源适用于在复杂混合物中同时电离不同极性的样品。 同时，具有多个通道的源的紧凑设计可以保持源内的分析物离子的局部浓度水平，以提高样品电离和引入的效率。

公开(公告)号：US07897916B2

公开(公告)日：2011-03-01

申请号：US10598194

申请日：2005-02-23

Applicant: Michael Sudakov ,  Li Ding

Inventor： Michael Sudakov ,  Li Ding

IPC: H01J49/42

CPC classification number: H01J49/40 ,  H01J49/004 ,  H01J49/423

Abstract: A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, −V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.

Abstract translation: 串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。 离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V1，V2）以提供离散DC电平以及用于将DC电源连接/断开至少两个电极的多个快速电子开关（409） 填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

公开(公告)号：US07893401B2

公开(公告)日：2011-02-22

申请号：US12158458

申请日：2006-12-20

Applicant: Li Ding

Inventor： Li Ding

IPC: H01J49/04

CPC classification number: H01J49/062 ,  H01J49/0481 ,  H01J49/164

Abstract: A mass spectrometer has a pulsed ion source, a first ion trap (10) for trapping ions generated by the pulsed ion source and for locating trapped ions for subsequent ejection from the first ion trap. A pulse of cooling gas is introduced into the first ion trap (10) at a peak pressure suitable for enabling the first ion trap (10) to trap ions. A turbomolecular pump (17) reduces the pressure of cooling gas before the trapped ions are ejected from the first ion trap (1) towards a second ion trap (20) for analysis. The pulsed ion source has a sample plate (14) which forms an end wall of the first ion trap (10).

Abstract translation: 质谱仪具有脉冲离子源，第一离子阱（10），用于捕获由脉冲离子源产生的离子，并用于定位捕获的离子用于随后从第一离子阱排出。 将冷却气体的脉冲以适于使第一离子阱（10）捕获离子的峰值压力引入到第一离子阱（10）中。 涡轮分子泵（17）在被捕获的离子从第一离子阱（1）向第二离子阱（20）排出之前降低冷却气体的压力，用于分析。 脉冲离子源具有形成第一离子阱（10）的端壁的样品板（14）。

公开(公告)号：US07789910B2

公开(公告)日：2010-09-07

申请号：US11948298

申请日：2007-11-30

Applicant: Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

Inventor： Wayne H. Knox ,  Li Ding ,  Jay F. Kunzler ,  Dharmendra Jani ,  Candido D. Pinto

IPC: A61F2/16

CPC classification number: A61F2/1613 ,  A61B18/20 ,  A61F2/14 ,  A61F2/16 ,  A61F2/1627 ,  A61F2/1635 ,  B29D11/00461 ,  B29D11/023 ,  C08J7/12 ,  C08J7/123 ,  G02C2202/14

Abstract: A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.

Abstract translation: 用于改变光学聚合物材料的折射率的方法。 该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。 照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。 该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。 本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异 光学，聚合材料。