公开(公告)号：US06949354B2

公开(公告)日：2005-09-27

申请号：US10149114

申请日：2000-12-07

申请人： Pascal Villa ,  Michel Delaage ,  Toni Williamson ,  Christopher Henderson

发明人： Pascal Villa ,  Michel Delaage ,  Toni Williamson ,  Christopher Henderson

IPC分类号： A61K45/00 ,  A61P25/16 ,  A61P25/28 ,  C12N5/06 ,  C12N5/08 ,  C12N5/10 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  C12Q1/00 ,  A01K67/027

CPC分类号： G01N33/5058

摘要： The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

摘要翻译： 本发明涉及用于筛选和/或鉴定对神经元具有生物活性的化合物的组合物和方法。 本发明还涉及神经元的分离和培养，对所述分离的神经元诱导病理状况的方法以及用于实施所述方法的试剂盒。 本发明可用于实验研究，药物发现，药物开发等。 更具体地，本发明可用于鉴定和/或表征和/或改善在神经元上有活性并可用于治疗神经系统疾病的化合物。

公开(公告)号：US07372626B2

公开(公告)日：2008-05-13

申请号：US10276245

申请日：2001-05-10

申请人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

发明人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

IPC分类号： G02B21/26

CPC分类号： G02B21/241 ,  G02B21/26

摘要： The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output. It comprises a spacer (43) fixed relative to the objective (15) and having a support surface (45) on the support (19), said support surface being located proximate to the observation axis, so that said spacer (43) is adapted to maintain, on the observation axis, a constant distance between the objective (15) and the observation surface (29), during a relative displacement between the support (19) and the observation axis. The invention is useful for rapid analysis of cell samples.

摘要翻译： 本发明涉及用于观察或分析支持物上的样品的方法和装置。 更具体地说，它涉及用于顺序观察布置在公共板（19）上的几个样品的装置，其包括用于观察用于定位板（19）的台（17）的物镜（15），所述台（17）适于确保板 （19）和垂直于观察轴的平面中的观察轴，同时沿着观察轴线释放垂直位移，用于照亮样本的装置（21）和用于获取物镜上的图像的装置（23,25） 15）输出。 它包括相对于物镜（15）固定并且在支撑件（19）上具有支撑表面（45）的间隔件（43），所述支撑表面位于观察轴线附近，使得所述间隔物（43）适于 在支撑件（19）和观察轴线之间的相对位移期间，在观察轴线上保持物镜（15）和观察表面（29）之间的恒定距离。 本发明可用于细胞样品的快速分析。