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    Methods for screening compounds active on neurons
    1.
    发明授权
    Methods for screening compounds active on neurons 失效
    筛选对神经元有活性的化合物的方法

    公开(公告)号：US06949354B2

    公开(公告)日：2005-09-27

    申请号：US10149114

    申请日：2000-12-07

    申请人： Pascal Villa ,  Michel Delaage ,  Toni Williamson ,  Christopher Henderson

    发明人： Pascal Villa ,  Michel Delaage ,  Toni Williamson ,  Christopher Henderson

    IPC分类号： A61K45/00 ,  A61P25/16 ,  A61P25/28 ,  C12N5/06 ,  C12N5/08 ,  C12N5/10 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  C12Q1/00 ,  A01K67/027

    CPC分类号： G01N33/5058

    摘要： The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.

    摘要翻译： 本发明涉及用于筛选和/或鉴定对神经元具有生物活性的化合物的组合物和方法。 本发明还涉及神经元的分离和培养，对所述分离的神经元诱导病理状况的方法以及用于实施所述方法的试剂盒。 本发明可用于实验研究，药物发现，药物开发等。 更具体地，本发明可用于鉴定和/或表征和/或改善在神经元上有活性并可用于治疗神经系统疾病的化合物。

    Device for sequential observation of samples and methods using same
    2.
    发明授权
    Device for sequential observation of samples and methods using same 有权
    用于顺序观察样品的装置和使用其的方法

    公开(公告)号：US07372626B2

    公开(公告)日：2008-05-13

    申请号：US10276245

    申请日：2001-05-10

    申请人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

    发明人： Pascal Villa ,  Michel Delaage ,  Toni Williamson

    IPC分类号： G02B21/26

    CPC分类号： G02B21/241 ,  G02B21/26

    摘要： The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output. It comprises a spacer (43) fixed relative to the objective (15) and having a support surface (45) on the support (19), said support surface being located proximate to the observation axis, so that said spacer (43) is adapted to maintain, on the observation axis, a constant distance between the objective (15) and the observation surface (29), during a relative displacement between the support (19) and the observation axis. The invention is useful for rapid analysis of cell samples.

    摘要翻译： 本发明涉及用于观察或分析支持物上的样品的方法和装置。 更具体地说，它涉及用于顺序观察布置在公共板（19）上的几个样品的装置，其包括用于观察用于定位板（19）的台（17）的物镜（15），所述台（17）适于确保板 （19）和垂直于观察轴的平面中的观察轴，同时沿着观察轴线释放垂直位移，用于照亮样本的装置（21）和用于获取物镜上的图像的装置（23,25） 15）输出。 它包括相对于物镜（15）固定并且在支撑件（19）上具有支撑表面（45）的间隔件（43），所述支撑表面位于观察轴线附近，使得所述间隔物（43）适于 在支撑件（19）和观察轴线之间的相对位移期间，在观察轴线上保持物镜（15）和观察表面（29）之间的恒定距离。 本发明可用于细胞样品的快速分析。

    DEVICE AND PROCESS FOR THE FORMATION OF MICRODEPOSITIONS
    5.
    发明申请
    DEVICE AND PROCESS FOR THE FORMATION OF MICRODEPOSITIONS 审中-公开
    用于形成微结构的装置和方法

    公开(公告)号：US20110132109A1

    公开(公告)日：2011-06-09

    申请号：US12936959

    申请日：2009-04-09

    申请人： Michel Delaage

    发明人： Michel Delaage

    IPC分类号： B01L3/02

    CPC分类号： B01L3/0244 ,  B01J2219/00373 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01L3/0251 ,  B01L3/5082 ,  B01L2400/0688

    摘要： Methods and equipment for forming multiple micro-depositions on surfaces from a single sample for sample analysis are provided. The device for the formation of micro-depositions of a liquid sample, includes a plurality of reservoirs, each with a through-hole, and needles, each with a tip mounted for movement through and beyond the hole, and a control member ensuring the controlled and regular formation of micro-depositions according to a defined profile.

    摘要翻译： 提供了用于在单个样品的表面上形成多个微沉积物以用于样品分析的方法和设备。 用于形成液体样品的微沉积的装置包括多个具有通孔的储存器和针，每个储存器具有安装成用于移动并穿过孔的尖端，以及确保受控制的控制构件的控制构件 并根据定义的轮廓规则形成微沉积物。

    Device for positioning a plate used for analyzing samples on an examination device
    8.
    发明授权
    Device for positioning a plate used for analyzing samples on an examination device 失效
    用于定位用于在检查装置上分析样品的板的装置

    公开(公告)号：US07072105B2

    公开(公告)日：2006-07-04

    申请号：US10501233

    申请日：2003-01-09

    申请人： Michel Delaage

    发明人： Michel Delaage

    IPC分类号： G02B21/26

    CPC分类号： G02B21/26

    摘要： The invention relates to a device for positioning a biological sample analysis plate on an observation device comprising an observation lens and a chassis having a plate support assembly [20]. This assembly comprises a first frame [21] and a second frame [22] able to slide in a plane perpendicular to the observation axis, assumed to be vertical, with the first and second frames each able to move in a direction perpendicular to the direction of movement of the other frame; and a third frame [23] supported by the second frame [22] by means [30] used to maintain said third frame in a plane perpendicular to the observation axis, while leaving the movement free in a vertical plane.

    摘要翻译： 本发明涉及一种用于将生物样品分析板定位在观察装置上的装置，包括观察透镜和具有板支撑组件的底架[20]。 该组件包括第一框架[21]和第二框架[22]，其能够垂直于观察轴线的平面滑动，假设为垂直的，第一和第二框架每个都能够沿垂直于该方向的方向移动 的另一个框架的运动; 以及第三框架[23]，其由用于将所述第三框架保持在垂直于观察轴线的平面中的装置[30]支撑，同时使移动在垂直平面中自由。