公开(公告)号：US08574831B2

公开(公告)日：2013-11-05

申请号：US11933747

申请日：2007-11-01

申请人： Pascale Alfons Rosa Dehertogh ,  Kurt Hertogs ,  Brendan Larder ,  Dechao Wang

发明人： Pascale Alfons Rosa Dehertogh ,  Kurt Hertogs ,  Brendan Larder ,  Dechao Wang

IPC分类号： C12Q1/70 ,  C12Q1/68

CPC分类号： G06F19/18 ,  G06F19/28

摘要： The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.

摘要翻译： 本发明提供与HIV药物的表型抗性相关的HIV-1逆转录酶和/或蛋白酶基因的新突变，突变组合或突变分布。 更具体地，本发明涉及HIV的目标群体的基因型表征的使用以及该信息随后与表型解释的相关性，以将病毒突变特征与耐药性相关联。 本发明还涉及在数据库，药物开发，即药物设计，药物修饰，治疗和治疗设计，临床管理和诊断分析中利用本发明的突变特征的方法。

公开(公告)号：US07206699B2

公开(公告)日：2007-04-17

申请号：US09836477

申请日：2001-04-18

申请人： Brendan Larder ,  Stuart Bloor ,  Kurt Hertogs ,  Pascale Alfons Rosa Dehertogh ,  Rudy Jean Marc Mortier

发明人： Brendan Larder ,  Stuart Bloor ,  Kurt Hertogs ,  Pascale Alfons Rosa Dehertogh ,  Rudy Jean Marc Mortier

IPC分类号： G06F19/00

CPC分类号： C12Q1/6876 ,  C12Q1/703 ,  C12Q1/707 ,  C12Q2600/156 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24 ,  G06F19/28

摘要： The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.

摘要翻译： 本发明涉及通过将基因型信息与表型谱相关联来测量耐药性的方法。 在一个实施方案中，描述了一种用于解释基因型信息的方法，其中从患者样品产生遗传密码，从产生的遗传基因获得已知或怀疑在发展对一种或多种药物的抗性发展中起作用的突变的列表 对于先前具有与所述一种或多种药物相似的突变的样品，询问基因型数据库，所述样品的表型位于表型数据库中，基于位于所述表型数据库中的所有实施例确定抑制的平均变化 确定一种或多种适合于治疗特定指征的药物的灵敏度分布。