公开(公告)号：US20120295321A1

公开(公告)日：2012-11-22

申请号：US13509299

申请日：2010-11-12

申请人： Patricia Ann vanKuyk ,  Ronald Peter de Vries ,  Jacob Visser ,  Arthur Franciscus Johannes Ram ,  Cornelis Antonius Maria Jacobus Johannes van den Hondel ,  Evy Battaglia ,  Diana Alexandra Vivas Duarte

发明人： Patricia Ann vanKuyk ,  Ronald Peter de Vries ,  Jacob Visser ,  Arthur Franciscus Johannes Ram ,  Cornelis Antonius Maria Jacobus Johannes van den Hondel ,  Evy Battaglia ,  Diana Alexandra Vivas Duarte

IPC分类号： C12P7/10 ,  C12N1/19 ,  C12N1/15

CPC分类号： C07K14/38 ,  Y02E50/16

摘要： The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.

摘要翻译： 本发明涉及从粗碳源生产生物燃料，蛋白质，肽和其他增值化合物。 发明人确定了编码新戊糖转运蛋白的基因，特别是L-阿拉伯糖和/或D-木糖的转运蛋白。 通过xlnR和araR调节黑曲霉基因有助于鉴定这些基因及其底物特异性。 提供新的戊糖转运蛋白及其编码核酸。 还提供了表达转运蛋白的宿主细胞（以上）及其工业应用，例如在生物燃料生产中。

公开(公告)号：US20090047701A1

公开(公告)日：2009-02-19

申请号：US11813189

申请日：2005-12-23

申请人： Arthur Franciscus Johannes Ram ,  Robbert Antonius Damveld ,  Mark Arentshorst ,  Patricia Ann van Kuyk ,  Cornelis Antonius Maria Jacobus Johannes van den Hondel

发明人： Arthur Franciscus Johannes Ram ,  Robbert Antonius Damveld ,  Mark Arentshorst ,  Patricia Ann van Kuyk ,  Cornelis Antonius Maria Jacobus Johannes van den Hondel

IPC分类号： C12Q1/02 ,  C12N1/14 ,  C12N1/15 ,  C07H21/00 ,  C07K14/00

CPC分类号： C12Q1/18 ,  G01N2333/37

摘要： The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall. It also relates to a kit for screening for antifungal agents which disturb cell wall biogenesis.

摘要翻译： 本发明涉及一种真菌，其基本上不产生对参与细胞壁应激反应的基因的转录具有调节活性的功能性蛋白质。 它还涉及用于筛选抗真菌剂的方法，特别是靶向细胞壁的抗真菌剂。 它还涉及用于筛选干扰细胞壁生物发生的抗真菌剂的试剂盒。