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公开(公告)号：US07737160B2
公开(公告)日：2010-06-15
申请号：US11675183
申请日：2007-02-15
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4745 , A61K31/4743 , A61K31/4741
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US08273736B2
公开(公告)日：2012-09-25
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D495/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07202363B2
公开(公告)日：2007-04-10
申请号：US10899168
申请日：2004-07-26
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： C07D491/04 , C07D421/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有式的化合物
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公开(公告)号：US20100069371A1
公开(公告)日：2010-03-18
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , C07D495/04 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US08188083B2
公开(公告)日：2012-05-29
申请号：US12215338
申请日：2008-06-26
申请人： David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
发明人： David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
IPC分类号： A61K31/50 , C07D237/26
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译： 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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公开(公告)号：US20090270402A1
公开(公告)日：2009-10-29
申请号：US12215338
申请日：2008-06-26
申请人： David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
发明人： David J. Calderwood , Dominique F. Bonafoux , Andrew Burchat , Ping Ding , Kristine E. Frank , Michael Z. Hoemann , Kelly D. Mullen , Heather M. Davis
IPC分类号： A61K31/4985 , C07D487/04 , C07D513/04 , A61K31/433 , A61P25/28 , A61K31/5025
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译： 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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公开(公告)号：US20080161341A1
公开(公告)日：2008-07-03
申请号：US11973147
申请日：2007-10-05
申请人： David J. Calderwood , Kristine E. Frank , David W. Borhani , Heather M. Davis , Nathan S. Josephsohn , Barbara S. Skinner
发明人： David J. Calderwood , Kristine E. Frank , David W. Borhani , Heather M. Davis , Nathan S. Josephsohn , Barbara S. Skinner
IPC分类号： A61K31/437 , C07D513/04 , C07D498/04 , A61K31/4439 , A61K31/424 , A61K31/429
CPC分类号： C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译： 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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公开(公告)号：US07790741B2
公开(公告)日：2010-09-07
申请号：US11973147
申请日：2007-10-05
申请人： David J. Calderwood , Kristine E. Frank , David W. Borhani , Heather M. Davis , Nathan S. Josephsohn , Barbara S. Skinner
发明人： David J. Calderwood , Kristine E. Frank , David W. Borhani , Heather M. Davis , Nathan S. Josephsohn , Barbara S. Skinner
IPC分类号： A61K31/437 , A61K31/4184 , A61K31/424 , A61K31/429 , C07D487/04 , C07D513/04 , C07D498/04
CPC分类号： C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译： 本发明涉及新的式（I）化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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