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公开(公告)号：US07737160B2
公开(公告)日：2010-06-15
申请号：US11675183
申请日：2007-02-15
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4745 , A61K31/4743 , A61K31/4741
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US20100076051A1
公开(公告)日：2010-03-25
申请号：US12625958
申请日：2009-11-25
申请人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman
发明人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman
IPC分类号： A61K31/403 , A61P35/04
CPC分类号： C07D401/12 , C07D209/46 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US08273736B2
公开(公告)日：2012-09-25
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , A61K31/55 , A61K31/5377 , A61K31/496 , C07D495/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US20120122924A1
公开(公告)日：2012-05-17
申请号：US13294318
申请日：2011-11-11
申请人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Rick F. Clark , Michael Michaelides , Chris Tse
发明人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Rick F. Clark , Michael Michaelides , Chris Tse
IPC分类号： A61K31/4709 , A61K31/47 , C07D487/00 , A61P25/28 , A61P1/00 , A61P3/10 , A61P35/00 , A61P9/10 , A61P37/02 , A61P11/06 , A61P11/00 , C07D217/16 , A61P19/10
CPC分类号： C07D217/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.
摘要翻译： 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。
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公开(公告)号：US07202363B2
公开(公告)日：2007-04-10
申请号：US10899168
申请日：2004-07-26
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： C07D491/04 , C07D421/04
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有式的化合物
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公开(公告)号：US20120122842A1
公开(公告)日：2012-05-17
申请号：US13294303
申请日：2011-11-11
申请人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
发明人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
IPC分类号： A61K31/541 , C07D491/048 , C07D401/14 , C07D401/12 , C07D495/04 , C07D403/14 , C07D405/12 , C07D403/12 , C07D417/12 , A61K31/4035 , A61K31/496 , A61K31/4439 , A61K31/501 , A61K31/4155 , A61P9/12 , A61P9/04 , A61P9/00 , A61P13/12 , A61P9/10 , A61P11/06 , A61P15/10 , A61P15/00 , A61P13/10 , A61P25/00 , A61P29/00 , A61P25/28 , A61P25/16 , A61P19/02 , A61P19/08 , A61P1/00 , A61P17/06 , A61P35/00 , A61P35/04 , A61P31/12 , A61P31/04 , A61P3/10 , A61P25/24 , A61P25/18 , A61P25/08 , A61P35/02 , A61P11/00 , C07D209/44
CPC分类号： C07D209/44 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
摘要： Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.
摘要翻译： 公开了抑制NAMPT活性的化合物，含有该化合物的组合物和治疗其中NAMPT表达的疾病的方法。 公开了抑制ROCK活性的化合物，含有化合物的组合物和治疗ROCK表达疾病的方法。
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公开(公告)号：US06294573B1
公开(公告)日：2001-09-25
申请号：US09492567
申请日：2000-01-27
申请人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
发明人： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
IPC分类号： C07C25537
CPC分类号： C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
摘要： Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：US20100069371A1
公开(公告)日：2010-03-18
申请号：US12623026
申请日：2009-11-20
申请人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
发明人： Patrick Betschmann , Andrew F. Burchat , David J. Calderwood , Michael L. Curtin , Steven K. Davidsen , Heather M. Davis , Robin R. Frey , Howard R. Heyman , Gavin C. Hirst , Peter Hrnciar , Michael R. Michaelides , Melanie A. Muckey , Kelly D. Mullen , Paul Rafferty , Carol K. Wada
IPC分类号： A61K31/4365 , C07D495/04 , A61K31/55 , A61K31/5377 , A61K31/496
CPC分类号： A61K31/4743 , A61K31/4741 , A61K31/4745 , C07D491/04 , C07D495/04 , Y02A50/401
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07129260B2
公开(公告)日：2006-10-31
申请号：US10858934
申请日：2004-06-02
申请人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman
发明人： Michael L. Curtin , Steven K. Davidsen , Robin R. Frey , Howard R. Heyman , James H. Holms , Michael Michaelides , Douglas H. Steinman
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D401/12 , C07D209/46 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号：US09302989B2
公开(公告)日：2016-04-05
申请号：US13294303
申请日：2011-11-11
申请人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
发明人： Michael L. Curtin , Bryan K. Sorensen , Howard R. Heyman , Richard F. Clark , Kevin R. Woller , Omar J. Shah , Michael Michaelides , Chris Tse , Anil Vasudevan , Helmut Mack , Todd M. Hansen , Ramzi Sweis , Marina A. Pliushchev
IPC分类号： A01N43/38 , A61K31/40 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/10 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D403/12 , C07D403/14 , C07D405/12
CPC分类号： C07D209/44 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
摘要： Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.
摘要翻译： 公开了抑制NAMPT活性的1,3-二氢-2H-异吲哚化合物，含有化合物的组合物和使用该化合物治疗NAMPT表达的疾病的方法，例如癌症，代谢紊乱和炎症性疾病。 公开了抑制ROCK活性的1,3-二氢-2H-异吲哚化合物，含有该化合物的组合物和使用该化合物治疗ROCK表达的疾病的方法，例如癌症，心血管疾病和炎症性疾病。
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