公开(公告)号：US20060014813A1

公开(公告)日：2006-01-19

申请号：US10997752

申请日：2004-11-24

申请人： Patrick Connelly ,  Gregory Connelly ,  Andrew Magee

发明人： Patrick Connelly ,  Gregory Connelly ,  Andrew Magee

IPC分类号： A61K31/42 ,  A61K31/415 ,  C07D231/10 ,  C07D261/06

CPC分类号： C07D231/12 ,  C07D231/14 ,  C07D261/08 ,  C07D275/02 ,  C07D307/33 ,  C07D307/58

摘要： The invention relates to a class of compounds that reacts with and neutralizes a reactive oxygen species, such as a free oxygen radical, in a patient and which can then be regenerated back to their original reactive chemical form by a naturally occurring enzyme in said patient. These compounds are useful to treat diseases in a patient characterized by a reactive oxygen species. Moreover, because these compounds can be regenerated back to their original, reactive chemical state in vivo, a single molecule can neutralize multiple molecules of the reactive species. This allows for the use of lower dosages for the treatment of disease, as compared to compounds presently used to treat that same disease, thus avoiding side effects associated with higher dosages.

摘要翻译： 本发明涉及一类在患者中反应并中和活性氧物质例如游离氧基团的化合物，然后可以通过所述患者中的天然存在的酶将其再生回到其原始的反应性化学形式。 这些化合物可用于治疗以活性氧为特征的患者中的疾病。 此外，由于这些化合物可以在体内再生回到其原始的反应性化学状态，所以单个分子可以中和反应性物质的多个分子。 与目前用于治疗相同疾病的化合物相比，这允许使用较低剂量用于治疗疾病，因此避免与较高剂量相关的副作用。