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公开(公告)号：US20060014813A1
公开(公告)日：2006-01-19
申请号：US10997752
申请日：2004-11-24
申请人： Patrick Connelly , Gregory Connelly , Andrew Magee
发明人： Patrick Connelly , Gregory Connelly , Andrew Magee
IPC分类号： A61K31/42 , A61K31/415 , C07D231/10 , C07D261/06
CPC分类号： C07D231/12 , C07D231/14 , C07D261/08 , C07D275/02 , C07D307/33 , C07D307/58
摘要： The invention relates to a class of compounds that reacts with and neutralizes a reactive oxygen species, such as a free oxygen radical, in a patient and which can then be regenerated back to their original reactive chemical form by a naturally occurring enzyme in said patient. These compounds are useful to treat diseases in a patient characterized by a reactive oxygen species. Moreover, because these compounds can be regenerated back to their original, reactive chemical state in vivo, a single molecule can neutralize multiple molecules of the reactive species. This allows for the use of lower dosages for the treatment of disease, as compared to compounds presently used to treat that same disease, thus avoiding side effects associated with higher dosages.
摘要翻译： 本发明涉及一类在患者中反应并中和活性氧物质例如游离氧基团的化合物，然后可以通过所述患者中的天然存在的酶将其再生回到其原始的反应性化学形式。 这些化合物可用于治疗以活性氧为特征的患者中的疾病。 此外，由于这些化合物可以在体内再生回到其原始的反应性化学状态，所以单个分子可以中和反应性物质的多个分子。 与目前用于治疗相同疾病的化合物相比，这允许使用较低剂量用于治疗疾病，因此避免与较高剂量相关的副作用。
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2.发明申请HETEROCYCLIC COMPOUNDS AND USES THEREOF AS D-ALANYL-D-ALANINE LIGASE INHIBITORS 审中-公开杂环化合物及其作为D-氨基-L-氨基酸碱基抑制剂的用途公开(公告)号：US20080090847A1
公开(公告)日：2008-04-17
申请号：US11951214
申请日：2007-12-05
申请人： Scott Moe , Paul Ala , Emanuele Perola , Carlos Faerman , Jacob Clement , Janid Ali , Paul Will , Salvatore Marchese , Andrew Magee , John Gazzaniga , Christopher Faraday , Manuel Navia , Patrick Connelly
发明人： Scott Moe , Paul Ala , Emanuele Perola , Carlos Faerman , Jacob Clement , Janid Ali , Paul Will , Salvatore Marchese , Andrew Magee , John Gazzaniga , Christopher Faraday , Manuel Navia , Patrick Connelly
IPC分类号： A61K31/495 , A61P33/00 , C07D475/04 , C12N9/99
CPC分类号： C07D401/12 , C07D471/04 , C07D475/08 , C07D487/04
摘要： The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.
摘要翻译： 本发明基于发现具有例如抗菌性质的新类型的杂环化合物。 D-Ala-D-Ala连接酶是细菌细胞壁合成中的关键途径酶。 该化合物可以结合并抑制酶D-Ala-D-Ala连接酶。 新化合物的活性与其交叉细菌细胞膜的能力相结合，使其适合用作抗菌药物或其他抗菌药物。
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3.发明申请STRUCTURE-BASED DRUG DESIGN METHODS FOR IDENTIFYING D-ALA-D-ALA LIGASE INHIBITORS AS ANTIBACTERIAL DRUGS 审中-公开用于鉴定D-ALA-D-ALA LIGASE抑制剂作为抗菌药物的基于结构的药物设计方法公开(公告)号：US20070207512A1
公开(公告)日：2007-09-06
申请号：US11461678
申请日：2006-08-01
申请人： Paul Ala , Janid Ali , Carlos Faerman , James Griffith , Andrew Magee , Scott Moe , Manuel Navia , Emanuele Perola , Patrick Connelly
发明人： Paul Ala , Janid Ali , Carlos Faerman , James Griffith , Andrew Magee , Scott Moe , Manuel Navia , Emanuele Perola , Patrick Connelly
IPC分类号： C12Q1/25
CPC分类号： C12N9/93
摘要： The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors.
摘要翻译： 本发明基于以下发现，即使在不存在酶的底物的情况下，某些小分子也可以结合D-Ala-D-Ala连接酶的ATP结合位点，并且可以引起类似于酶结构的构象变化 其在ATP和底物与酶结合后发生。 不希望受任何理论束缚，据信这种构象变化是酶活化或抑制所必需的。 从该发现获得的信息使得能够鉴定酶的活性位点中的关键相互作用以及抑制剂的设计和优化。
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公开(公告)号：US20070127855A1
公开(公告)日：2007-06-07
申请号：US10561932
申请日：2004-06-28
申请人： Ian Smith , John Griffiths , Patrick Connelly , Paul Brassington
发明人： Ian Smith , John Griffiths , Patrick Connelly , Paul Brassington
CPC分类号： B65D33/004 , B65D31/04 , B65D33/22
摘要： The invention relates to plastic bags and sack for use especially in the food and pharmaceutical industries. The bag (2) comprises inner and outer bag sections (4, 14) which are joined at least at an upper portion in a manner which allows them to be separated when required, such as by heat sealing. The outer bag section (14) may be provided with a mouth (10) through which the inner bag section can be withdrawn when required. Alternatively, the outer bag section may be peeled away from the inner bag section. The inner bag section is heat sealed after filling with contents to retain the contents in the inner portion. The heat sealing step also serves to secure the bag sections together as above. The inner bag section is preferably provided with a closeable mouth (132) separate from the end by which it is filled, through which the contents may be dispensed.
摘要翻译： 本发明涉及特别用于食品和制药行业的塑料袋和袋。 袋子（2）包括内部和外部袋部分（4,14），它们至少在上部部分以允许它们在需要时被分离的方式，例如通过热封。 外袋部分（14）可以设置有口（10），当需要时可以将内袋部分抽出。 或者，外袋部分可以从内袋部分剥离。 内袋部分在填充内容物之后被热密封，以将内容物保持在内部。 热封步骤还用于将袋部分固定在一起如上。 内袋部优选地设置有与其被填充的端部分离的可闭合的口（132），通过该口可以分配内容物。
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公开(公告)号：US20060089385A1
公开(公告)日：2006-04-27
申请号：US11147524
申请日：2005-06-08
申请人： Yong Cui , Maura Murphy , Kirk Dinehart , Patricia Hurter , Patrick Connelly
发明人： Yong Cui , Maura Murphy , Kirk Dinehart , Patricia Hurter , Patrick Connelly
IPC分类号： A61K31/445
CPC分类号： A61K38/07 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K31/497 , A61K45/06
摘要： Forms and formulations of VX-950 and uses thereof.
摘要翻译： VX-950的形式和配方及其用途。
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公开(公告)号：US20050043761A1
公开(公告)日：2005-02-24
申请号：US10946026
申请日：2004-09-21
申请人： Patrick Connelly , Michael Weiner , Thomas Foster
发明人： Patrick Connelly , Michael Weiner , Thomas Foster
CPC分类号： A61N1/08 , A61N1/37 , A61N1/3718 , A61N1/375
摘要： A medical device containing a device for connecting the medical device to a substrate, for furnishing electrical impulses from the medical device to the substrate, for ceasing the furnishing of electrical impulses to the substrate, for receiving pulsed radio frequency fields, for transmitting and receiving optical signals, and for protecting the substrate and the medical device from currents induced by the pulsed radio frequency fields. The medical device contains a control circuit comprised of a parallel resonant frequency circuit.
摘要翻译： 一种医疗装置，包括用于将医疗装置连接到基板的装置，用于从医疗装置向基板提供电脉冲，用于停止向基板提供电脉冲，用于接收脉冲射频场，用于发射和接收光学 信号，并且用于保护衬底和医疗装置免受由脉冲射频场引起的电流。 医疗装置包含由并联谐振频率电路构成的控制电路。
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公开(公告)号：US20050113874A1
公开(公告)日：2005-05-26
申请号：US10795747
申请日：2004-03-08
CPC分类号： G01R33/285 , A61N1/086 , G01R33/288 , G01R33/4804 , Y10T428/24322 , Y10T428/24331
摘要： An electromagnetic shield has a first patterned or apertured layer having non-conductive materials and conductive material and a second patterned or apertured layer having non-conductive materials and conductive material. The conductive material may be a metal, a carbon composite, or a polymer composite. The non-conductive materials in the first patterned or apertured layer may be randomly located or located in a predetermined segmented pattern such that the non-conductive materials in the first patterned or apertured layer are located in a predetermined segmented pattern with respect to locations of the non-conductive materials in the second patterned or apertured layer.
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8.发明申请公开(公告)号：US20050113873A1
公开(公告)日：2005-05-26
申请号：US10795741
申请日：2004-03-08
CPC分类号： G01R33/285 , A61N1/086 , G01R33/288 , G01R33/4804 , Y10T428/24322 , Y10T428/24331
摘要： An electromagnetic shield has a first patterned or apertured layer having non-conductive materials and conductive material and a second patterned or apertured layer having non-conductive materials and conductive material. The conductive material may be a metal, a carbon composite, or a polymer composite. The non-conductive materials in the first patterned or apertured layer may be randomly located or located in a predetermined segmented pattern such that the non-conductive materials in the first patterned or apertured layer are located in a predetermined segmented pattern with respect to locations of the non-conductive materials in the second patterned or apertured layer.
摘要翻译： 电磁屏蔽具有具有非导电材料和导电材料的第一图案化或有孔层，以及具有非导电材料和导电材料的第二图案化或有孔层。 导电材料可以是金属，碳复合材料或聚合物复合材料。 第一图案化或有孔层中的非导电材料可以是随机位置或位于预定的分段图案中，使得第一图案化或有孔层中的非导电材料相对于 在第二图案或多孔层中的非导电材料。
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公开(公告)号：US5518403A
公开(公告)日：1996-05-21
申请号：US217987
申请日：1994-03-25
CPC分类号： A62C99/0081 , G09B9/00
摘要： A fire fighting trainer for use in training fire fighters about a ceiling rollover fire. This trainer includes a chamber with a ceiling and includes a burner head subassembly and includes a burner control subassembly. The burner head subassembly has a fuel gas inlet pipe and an adjacent combustion air inlet pipe to produce an air/gas mixture which creates a flame at the ceiling. The burner control subassembly selectively increases the fuel gas flow to make the produced flame have a ceiling rollover effect.
摘要翻译： 用于训练消防员关于天花板翻车火的消防教练。 该培训者包括具有天花板的室，并且包括燃烧器头部组件，并且包括燃烧器控制子组件。 燃烧器头部组件具有燃料气体入口管和相邻的燃烧空气入口管，以产生在天花板处产生火焰的空气/气体混合物。 燃烧器控制子组件选择性地增加燃料气体流量，使得产生的火焰具有天花板翻转效果。
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公开(公告)号：US20120158080A1
公开(公告)日：2012-06-21
申请号：US13408933
申请日：2012-02-29
CPC分类号： A61N1/375 , A61N1/086 , A61N1/3718
摘要： A medical device containing a device for connecting the medical device to a substrate, for furnishing electrical impulses from the medical device to the substrate, for ceasing the furnishing of electrical impulses to the substrate, for receiving pulsed radio frequency fields, for transmitting and receiving optical signals, and for protecting the substrate and the medical device from currents induced by the pulsed radio frequency fields. The medical device contains a control circuit comprised of a parallel resonant frequency circuit.
摘要翻译： 一种医疗装置，包括用于将医疗装置连接到基板的装置，用于从医疗装置向基板提供电脉冲，用于停止向基板提供电脉冲，用于接收脉冲射频场，用于发射和接收光学 信号，并且用于保护衬底和医疗装置免受由脉冲射频场引起的电流。 医疗装置包含由并联谐振频率电路构成的控制电路。
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