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22 条记录 (耗时 0.025 秒)

    3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors
    2.
    发明申请
    3-oxo-1, 3-dihydro-indazole-2-carboxylic acid amide derivatives as phospholipase inhibitors 审中-公开

    公开(公告)号：US20060211755A1

    公开(公告)日：2006-09-21

    申请号：US10544910

    申请日：2004-03-25

    申请人： Patrick Eacho ,  Patricia Foxworthy-Mason ,  Ho-Shen Lin ,  Jose Lopez ,  Marian Mosior ,  Michael Richett

    发明人： Patrick Eacho ,  Patricia Foxworthy-Mason ,  Ho-Shen Lin ,  Jose Lopez ,  Marian Mosior ,  Michael Richett

    IPC分类号： A61K31/416 ,  C07D231/56

    CPC分类号： C07D231/56 ,  C07D405/12 ,  C07D409/12

    摘要： The present invention provides a compound of formula I (1) wherein; R, is selected from the group consisting of C5-C13alkyl; C,—C,2haloalkyl, C4C,2alkenyl, C4-C12alkynyl, or C,—C5alkylcycloalkyl, C3-C8cycloalkyl, C, C5alkylheterocyclic, and aryl, wherein the, cycloalkyl, cycloalkenyl, heterocyclic and aryl substituents are optionally substituted with one to three substituents independently selected from C,—C8a)kyl, C,—C8haloalkyl, ′C2-CBalkenyl, C2-C8a)kynyl, phenyl, benzyl, hydroxy, C,—C5 alkoxy, (C}12)m000C,—Csalkyl, (CH2)mNRaRb, and C,C4alkylcycloalkyl; wherein W and Rb are independently selected from hydrogen, C,CBalkyl, C2-CBalkenyl, C2-CBalkynyl, and C,—C5alkylcycloalkyl; R2 is hydrogen; R3, R4, R5, and R6, are independently selected from hydrogen, C,—C12alkyl, C2C,2haloalkyl, C2-C,2 alkenyl, C2-C12alkynyl, C,—C12alkylaryl, C,—C12alkylcyclohexyl, C, C12alkylcyclopentyl, C,—C12alkylheterocyclic, (CH2)m000H, (CH2)mC0(C,—C,o)alkyl, (CH2)m COO(C,—C,o)alkyl, (CH2)mCOO(C1-C,o)alkylaryl, C,—C,oalkylamino, halo, (CH2)mCONH2, (CH2)rCONRaRb, phenyl, or aryl wherein each of the phenyl or aryl groups is optionally substituted with one to three groups independently selected from CBalkyl, C,—CBhaloalkyl, C2-CBalkenyl, CZCBalkynyl, phenyl, benzyl, hydroxy, C,—C5 alkoxy, (CH2)m000C,—Csalkyl, and C,—C4alkylcycloalkyl; and wherein m is 0, 1, 2, or 3; R7 is selected from the group consisting of hydrogen, C,—Cloalkyl, C,C,ohaloalkyl, C2-C,oalkenyl, C2-C,oalkynyl, C,—C6alkylaryl, C,—C6alkylcyclohexyl, C—C6aikylcyclopentyl, C,—C6alkylheterocyclic, or aryl; or a pharmaceutically acceptable sallvate thereofi together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase-mediated diseases.

    Method and grinding machine for dressing of a grinding tool
    6.
    发明授权
    Method and grinding machine for dressing of a grinding tool 有权
    研磨机的修整方法和研磨机

    公开(公告)号：US08147296B2

    公开(公告)日：2012-04-03

    申请号：US12109627

    申请日：2008-04-25

    申请人： Jose Lopez

    发明人： Jose Lopez

    IPC分类号： B24B1/00

    CPC分类号： B24B53/085 ,  B23F5/04 ,  B23F23/1225 ,  B24B53/12

    摘要： The invention relates to a method and machine for the dressing of a grinding tool (1), which has at least one tooth-shaped profile (2) with a first flank (3) and an opposing second flank (4). A disk-shaped dressing tool (5) used for dressing of the grinding tool (2) has a first abrasive area (6) and a second abrasive area (7). To allow a faster and thus more economical dressing of the grinding tool, the first abrasive area (6) contacts the first flank (3) and the second abrasive area (7) contacts the second flank (4) simultaneously, and the disc-shaped dressing tool (5) and/or the grinding tool (1) are pivoted relatively to another around an axis (A) being arranged perpendicular to the axis of rotation (C) of the grinding tool (1), so that both flanks (3, 4) are dressed simultaneously.

    摘要翻译： 本发明涉及一种用于修整研磨工具（1）的方法和机器，该研磨工具具有至少一个具有第一侧面（3）和相对的第二侧面（4）的齿形轮廓（2）。 用于磨削工具（2）的盘形修整工具（5）具有第一研磨区域（6）和第二磨料区域（7）。 为了允许磨削工具更快且因此更经济地修整，第一研磨区域（6）接触第一侧面（3）并且第二磨料区域（7）同时接触第二侧面（4），并且盘形 修整工具（5）和/或磨削工具（1）相对于另一个围绕垂直于研磨工具（1）的旋转轴线（C）布置的轴线（A）枢转，使得两侧面 ，4）同时穿着。

    Execution monitoring system for financial instruments
    7.
    发明申请
    Execution monitoring system for financial instruments 审中-公开
    金融工具执行监控系统

    公开(公告)号：US20070244792A1

    公开(公告)日：2007-10-18

    申请号：US11403725

    申请日：2006-04-13

    申请人： Frederic Couperier ,  Christopher Dacre-Wright ,  Jose Lopez

    发明人： Frederic Couperier ,  Christopher Dacre-Wright ,  Jose Lopez

    IPC分类号： G06Q40/00

    CPC分类号： G06Q40/04

    摘要： A computerized method of monitoring compliance comprises: (a) receiving information regarding an order for a financial instrument which was executed at a first one of a plurality of automated trading centers against a protected quotation of said first trading center, the information including at least an order time at which the order was placed, an identifier sufficient to identify said financial instrument, a volume of the order, an identifier sufficient to identify said first trading center; and a price of the order; (b) receiving market data for said financial instrument, said market data including each protected quotation for the financial instrument at each of the plurality of automated trading centers during a grace period extending from a second time, which is prior to said order time, to said order time; (c) comparing said protected quotation of said first trading center at the order time to each other protected quotation for the financial instrument at the order time, and: (1) if none of the other protected quotations is a better quotation than said protected quotation, identifying the order as compliant; (2) if any of the other protected quotations is a better quotation than said protected quotation, searching the market data for the financial instrument during said grace period, and: (i) if at any time during the grace period none of the other protected quotations had a better quotation than said protected quotation, identifying the order as compliant, and, if not, identifying the order as an order for which compliance has not been demonstrated.

    摘要翻译： 一种监测合规性的计算机化方法包括：（a）接收关于在多个自动交易中心的第一个执行的金融工具的订单的信息针对所述第一交易中心的受保护的报价，所述信息至少包括 发出订单的订单时间，足以识别所述金融工具的标识符，订单量，足以识别所述第一交易中心的标识符; 和订单的价格; （b）接收所述金融工具的市场数据，所述市场数据包括在从所述订单时间之前的第二时间延伸的宽限期期间在所述多个自动交易中心中的每一个的金融工具的每个受保护报价到 说订单时间 （c）在命令时间将所述第一交易中心的受保护报价与金融工具的相互保护报价进行比较，以及：（1）如果其他受保护报价中没有一个比所述受保护报价更好的报价 ，将订单确定为合规; （2）如果任何其他受保护的报价是比所述受保护的报价更好的报价，则在所述宽限期内搜索金融工具的市场数据，以及：（i）如果在宽限期内的任何时间没有其他受保护的报价 引用报价比所述受保护的报价更好，将订单确定为合规，如果不是，则将订单确定为尚未证明合规性的订单。

    AUTOMATIC PERSONAL IDENTIFIABLE INFORMATION REMOVAL FROM AUDIO
    8.
    发明申请
    AUTOMATIC PERSONAL IDENTIFIABLE INFORMATION REMOVAL FROM AUDIO 有权

    公开(公告)号：US20220084521A1

    公开(公告)日：2022-03-17

    申请号：US17456270

    申请日：2021-11-23

    申请人： Raju Arvind ,  Jose Lopez ,  Georg Stemmer

    发明人： Raju Arvind ,  Jose Lopez ,  Georg Stemmer

    IPC分类号： G10L15/22

    摘要： This disclosure describes systems, methods, and devices related to automatic personal identifiable information (PII) removal. A system may detect a sound signal received from a vicinity of a machine during the operation of the machine. The system may perform speech detection to detect a segment of the sound signal that comprises a speech signal. The system may modify the sound signal at the segment of the sound signal by performing a segment replacement mechanism. The system may generate a filtered sound signal to be used for monitoring the operation of the machine.

    FLUID SAMPLING SYSTEM
    9.
    发明申请
    FLUID SAMPLING SYSTEM 有权
    流体采样系统

    公开(公告)号：US20130000392A1

    公开(公告)日：2013-01-03

    申请号：US13521760

    申请日：2011-01-11

    申请人： Jose Lopez ,  Michel Lepitre

    发明人： Jose Lopez ,  Michel Lepitre

    IPC分类号： G01N1/10

    CPC分类号： G01N1/2035 ,  G01N2001/2071

    摘要： A fluid sampling system for collecting a fluid sample, the sampling system comprising a detachable sampling device having a recipient, an entrance valve for controlling entry of a fluid into the recipient, an exit valve for controlling exit of the fluid from the recipient, and a data storage device for storing data related to the fluid sample.

    摘要翻译： 一种用于收集流体样品的流体采样系统，所述采样系统包括具有接收器的可拆卸采样装置，用于控制流体进入接收器的入口阀，用于控制流体从接收器排出的出口阀，以及 用于存储与流体样本有关的数据的数据存储装置。

    Test socket
    10.
    发明申请
    Test socket 有权
    测试插座

    公开(公告)号：US20070032128A1

    公开(公告)日：2007-02-08

    申请号：US11482644

    申请日：2006-07-07

    申请人： Jose Lopez ,  Dennis Shell ,  Mathew Gilk

    发明人： Jose Lopez ,  Dennis Shell ,  Mathew Gilk

    IPC分类号： H05K1/00

    CPC分类号： G01R1/0466

    摘要： An improved test socket for use in testing integrated circuits. The test socket includes a housing having one or more slots formed therein. Contacts can be received within respective slots and maintained therein with rear ends of the contacts in engagement with traces on a load board. Mounting is accomplished by means of a pair of elastomers, and the elastomers maintain each contact such that, when the front end of a contact is engaged by the lead or pad of the device to be tested and urged into its corresponding slot, an arcuate surface at a rear end of each contact rolls across its corresponding trace with virtually no translational or rotational sliding.

    摘要翻译： 用于测试集成电路的改进的测试插座。 测试插座包括其中形成有一个或多个槽的壳体。 触头可以在相应的插槽内容纳并保持在其中，触头的后端与负载板上的迹线接合。 通过一对弹性体实现安装，并且弹性体保持每个触点，使得当接触件的前端被被测试装置的引线或焊盘接合并被推入其相应的槽时，弓形表面 每个接触件的后端在其对应的轨迹上滚动，实际上没有平移或旋转滑动。