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    Method for clustering signals in spectra
    1.
    发明授权
    Method for clustering signals in spectra 有权
    光谱信号聚类方法

    公开(公告)号：US07860685B2

    公开(公告)日：2010-12-28

    申请号：US11040493

    申请日：2005-01-20

    申请人： Patrick Ho ,  Edward J. Gavin

    发明人： Patrick Ho ,  Edward J. Gavin

    IPC分类号： G01N30/00

    CPC分类号： H01J49/0036

    摘要： Methods for processing spectra are disclosed. The method includes obtaining a plurality of spectra, each spectrum in the plurality of spectra comprising a signal including a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived from time-of-flight or mass-to-charge ratio. Then, a signal cluster is formed by clustering signals from the plurality of spectra with time-of-flights, mass-to-charge ratios, or values derived from time-of-flights or mass-to-charge ratios that are within a window that is defined using an expected signal width value.

    摘要翻译： 公开了处理光谱的方法。 该方法包括获得多个光谱，多个光谱中的每个光谱包括包括作为飞行时间的函数的信号强度，质荷比或从飞行时间导出的值的信号 或质荷比。 然后，通过使来自多个频谱的信号聚集来自飞行中的时间，质荷比或从窗口内的飞行时间或质量 - 荷载比导出的值来形成信号簇 这是使用期望的信号宽度值定义的。

    Variable width digital filter for time-of-flight mass spectrometry
    3.
    发明授权
    Variable width digital filter for time-of-flight mass spectrometry 有权
    可变宽度数字滤波器，用于飞行时间质谱

    公开(公告)号：US06586728B1

    公开(公告)日：2003-07-01

    申请号：US09569158

    申请日：2000-05-11

    申请人： Edward J. Gavin ,  Leonid Braginsky

    发明人： Edward J. Gavin ,  Leonid Braginsky

    IPC分类号： H01J4926

    CPC分类号： H01J49/40

    摘要： A method and system of detecting mass to charge ratio of ions. The method includes producing charged ions in a vacuum, accelerating the charged ions in an electric field into a free flight tube and detecting the charged ions at a detector associated with the free flight tube. A control system selects a bandwidth for filtering a signal produced by the detector and the signal produced by the detector is then filtered with a variable width digital filter based upon the selected bandwidth. The bandwidth for filtering the signal may be selected from a look-up table within the control system based upon the mass to charge ratio of an ion of interest. Alternatively, a peak bandwidth within the signal produced by the detector may be determined and the signal produced by the detector may then be filtered with the variable width digital filter based upon the determined peak bandwidth.

    摘要翻译： 一种检测离子质荷比的方法和系统。 该方法包括在真空中产生带电离子，将电场中的带电离子加速到自由飞行管中，并在与自由飞行管相关联的检测器处检测带电离子。 控制系统选择用于对由检测器产生的信号进行滤波的带宽，然后基于所选择的带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。 用于过滤信号的带宽可以根据感兴趣的离子的质量与电荷比从控制系统内的查找表中选择。 或者，可以确定由检测器产生的信号内的峰值带宽，然后基于所确定的峰值带宽，用可变宽度数字滤波器对由检测器产生的信号进行滤波。

    Method for calibrating a mass spectrometer
    6.
    发明授权
    Method for calibrating a mass spectrometer 失效
    校准质谱仪的方法

    公开(公告)号：US06580071B2

    公开(公告)日：2003-06-17

    申请号：US10194452

    申请日：2002-07-11

    申请人： Scot R. Weinberger ,  Edward J. Gavin ,  Michael G. Youngquist

    发明人： Scot R. Weinberger ,  Edward J. Gavin ,  Michael G. Youngquist

    IPC分类号： A01J4940

    CPC分类号： H01J49/40 ,  H01J49/0009

    摘要： A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.

    摘要翻译： 公开了一种用于校准飞行时间质谱仪的方法。 该方法包括确定飞行时间值或从样品基板上的多个不同可寻址位置中的每一个处的校准物质的飞行时间值得到的值。 然后，衬底上的可寻址位置之一被识别为参考可寻址位置。 然后使用飞行时间值或从飞行时间值导出的值，为基板上的各个可寻址位置计算多个校正因子。