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    Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
    1.
    发明申请
    Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods 审中-公开
    含有视网膜友好赋形剂的治疗眼用组合物及相关方法

    公开(公告)号：US20050250737A1

    公开(公告)日：2005-11-10

    申请号：US11091977

    申请日：2005-03-28

    申请人： Patrick Hughes ,  Laurent Delahaye ,  Michele Boix ,  James Chang ,  Robert Lyons

    发明人： Patrick Hughes ,  Laurent Delahaye ,  Michele Boix ,  James Chang ,  Robert Lyons

    IPC分类号： A61K9/00 ,  A61K31/573 ,  A61K31/724 ,  A61K47/36

    CPC分类号： A61K9/0048 ,  A61K31/573 ,  A61K47/36 ,  A61K47/40

    摘要： Pharmaceutical compositions suitable for administration into the interior of an eye of a person or animal are described. The present compositions include one or more components which are effective in providing a reduced toxicity relative to existing intraocular ophthalmic compositions. The present compositions include one or more therapeutic agents in amounts effective in providing a desired therapeutic effect when placed in an eye, and one or more retinal friendly excipients that have a reduced toxicity relative to benzyl alcohol or polysorbate 80. In certain compositions, the excipient component of the compositions comprises one or more cyclodextrins or cyclodextrin derivatives. Methods of using the compositions to treat ocular conditions are also described.

    摘要翻译： 描述适于施用于人或动物的眼睛内部的药物组合物。 本发明组合物包括一种或多种有效提供相对于现有眼内眼用组合物的毒性降低的成分。 本发明的组合物包含一种或多种治疗剂，其用量在置于眼中时可提供所需的治疗效果，以及一种或多种视黄醛友好的赋形剂，其相对于苯甲醇或聚山梨酸酯80具有降低的毒性。在某些组合物中，赋形剂 组合物的组分包含一种或多种环糊精或环糊精衍生物。 还描述了使用组合物治疗眼睛病症的方法。

    Oil-in-water method for making polymeric implants containing a hypotensive lipid
    2.
    发明授权
    Oil-in-water method for making polymeric implants containing a hypotensive lipid 有权
    用于制造含有低血压脂质的聚合物植入物的水包油法

    公开(公告)号：US08722097B2

    公开(公告)日：2014-05-13

    申请号：US11371118

    申请日：2006-03-08

    申请人： James Chang ,  Patrick Hughes ,  Chin-Ming Chang

    发明人： James Chang ,  Patrick Hughes ,  Chin-Ming Chang

    IPC分类号： A61K9/50 ,  B01J13/02 ,  B01J13/04

    CPC分类号： A61K31/5575 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/1694 ,  A61K31/165 ,  A61K47/34 ,  B01J13/04 ,  B01J13/06

    摘要： Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.

    摘要翻译： 生物相容的微粒包括眼科活性的环状脂质组分和可生物降解的聚合物，当放置在结膜下空间中时，有效地促进环状脂质成分延长眼睛部分的时间。 环状脂质组分可与可生物降解的聚合物基质相结合，例如两种可生物降解聚合物的基质。 或者，环状脂质组分可以被聚合物组分包封。 本发明的微粒包括水包油乳化微粒。 结膜下施用的微粒可用于治疗或减少眼部疾病如青光眼或年龄相关性黄斑变性的至少一种症状。

    Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
    4.
    发明授权
    Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems 有权
    制备α-2激动剂聚合物药物递送系统的水包油法

    公开(公告)号：US07589057B2

    公开(公告)日：2009-09-15

    申请号：US11395019

    申请日：2006-03-31

    申请人： James Chang ,  Patrick Hughes

    发明人： James Chang ,  Patrick Hughes

    IPC分类号： A61K31/27 ,  A61K31/535

    CPC分类号： A61K31/4166

    摘要： Biocompatible microparticles include an ophthalmically active alpha-2 adrenergic receptor agonist and a biodegradable polymer. The microparticles include oil-in-water emulsified microparticles which can be used to treat an ocular condition, such as glaucoma.

    摘要翻译： 生物相容性微粒包括眼科活性α-2肾上腺素能受体激动剂和可生物降解的聚合物。 微粒包括可用于治疗眼部疾病如青光眼的水包油乳化微粒。

    Memantine intravitreal implants
    6.
    发明申请
    Memantine intravitreal implants 审中-公开
    美金刚玻璃体内植入物

    公开(公告)号：US20050244473A1

    公开(公告)日：2005-11-03

    申请号：US11117879

    申请日：2005-04-29

    申请人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

    发明人： Patrick Hughes ,  Lon Spada ,  Hiroshi Sugimoto ,  Wendy Blanda ,  James Chang

    IPC分类号： A61K9/00 ,  A61K31/13 ,  A61F2/00

    CPC分类号： A61K9/0051

    摘要： Biocompatible intraocular implants include an anti-excitotoxic agent and a biodegradable polymer that is effective to facilitate release of the anti-excitotoxic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.

    摘要翻译： 生物相容性眼内植入物包括抗兴奋性毒性剂和可生物降解的聚合物，其有效促进抗兴奋性毒性剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生，例如视网膜损伤，包括青光眼和增生性玻璃体视网膜病变。

    Methods for treating ocular conditions with cyclic lipid containing microparticles
    7.
    发明申请
    Methods for treating ocular conditions with cyclic lipid containing microparticles 有权
    用含脂质的微粒治疗眼部病症的方法

    公开(公告)号：US20060246145A1

    公开(公告)日：2006-11-02

    申请号：US11371118

    申请日：2006-03-08

    申请人： James Chang ,  Patrick Hughes ,  Chin-Ming Chang

    发明人： James Chang ,  Patrick Hughes ,  Chin-Ming Chang

    IPC分类号： A61K9/50 ,  B01J13/04 ,  B01J13/02 ,  A61K9/16

    CPC分类号： A61K31/5575 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/1694 ,  A61K31/165 ,  A61K47/34 ,  B01J13/04 ,  B01J13/06

    摘要： Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.

    摘要翻译： 生物相容的微粒包括眼科活性的环状脂质组分和可生物降解的聚合物，当放置在结膜下空间中时，有效地促进环状脂质成分延长眼睛部分的时间。 环状脂质组分可与可生物降解的聚合物基质相结合，例如两种可生物降解聚合物的基质。 或者，环状脂质组分可以被聚合物组分包封。 本发明的微粒包括水包油乳化微粒。 结膜下施用的微粒可用于治疗或减少眼部疾病如青光眼或年龄相关性黄斑变性的至少一种症状。

    LOW IMMUNOGENICITY CORTICOSTEROID COMPOSITIONS
    8.
    发明申请
    LOW IMMUNOGENICITY CORTICOSTEROID COMPOSITIONS 审中-公开
    低免疫球蛋白组合物

    公开(公告)号：US20070224278A1

    公开(公告)日：2007-09-27

    申请号：US11741366

    申请日：2007-04-27

    申请人： Robert Lyons ,  Michael Robinson ,  James Chang ,  Sam Lam ,  John Trogden ,  Scott Whitcup

    发明人： Robert Lyons ,  Michael Robinson ,  James Chang ,  Sam Lam ,  John Trogden ,  Scott Whitcup

    IPC分类号： A61K9/14 ,  A61K31/56

    CPC分类号： A61K9/0019 ,  A61K9/0048 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/715 ,  A61K47/02 ,  A61K47/34 ,  A61K47/36 ,  A61K47/40

    摘要： Triamcinolone compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes or into a joint are provided. Such compositions can include triamcinolone particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 80,000 cps to about 300,000 cps. In a most preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 280,000 cps t a shear rate of 0.1/second at 25° C. The compositions advantageously suspend the triamcinolone particles for prolonged periods of time.

    摘要翻译： 提供了曲安奈德组合物，以及使用这种组合物的方法，其可用于注射到人眼玻璃体或关节中。 这样的组合物可以包括以治疗有效量存在的曲安奈德颗粒，粘度诱导组分和水性载体组分。 组合物在0.1 /秒的剪切速率下具有至少约10cps或约100cps的粘度。 在优选的实施方案中，粘度在约80,000cps至约300,000cps的范围内。 在最优选的实施方案中，在25℃下，粘度为约140,000cps至约280,000cps，剪切速率为0.1 /秒。组合物有利地将曲安奈德颗粒悬浮较长时间。

    Ophthalmic visualization compositions and methods of using same
    9.
    发明申请
    Ophthalmic visualization compositions and methods of using same 审中-公开
    眼科可视化组合物及其使用方法

    公开(公告)号：US20070218007A1

    公开(公告)日：2007-09-20

    申请号：US11378506

    申请日：2006-03-17

    申请人： James Chang ,  Robert Lyons

    发明人： James Chang ,  Robert Lyons

    IPC分类号： A61K49/00

    CPC分类号： A61K9/10 ,  A61K9/0048 ,  A61K9/107 ,  A61K47/26 ,  A61K47/38 ,  A61K47/44 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0071

    摘要： Compositions and methods useful for at least assisting in visualizing vitreous bodies of eyes of humans or animals are provided. Such compositions include a contrast component and a carrier component and are substantially free of any therapeutic agent effective to have pharmacological activity in an eye in which the composition is placed. Methods of using such compositions as visualization devices are also provided.

    摘要翻译： 提供了用于至少辅助人类或动物的眼睛的玻璃体视觉化的组合物和方法。 这样的组合物包括造影剂组分和载体组分，并且基本上没有任何有效地在其中放置组合物的眼睛中具有药理活性的治疗剂。 还提供了使用这些组合物作为可视化装置的方法。