公开(公告)号：US5532219A

公开(公告)日：1996-07-02

申请号：US042658

申请日：1993-04-05

申请人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

发明人： Patrick L. McGeer ,  Nobua Harada ,  Horoshi Kimura ,  Edith G. McGeer ,  Michael Schulzer

IPC分类号： A61K31/145 ,  A61K31/185 ,  A61K31/426 ,  A61K31/13

CPC分类号： A61K31/426 ,  A61K31/145 ,  A61K31/185

摘要： This invention pertains to the novel use of 4,4'-diaminodiphenylsulfone and its didextrose sulfonate derivative and other closely related sulfones in the prevention and treatment of dementia (Alzheimer's disease). A method of preventing and treating dementia in a human being suffering from dementia which comprises administering to the human being a therapeutic amount of a substance selected from the group consisting of 4,4'-diaminodiphenylsulfone, its didextrose sulfonate derivative, and sulfoxone, sulfetrone and thiazolsulfone, and therapeutically acceptable salts thereof.

摘要翻译： 本发明涉及4,4'-二氨基二苯砜及其二葡萄糖磺酸衍生物及其它密切相关的砜在预防和治疗痴呆症（阿尔茨海默病）中的新用途。 一种预防和治疗患有痴呆症的人的痴呆症的方法，其包括向所述人施用治疗量的选自下组的物质：4,4'-二氨基二苯基砜，其二葡聚糖磺酸酯衍生物和砜酮，磺基和 噻唑砜及其可治疗的盐。