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1.发明授权公开(公告)号：US08409607B2
公开(公告)日：2013-04-02
申请号：US12029425
申请日：2008-02-11
申请人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
发明人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
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2.发明授权公开(公告)号：US08404267B2
公开(公告)日：2013-03-26
申请号：US12029424
申请日：2008-02-11
申请人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
发明人： Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Jeffery L. Edelman , Joan-En Chang-Lin , Jane-Guo Shiah , Thierry Nivaggioli
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61K9/1647 , Y10T428/2985
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.
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公开(公告)号：US08318070B2
公开(公告)日：2012-11-27
申请号：US13224041
申请日：2011-09-01
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： B29C47/04
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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公开(公告)号：US20110309546A1
公开(公告)日：2011-12-22
申请号：US13224041
申请日：2011-09-01
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： B29C47/04
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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公开(公告)号：US20080107712A1
公开(公告)日：2008-05-08
申请号：US11931954
申请日：2007-10-31
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US20050048099A1
公开(公告)日：2005-03-03
申请号：US10918597
申请日：2004-08-13
申请人： Jane-Guo Shiah , Rahul Bhagat , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Thierry Nivaggioli , Lin Peng , David Chou , David Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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公开(公告)号：US08506987B2
公开(公告)日：2013-08-13
申请号：US13213473
申请日：2011-08-19
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： A61F2/00 , A61P27/02 , A61P31/04 , A61P29/00 , A61P31/12 , A61P31/10 , A61P3/10 , A61P35/00 , A61K31/56
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US08048445B2
公开(公告)日：2011-11-01
申请号：US12173746
申请日：2008-07-15
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US08034370B2
公开(公告)日：2011-10-11
申请号：US11931954
申请日：2007-10-31
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
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公开(公告)号：US08034366B2
公开(公告)日：2011-10-11
申请号：US11932101
申请日：2007-10-31
申请人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
发明人： Jane-Guo Shiah , Rahul Bhagat , Wendy M. Blanda , Thierry Nivaggioli , Lin Peng , David Chou , David A. Weber
IPC分类号： A61K31/573 , A61F2/14 , A61P27/02
CPC分类号： A61K31/573 , A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1694 , A61K9/204 , A61K31/56
摘要： The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
摘要翻译： 本发明提供了适于植入眼部区域的可生物降解的植入物以及用于治疗眼睛的医学状况的方法。 植入物由亲水末端和疏水末端PLGA的混合物形成，并且将活性剂递送到眼部区域而没有高突释。
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