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14 条记录 (耗时 0.038 秒)

    Method for delivering an agent with biocidal activity in a body fluid receiving container
    3.
    发明授权
    Method for delivering an agent with biocidal activity in a body fluid receiving container 失效
    用于在体液接收容器中递送具有杀生物活性的药剂的方法

    公开(公告)号：US4445889A

    公开(公告)日：1984-05-01

    申请号：US397507

    申请日：1982-07-12

    申请人： Patrick S. Wong ,  Jimmy B. Langston ,  Harold M. Leeper

    发明人： Patrick S. Wong ,  Jimmy B. Langston ,  Harold M. Leeper

    IPC分类号： A61F5/44 ,  A61M1/00 ,  A61M31/00

    CPC分类号： A61F5/44 ,  A61M1/0096

    摘要： A method for preventing an infection in a patient introduced through a indwelling catheter, the method comprising, connecting the patient to the catheter, connecting the catheter to a fluid receiving container, admitting into the container a biocidal dispensing device, and releasing a biocide into fluid in the container for inhibiting the growth of infectious bacteria in the container and concomitantly their introduction into the catheter and the patient.

    摘要翻译： 一种用于防止通过留置导管引入的患者的感染的方法，所述方法包括：将患者连接到导管，将导管连接到流体接收容器，将容器中的杀生物剂分配装置，以及将杀生物剂释放到流体中 在用于抑制容器中的感染性细菌生长的容器中并且伴随地引入到导管和患者体内。

    Elastomeric bladders for medical infusers
    7.
    发明授权
    Elastomeric bladders for medical infusers 失效
    用于医疗输液器的弹性囊

    公开(公告)号：US4938751A

    公开(公告)日：1990-07-03

    申请号：US222448

    申请日：1988-07-21

    申请人： Harold M. Leeper ,  George V. Guittard

    发明人： Harold M. Leeper ,  George V. Guittard

    IPC分类号： A61M5/152 ,  C08L9/00

    CPC分类号： C08L9/00 ,  A61M5/152 ,  Y10S128/12

    摘要： Elastomeric bladders having improved resistance to spontaneous rupture when inflated are made by vulcanizing a homogeneous mixture of synthetic polyisoprene having 90% to 98% cis-1,4 linkages, 3 to 10 phr fumed silicon dioxide, and vulcanizing agent while simultaneously forming the mixture into hollow cylindrical bodies. After being formed the bodies are solvent extracted to remove unreacted vulcanizing agent and the degradation products of the vulcanizing agent. Following the solvent extraction about 0.2 to 2 phr of a nontoxic, nonleachable antioxidant are imbibed into the bodies by contacting the bodies with a liquid solution of the antioxidant.

    摘要翻译： 通过硫化具有90％至98％顺式-1,4键，3至10份热解二氧化硅和硫化剂的合成聚异戊二烯的均匀混合物，同时将该混合物同时形成混合物，制备具有改善的抗膨胀自发破裂的弹性囊 中空圆柱体。 在形成后，将物体进行溶剂萃取以除去未反应的硫化剂和硫化剂的降解产物。 溶剂萃取后，通过使体内与抗氧化剂的液体溶液接触，约0.2至2phr的无毒的不可渗透的抗氧化剂被吸收到体内。

    Elastomeric active agent delivery system and method of use
    8.
    发明授权
    Elastomeric active agent delivery system and method of use 失效
    弹性活性剂递送系统及使用方法

    公开(公告)号：US4435180A

    公开(公告)日：1984-03-06

    申请号：US381994

    申请日：1982-05-25

    申请人： Harold M. Leeper

    发明人： Harold M. Leeper

    IPC分类号： A61K9/70 ,  A61L31/00 ,  A61M35/00 ,  A61K9/00

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61M35/00 ,  Y10S2/901

    摘要： A transdermal therapeutic system is formed from a body member surrounding means at least a portion of which is an active agent loaded elastomer which is in a stretched condition during use. The tension created by the stretching of the elastomer is preferably from 20 to 35 psi and maintains the agent transferring contact between the skin and the transdermal therapeutic system. The transdermal therapeutic system may be in the form of a glove, sock, sleeve, cuff or band, for example.

    摘要翻译： 透皮治疗系统由身体构件形成，围绕装置，其至少一部分是在使用期间处于拉伸状态的活性剂负载的弹性体。 通过弹性体的拉伸产生的张力优选为20至35psi，并且保持试剂在皮肤和透皮治疗系统之间转移接触。 透皮治疗系统可以是例如手套，袜子，袖子，袖口或带的形式。

    Bladder for liquid dispenser
    9.
    发明授权
    Bladder for liquid dispenser 失效
    液体分配器膀胱

    公开(公告)号：US4201207A

    公开(公告)日：1980-05-06

    申请号：US745132

    申请日：1976-11-26

    申请人： Richard G. Buckles ,  Harold M. Leeper

    发明人： Richard G. Buckles ,  Harold M. Leeper

    IPC分类号： A61M5/152 ,  C08L9/00 ,  A61M5/00 ,  B65D35/18 ,  C08C19/00 ,  C08C19/04

    CPC分类号： C08L9/00 ,  A61M5/152 ,  Y10S128/12

    摘要： An improvement in liquid dispensers, especially those used to infuse liquid drugs into patients, that dispense liquid under pressure from an expansible, elastomer bladder is disclosed. The improvement is that the bladder is made from synthetic vulcanized polyisoprene, especially polyisoprene that has 90% to 98% cis linkages and has been vulcanized with an organic peroxide, such as dicumyl peroxide, at a concentration of 5.5.times.10.sup.-3 to 7.5.times.10.sup.-3 moles of peroxide per 100 grams of polyisoprene.

    摘要翻译： 公开了一种液体分配器的改进，特别是那些用于将液体药物注入患者的液体分配器，其在可膨胀的弹性体囊中在压力下分配液体。 改进之处在于，气囊由合成硫化聚异戊二烯制成，特别是具有90％至98％顺式键的聚异戊二烯，并用有机过氧化物如过氧化二异丙苯硫化，浓度为5.5×10-3至7.5×10- 每100克聚异戊二烯3摩尔过氧化物。

    Novel drug permeable wall
    10.
    发明授权
    Novel drug permeable wall 失效
    新型药物可渗透壁

    公开(公告)号：US3938515A

    公开(公告)日：1976-02-17

    申请号：US408233

    申请日：1973-10-19

    申请人： Harold M. Leeper ,  Alan S. Michaels

    发明人： Harold M. Leeper ,  Alan S. Michaels

    IPC分类号： A61F6/14 ,  A61K9/00 ,  A61M31/00 ,  A61F5/46 ,  A61F13/20

    CPC分类号： A61K9/0004 ,  A61F6/142 ,  A61M31/002

    摘要： A polymeric wall adapted to release drug at a controlled rate for a prolonged period of time from a reservoir comprising a drug and a carrier which is permeable to the drug and saturated therewith during said prolonged period of time, to a body environment or a drug receptor site, the wall comprising a mixture of a polymer which is biologically compatible with said environment or site and maintains its integrity while in contact therewith, has a glass transition temperature between ambient temperature and 150.degree.C, a crystallinity of 5% to 95%, or is rubbery, and is permeable to the drug but at a rate less than that of the carrier and as a minor constituent a polymeric additive such as a polyester prepared from a glycol and a dibasic acid, polyethylene glycol, chlorinated polyethylene or copolymers of ethylene and vinyl esters or vinyl esters or vinyl halides, the amount of additive being sufficient to make the permeability of the wall to the drug substantially different than the permeability of the polymer to the drug but still less than the permeability of the carrier to the drug.

    摘要翻译： 适于以受控的速率从包含药物和载体的药剂和载体以可控制的速率释放药物并在所述延长的时间段内饱和的载体的聚合物壁转移至身体环境或药物受体 包括与所述环境或位点生物相容的聚合物的混合物的壁，并且在与其接触的同时保持其完整性的玻璃化转变温度为玻璃化转变温度，环境温度为150℃，结晶度为5％至95％ 或者是橡胶状的，并且对药物是可渗透的，但是其速度比载体低，并且作为次要成分，聚合物添加剂例如由二醇和二元酸制备的聚酯，聚乙二醇，氯化聚乙烯或乙烯的共聚物 和乙烯基酯或乙烯基酯或乙烯基卤化物，添加剂的量足以使得与药物的壁的渗透性基本上不同于烫发 聚合物对药物的有效性，但仍低于载体对药物的渗透性。