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公开(公告)号：US07319097B2
公开(公告)日：2008-01-15
申请号：US11214523
申请日：2005-08-30
申请人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： A61P3/10
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统
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公开(公告)号：US07173035B2
公开(公告)日：2007-02-06
申请号：US10143335
申请日：2002-05-10
申请人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： A61P25/00 , A61K31/497 , A61K31/4965 , C07D401/00 , C07D241/00
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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公开(公告)号：US20060293361A1
公开(公告)日：2006-12-28
申请号：US11447524
申请日：2006-06-05
申请人： Patrizia Caldirola , Gary Johansson , Lori Sutin
发明人： Patrizia Caldirola , Gary Johansson , Lori Sutin
IPC分类号： A61K31/452 , C07D405/02
CPC分类号： C07D405/12
摘要： The present invention relates to compounds of the formula (I), wherein R1 and R2 are as defined in the description; to pharmaceutical formulations comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and/or body weight gain.
摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2如说明书所定义; 涉及包含这些化合物的药物制剂，以及该化合物用于预防和治疗与肥胖症，II型糖尿病和/或CNS疾病有关的医学病症的用途，以实现体重和/或体重增加的减轻。
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公开(公告)号：US20060009446A1
公开(公告)日：2006-01-12
申请号：US11215173
申请日：2005-08-30
申请人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： A61K31/551 , A61K31/495 , C07D241/18
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
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公开(公告)号：US07718650B2
公开(公告)日：2010-05-18
申请号：US11960045
申请日：2007-12-19
申请人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： C07D241/36 , C07D487/02 , A61K31/495 , A61K31/40 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P3/10
CPC分类号： C07D215/36 , C07D243/08 , C07D261/10 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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公开(公告)号：US07582767B2
公开(公告)日：2009-09-01
申请号：US11447524
申请日：2006-06-05
申请人： Patrizia Caldirola , Gary Johansson , Lori Sutin
发明人： Patrizia Caldirola , Gary Johansson , Lori Sutin
IPC分类号： C07D405/02 , A61K31/445
CPC分类号： C07D405/12
摘要： The present invention relates to compounds of the formula (I), wherein R1 and R2 are as defined in the description; to pharmaceutical formulations comprising these compounds, and to the use of the compounds for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes, and/or CNS disorders, to achieve reduction of body weight and/or body weight gain.
摘要翻译： 本发明涉及式（I）化合物，其中R 1和R 2如说明书中所定义; 涉及包含这些化合物的药物制剂，以及该化合物用于预防和治疗与肥胖症，II型糖尿病和/或CNS疾病有关的医学病症的用途，以实现体重和/或体重增加的减轻。
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7.发明授权Substituted sulfonamide compounds useful for the prophylaxis and treatment of conditions relating to obesity, type II diabetes and/or disorders of the central nervous system 失效用于预防和治疗与肥胖，II型糖尿病和/或中枢神经系统疾病有关的病症的取代磺酰胺化合物公开(公告)号：US07566715B2
公开(公告)日：2009-07-28
申请号：US11215173
申请日：2005-08-30
申请人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： C07D241/36 , C07D487/02 , A61K31/495 , A61K31/40 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P3/10
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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公开(公告)号：US20080096873A1
公开(公告)日：2008-04-24
申请号：US11960045
申请日：2007-12-19
申请人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： A61K31/5513 , A61K31/496 , A61P25/00 , C07D241/04 , C07D243/24 , A61P3/04 , A61K31/4965
CPC分类号： C07D215/36 , C07D243/08 , C07D261/10 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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公开(公告)号：US20050288275A1
公开(公告)日：2005-12-29
申请号：US11214523
申请日：2005-08-30
申请人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika Jensen , Gary Johansson , Lori Sutin , Andrew Mott , Jan Tejbrant
IPC分类号： A61K31/42 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/551 , A61P3/04 , A61P3/10 , A61P43/00 , C07D215/36 , C07D233/56 , C07D243/08 , C07D261/10 , C07D295/12 , C07D295/135 , C07D401/12 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08 , A61K31/55
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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公开(公告)号：US06969710B2
公开(公告)日：2005-11-29
申请号：US10144677
申请日：2002-05-13
申请人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Andrew Mott , Lori Sutin , Jan Tejbrant
发明人： Ulf Bremberg , Patrizia Caldirola , Annika J. Jensen , Gary Johansson , Andrew Mott , Lori Sutin , Jan Tejbrant
IPC分类号： A61K31/42 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/551 , A61P3/04 , A61P3/10 , A61P43/00 , C07D215/36 , C07D233/56 , C07D243/08 , C07D261/10 , C07D295/12 , C07D295/135 , C07D401/12 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08 , C07D295/04 , C07D211/46 , C07D241/04
CPC分类号： C07D261/10 , C07D215/36 , C07D243/08 , C07D271/12 , C07D295/135 , C07D401/12 , C07D409/04 , C07D409/14 , C07D413/12 , C07D487/04 , C07D487/08
摘要： The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.
摘要翻译： 本发明涉及通式（I）或式（II）的取代的双芳基磺酰胺和芳基磺酰胺化合物，该化合物潜在地可用于预防和治疗与肥胖，II型糖尿病和/或病症有关的医学病症 的中枢神经系统。
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