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20 条记录 (耗时 0.023 秒)

    New compounds
    3.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号：US20080255153A1

    公开(公告)日：2008-10-16

    申请号：US12079563

    申请日：2008-03-27

    申请人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    发明人： Ulf Bremberg ,  Auri Linden ,  Thomas Lundback ,  Jonas Nilsson ,  Marie Wiik ,  Magnus Bergner ,  Peter Brandt ,  Kristin Hammer ,  Rune Ringom

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P9/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, which are useful as inhibitors of human stearoyl-CoA desaturase (SCD). The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, metabolic syndrome, neurological diseases, immune disorders, cancer and various skin diseases.

    摘要翻译： 本发明涉及可用作人硬脂酰辅酶A去饱和酶（SCD）抑制剂的式（I）化合物及其药学上可接受的盐。 本发明进一步涉及包含这些化合物的药物组合物和这些化合物用于治疗或预防SCD活性调节有益的医学病症的用途，例如心血管疾病，肥胖症，非胰岛素依赖性糖尿病， 高血压，代谢综合征，神经系统疾病，免疫疾病，癌症和各种皮肤疾病。

    Microwave facilitated allyllic substitution
    4.
    发明授权
    Microwave facilitated allyllic substitution 失效
    微波促进了allyllic取代

    公开(公告)号：US06551467B1

    公开(公告)日：2003-04-22

    申请号：US09786199

    申请日：2001-04-16

    申请人： Ulf Bremberg ,  Anders Hallberg ,  Mats Larhed ,  Christina Moberg ,  Nils-Fredrik Kaiser

    发明人： Ulf Bremberg ,  Anders Hallberg ,  Mats Larhed ,  Christina Moberg ,  Nils-Fredrik Kaiser

    IPC分类号： C07F500

    CPC分类号： C07B53/00 ,  C07B37/04 ,  C07C67/343 ,  C07C69/618

    摘要： The present invention is draw to microwave heating of a transition metal-catalysed organic reaction, in which a catalyst complex between a transition metal and an auxiliary ligand or ligands, the ligand being asymmetric or symmetric, monodentate or bidentate, results in highly chemoselective, regioselective, and stereoselective allylic substitution reactions. Molybdenum or palladium complexes form suitable catalytic systems with a plethora of ligands in a variety of solvents for such microwave facilitated nucleophilic substitution reactions.

    摘要翻译： 本发明涉及过渡金属催化的有机反应的微波加热，其中过渡金属和辅助配体或配体之间的催化剂络合物，不对称或对称的单齿或双齿配体导致高度化学选择性的区域选择性 ，和立体选择性烯丙基取代反应。 钼或钯络合物形成合适的催化体系，在各种溶剂中具有多种配体，用于这种微波促进的亲核取代反应。

    New compounds
    9.
    发明申请
    New compounds 审中-公开
    新化合物

    公开(公告)号：US20080221129A1

    公开(公告)日：2008-09-11

    申请号：US11825431

    申请日：2007-07-06

    申请人： Thomas Lundback ,  Isabel Climent-Johansson ,  Jan Vagberg ,  Auri Linden ,  Jonas Nilsson ,  Marie Wiik ,  Ulf Bremberg

    发明人： Thomas Lundback ,  Isabel Climent-Johansson ,  Jan Vagberg ,  Auri Linden ,  Jonas Nilsson ,  Marie Wiik ,  Ulf Bremberg

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P9/00 ,  A61P3/04 ,  A61P25/00 ,  A61P17/00

    CPC分类号： C07D487/04

    摘要： The present invention relates to compounds of the formula (I): including pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers, and N-oxides thereof, said compounds being useful as inhibitors of stearoyl-CoA desaturase (SCD). The invention further relates to the use of compounds of the formula (I) for treatment of medical conditions in which the modulation of SCD activity is beneficial, such as cardiovascular diseases, obesity, non-insulin-dependent diabetes mellitus, hypertension, neurological diseases, immune disorders, cancer, essential fatty acid deficiency, acne, psoriasis, rosacea or other skin conditions.

    摘要翻译： 本发明涉及式（I）化合物：其药学上可接受的盐，溶剂化物，水合物，几何异构体，互变异构体，旋光异构体及其N-氧化物，所述化合物可用作硬脂酰辅酶A去饱和酶（SCD） 。 本发明还涉及式（I）化合物用于治疗其中SCD活性调节有益的医学病症，例如心血管疾病，肥胖症，非胰岛素依赖性糖尿病，高血压，神经系统疾病， 免疫疾病，癌症，必需脂肪酸缺乏症，痤疮，牛皮癣，酒渣鼻或其他皮肤病症。