公开(公告)号：US06605617B2

公开(公告)日：2003-08-12

申请号：US09951265

申请日：2001-09-11

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

IPC分类号： C07D47104

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

摘要翻译： 提供具有式I和II的有机化合物，其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。

公开(公告)号：US06774237B2

公开(公告)日：2004-08-10

申请号：US10284017

申请日：2002-10-30

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

IPC分类号： C07D21516

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

摘要翻译： 提供具有式I和II的有机化合物，其中变量具有本文所述的值。药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物或其药学上可接受的盐 有机化合物与载体和水。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。

公开(公告)号：US07598268B2

公开(公告)日：2009-10-06

申请号：US10886950

申请日：2004-07-08

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea ,  Christopher McBride ,  Elisa Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea ,  Christopher McBride ,  Elisa Jazan

IPC分类号： A61K31/44

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

摘要翻译： 提供具有式I的有机化合物，其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。

公开(公告)号：US07335774B2

公开(公告)日：2008-02-26

申请号：US11092137

申请日：2005-03-29

申请人： Paul A. Renhowe ,  Cynthia M. Shafer ,  Timothy D. Machajewski ,  Sabina Pecchi ,  Christopher McBride

发明人： Paul A. Renhowe ,  Cynthia M. Shafer ,  Timothy D. Machajewski ,  Sabina Pecchi ,  Christopher McBride

IPC分类号： C07D215/38

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.

摘要翻译： 合成4-氨基取代的喹啉酮的方法包括在碱或酸的存在下使取代或未取代的2-苯并咪唑-2-乙酸酯与取代或未取代的2-氨基苄腈反应。 通过反应形成4-氨基取代的喹啉酮化合物，4-氨基取代的喹啉酮化合物包括苯并咪唑基。

公开(公告)号：US20090281100A1

公开(公告)日：2009-11-12

申请号：US12317493

申请日：2008-12-23

申请人： Paul A. Barsanti ,  Dirksen Bussiere ,  Stephen D. Harrison ,  Carla C. Heise ,  Johanna M. Jansen ,  Elisa Jazan ,  Timothy D. Machajewski ,  Christopher McBride ,  William R. McCrea, JR. ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Savithri Ramurthy ,  Paul A. Renhowe ,  Cynthia M. Shafer ,  Joel B. Silver ,  Allan S. Wagman ,  Marion Wiesmann ,  Kelly Wayman

发明人： Paul A. Barsanti ,  Dirksen Bussiere ,  Stephen D. Harrison ,  Carla C. Heise ,  Johanna M. Jansen ,  Elisa Jazan ,  Timothy D. Machajewski ,  Christopher McBride ,  William R. McCrea, JR. ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Savithri Ramurthy ,  Paul A. Renhowe ,  Cynthia M. Shafer ,  Joel B. Silver ,  Allan S. Wagman ,  Marion Wiesmann ,  Kelly Wayman

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/4709

CPC分类号： C07D401/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/52 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/04

摘要： Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.

摘要翻译： 提供了抑制各种酶和治疗各种病症的方法，其包括向受试者施用结构I或IB的化合物，其药学上可接受的盐，其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物，并用于治疗由这些酶介导的病症。

公开(公告)号：US07470709B2

公开(公告)日：2008-12-30

申请号：US10644055

申请日：2003-08-19

申请人： Paul A. Barsanti ,  Dirksen Bussiere ,  Stephen D. Harrison ,  Carla C. Heise ,  Johanna M. Jansen ,  Elisa Jazan ,  Timothy D. Machajewski ,  Christopher McBride ,  William R. McCrea, Jr. ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Savithri Ramurthy ,  Paul A. Renhowe ,  Cynthia M. Shafer ,  Joel B. Silver ,  Allan S. Wagman ,  Marion Wiesmann ,  Kelly Wayman

发明人： Paul A. Barsanti ,  Dirksen Bussiere ,  Stephen D. Harrison ,  Carla C. Heise ,  Johanna M. Jansen ,  Elisa Jazan ,  Timothy D. Machajewski ,  Christopher McBride ,  William R. McCrea, Jr. ,  Simon Ng ,  Zhi-Jie Ni ,  Sabina Pecchi ,  Keith B. Pfister ,  Savithri Ramurthy ,  Paul A. Renhowe ,  Cynthia M. Shafer ,  Joel B. Silver ,  Allan S. Wagman ,  Marion Wiesmann ,  Kelly Wayman

IPC分类号： A61K31/47

CPC分类号： C07D401/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/52 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/04

摘要： Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.

摘要翻译： 提供了抑制各种酶和治疗各种病症的方法，其包括向受试者施用结构I或IB的化合物，其药学上可接受的盐，其互变异构体或互变异构体的药学上可接受的盐。 具有结构I和IB的化合物具有以下结构并具有本文所述的变量。 这些化合物可用于制备用于抑制各种酶的药物，并用于治疗由这些酶介导的病症。

公开(公告)号：US20100184754A1

公开(公告)日：2010-07-22

申请号：US12651612

申请日：2010-01-04

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, JR. ,  Christopher McBride ,  Elisa Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, JR. ,  Christopher McBride ,  Elisa Jazan

IPC分类号： A61K31/541 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/5377 ,  A61P35/04

CPC分类号： C07D471/04 ,  A61K31/19 ,  A61K31/439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  A61K2300/00

摘要： Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

摘要翻译： 提供具有式I和II的有机化合物，其中变量具有本文所述的值。 药物制剂包括有机化合物或其药学上可接受的盐和药学上可接受的载体，并且可以通过将有机化合物的有机化合物或药学上可接受的盐与载体和水混合来制备。 治疗患者的方法包括向有需要的患者施用本发明的药物制剂。

公开(公告)号：US07064215B2

公开(公告)日：2006-06-20

申请号：US10187967

申请日：2002-07-02

申请人： Paul A. Renhowe ,  Cynthia M. Shafer ,  Christopher McBride ,  Joel Benjamin Silver ,  Sabina Pecchi ,  Timothy D. Machajewski ,  William R. McCrea, Jr. ,  Daniel J. Poon ,  Teresa Thomas

发明人： Paul A. Renhowe ,  Cynthia M. Shafer ,  Christopher McBride ,  Joel Benjamin Silver ,  Sabina Pecchi ,  Timothy D. Machajewski ,  William R. McCrea, Jr. ,  Daniel J. Poon ,  Teresa Thomas

IPC分类号： C07D271/02 ,  C07D285/14

CPC分类号： C07D403/04

摘要： Organic compounds having the structure I are provided where the variables have the values described herein. Pharmaceutical formulations and medicaments include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compound or a pharmaceutically acceptable salt of the organic compound with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation or medicament according to the invention to a patient in need thereof.

公开(公告)号：US06800760B2

公开(公告)日：2004-10-05

申请号：US10613411

申请日：2003-07-03

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Elisa Jazan

IPC分类号： C07D21516

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.

公开(公告)号：US06762194B2

公开(公告)日：2004-07-13

申请号：US10387355

申请日：2003-03-12

申请人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Eliza Jazan

发明人： Paul A. Renhowe ,  Sabina Pecchi ,  Timothy D. Machajewski ,  Cynthia M. Shafer ,  Clarke Taylor ,  William R. McCrea, Jr. ,  Christopher McBride ,  Eliza Jazan

IPC分类号： A61K3147

CPC分类号： C07D409/04 ,  A61K31/19 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/513 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  A61K2300/00

摘要： Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.