公开(公告)号：US07633616B2

公开(公告)日：2009-12-15

申请号：US10559140

申请日：2003-06-02

申请人： Paul Anthony Hing

发明人： Paul Anthony Hing

IPC分类号： G01J3/26

CPC分类号： G01J3/2803 ,  G01N21/31

摘要： An apparatus and a method for photo-electric measurement is included; the apparatus comprises photo-electric conversion devices and an optical system which is modularly expandable in order to acquire electromagnetic radiation from a line or area of any desired size on an object. The optical system preferably separates the electromagnetic radiation modularly into a plurality of smaller segments and projects electromagnetic radiation corresponding to the smaller segments onto individual photo-electric conversion devices and sensor electronics related to said photo-electric conversion device(s). This enables the operating mode and functionality of said photo-electric conversion device(s) to be defined and changed in real-time, whereby functions such as the readout sequence of pixels and unlimited flexibility of pixel binning in two dimensions are fully programmable, and the photo-electric conversion device(s) can operate and/or be controlled independently and/or simultaneously.

摘要翻译： 包括光电测量的装置和方法; 该装置包括光电转换装置和模块化可扩展的光学系统，以便从物体上的任何所需尺寸的线或区域获取电磁辐射。 光学系统优选地将电磁辐射模块化地分离成多个较小的部分，并将对应于较小的部分的电磁辐射投射到与所述光电转换装置相关的各个光电转换装置和传感器电子装置上。 这使得能够实时地定义和改变所述光电转换装置的操作模式和功能，由此像素的读出序列和二维像素合并的无限灵活性的功能是完全可编程的，并且 光电转换装置可以独立地和/或同时地操作和/或控制。

公开(公告)号：US20110090332A1

公开(公告)日：2011-04-21

申请号：US12927602

申请日：2010-11-18

申请人： Paul Anthony Hing

发明人： Paul Anthony Hing

IPC分类号： H04N7/18

CPC分类号： G01J3/02 ,  G01J3/0286 ,  G01J3/2803 ,  H04N5/341 ,  H04N5/374 ,  H04N5/3765

摘要： The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and volumes are in the sub-nanoliter range). Such “intelligent sensing” allows higher data quality and reliability, higher measurement and analysis throughput and lower cost.The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed. Through real-time adaptive control of sensors, chemical/opto-mechanical/opto-electronic processes and other components during the measurement process, consistently higher quality results and higher reliability are achieved. This invention furthermore includes an improved image sensor architecture that enables very high intra-array dynamic range at fast frame rates and low noise performance.

摘要翻译： 本发明涉及一种用于实时闭环控制的光学测量和检测的装置和方法，其实现更高水平的性能。 本发明特别适用于光谱学; 显微镜; 生化测定; 微型化格式的过程和反应（如涉及微/纳米板，微格式和微阵列，片上化学，片上实验室，微通道和微流体学的方法和反应，其尺寸在 微米级和体积在亚纳升范围内）。 这种“智能感知”可以提供更高的数据质量和可靠性，更高的测量和分析吞吐量，并降低成本。 本发明使用快速实时自适应数字信号处理和直接在数据被感测的位置进行控制。 通过在测量过程中通过传感器，化学/光机电/光电子工艺和其他部件的实时自适应控制，实现了更高质量的结果和更高的可靠性。 本发明还包括改进的图像传感器架构，其能够以快速帧速率和低噪声性能实现非常高的阵列内动态范围。

公开(公告)号：US07839450B2

公开(公告)日：2010-11-23

申请号：US10380570

申请日：2001-09-24

申请人： Paul Anthony Hing

发明人： Paul Anthony Hing

IPC分类号： G05B15/00 ,  G05B19/00 ,  H04N5/235 ,  H04N5/225 ,  G03B7/00

CPC分类号： G01J3/02 ,  G01J3/0286 ,  G01J3/2803 ,  H04N5/341 ,  H04N5/374 ,  H04N5/3765

摘要： The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and columns are in the sub-nanoliter range). Such “intelligent sensing” allows higher data quality and reliability, higher measurement and analysis throughput and lower cost. The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed. Through real-time adaptive control of sensors, chemical/opto-mechanical/opto-electronic processes and other components during the measurement process, consistently higher quality results and higher reliability are achieved. This invention furthermore includes an improved image sensor architecture that enables very intra-array dynamic range at fast frame rates and low noise performance.

摘要翻译： 本发明涉及一种用于实时闭环控制的光学测量和检测的装置和方法，其实现更高水平的性能。 本发明特别适用于光谱学; 显微镜; 生化测定; 微型化格式的过程和反应（如涉及微/纳米板，微格式和微阵列，片上化学，片上实验室，微通道和微流体学的方法和反应，其尺寸在 微米级和色谱柱处于亚纳升范围内）。 这种“智能感知”可以提供更高的数据质量和可靠性，更高的测量和分析吞吐量，并降低成本。 本发明使用快速实时自适应数字信号处理和直接在数据被感测的位置进行控制。 通过在测量过程中通过传感器，化学/光机电/光电子工艺和其他部件的实时自适应控制，实现了更高质量的结果和更高的可靠性。 本发明还包括改进的图像传感器架构，其能够以快速帧速率和低噪声性能实现非常阵列内的动态范围。