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    Caspase Activated Prodrugs Therapy
    1.
    发明申请
    Caspase Activated Prodrugs Therapy 审中-公开
    胱天蛋白酶活化前药治疗

    公开(公告)号：US20070104719A1

    公开(公告)日：2007-05-10

    申请号：US11537578

    申请日：2006-09-29

    申请人： Paul Carter ,  Lewis Gazzard

    发明人： Paul Carter ,  Lewis Gazzard

    IPC分类号： A61K39/395

    CPC分类号： C07K16/32 ,  A61K47/6899 ,  B82Y5/00 ,  C07K2317/24 ,  C07K2317/55

    摘要： The invention provides novel method for the localized delivery of pharmaceutical agents by the administration of a caspase conjugate that targets a cell type of interest and the additional administration of a pro-agent that is locally converted, in the presence of the caspase, to an active agent. The invention further provides novel tageting agents comprising a caspase as well as novel prodrugs comprising a caspase cleavable prodrug moiety. The invention also provides pharmaceutical compositions as well as methods of treatment comprising the caspase conjugates and prodrugs of the invention

    摘要翻译： 本发明提供了通过施用靶向感兴趣的细胞类型的半胱天冬酶缀合物来局部递送药物的新方法，并且在半胱天冬酶的存在下局部转化的前药的另外施用为活性 代理商 本发明进一步提供了包含胱天蛋白酶的新型标签试剂以及包含半胱天冬酶可切割前药部分的新型前体药物。 本发明还提供药物组合物以及包含本发明的半胱天冬酶缀合物和前药的治疗方法

    MEDICAL DEVICE AND PROSTHESIS
    2.
    发明申请
    MEDICAL DEVICE AND PROSTHESIS 审中-公开

    公开(公告)号：US20180178011A1

    公开(公告)日：2018-06-28

    申请号：US15816256

    申请日：2017-11-17

    申请人： Paul Carter

    发明人： Paul Carter

    IPC分类号： A61N1/36 ,  A61F2/18 ,  A61N1/05 ,  A61N1/02 ,  A61N1/372 ,  H04R25/00

    CPC分类号： A61N1/36038 ,  A61B5/053 ,  A61B5/7264 ,  A61F2/18 ,  A61F2002/183 ,  A61N1/025 ,  A61N1/0541 ,  A61N1/36036 ,  A61N1/37229 ,  H04R25/505 ,  H04R25/604 ,  H04R2225/67

    摘要： A hearing prosthesis, comprising: a microphone; a sound processor; an external transmitter unit including a coil; an internal receiver unit including a coil; a stimulator unit, wherein the stimulator unit includes a control circuit, a voltage measurement component, a resistor and a signal generator, wherein the measurement circuit is configured to output a signal indicative of the voltage across the resistor; and a stimulating lead assembly array, wherein at least a portion of the hearing prosthesis is configured to apply an electrical signal to tissue inside a cochlea of a recipient, and at least a portion of the hearing prosthesis is configured to sense an electrical property inside of the cochlea that results from the applied electrical signal and the interaction of the applied electrical signal to the tissue.

    Variable impedance shunt for a tissue stimulating prosthesis
    5.
    发明授权
    Variable impedance shunt for a tissue stimulating prosthesis 有权
    用于组织刺激假体的可变阻抗分流器

    公开(公告)号：US08843208B2

    公开(公告)日：2014-09-23

    申请号：US13675229

    申请日：2012-11-13

    申请人： Paul Carter

    发明人： Paul Carter

    IPC分类号： A61N1/00 ,  A61N1/08 ,  H03K17/51 ,  A61N1/05 ,  A61N1/36

    CPC分类号： A61N1/0541 ,  A61N1/08 ,  A61N1/36036 ,  A61N1/3605 ,  H03K17/51

    摘要： A method and apparatus for neural stimulation are disclosed. The principle is that a conventional current path is used to deliver the stimulus to neural structures, but an alternative current path is provided to bypass the neural structures during the opposite polarity part of the current flow. As a consequence, charge balance can be provided at the tissue/electrode interface, whilst delivering stimuli which are not charge balanced to the neural structures.

    摘要翻译： 公开了一种用于神经刺激的方法和装置。 原理是使用传统的电流路径将刺激传递给神经结构，但提供替代的电流路径以在电流的相反极性部分旁路神经结构。 因此，可以在组织/电极界面处提供电荷平衡，同时递送对神经结构不是电荷平衡的刺激。

    ROTARY SPUTTERING TARGET AND APPARATUS FOR MANUFACTURE
    8.
    发明申请
    ROTARY SPUTTERING TARGET AND APPARATUS FOR MANUFACTURE 审中-公开
    旋转飞溅目标和制造装置

    公开(公告)号：US20110168555A1

    公开(公告)日：2011-07-14

    申请号：US13052484

    申请日：2011-03-21

    申请人： Al Nolette ,  Paul Carter ,  Dean Plaisted ,  Alan Plaisted

    发明人： Al Nolette ,  Paul Carter ,  Dean Plaisted ,  Alan Plaisted

    IPC分类号： C23C14/34

    CPC分类号： C23C14/3407 ,  H01J37/34 ,  H01J37/342 ,  H01J37/3491

    摘要： The process that is the subject of this invention is a method of making a rotary sputtering target having the steps of providing a cylinder of sputtering target material having an adhesion-wetting layer on its inside surface; providing a stainless steel sputtering target backing tube having an outside diameter smaller than the sputtering target material inside diameter, the backing tube having an adhesion-wetting layer on its outside surface; welding an upper and lower stainless steel retaining ring to the backing tube adjacent to the sputtering target material so that the target material is in compression and the backing tube in tension; and introducing molten bonding material into the annulus between the backing tube and the sputtering target material.The apparatus that is the subject of the present invention is a rotary sputtering target apparatus having a cylinder of sputtering target material; a backing tube having a smaller outside diameter than the inside diameter of the sputtering target material; and bonding material disposed between the target material and backing tube, the bonding material bonding them together.

    摘要翻译： 作为本发明的主题的方法是制造旋转溅射靶的方法，其具有以下步骤：在其内表面上设置具有粘附润湿层的溅射靶材料的圆筒; 提供具有小于溅射靶材料内径的外径的不锈钢溅射靶背衬管，所述背衬管在其外表面上具有粘附润湿层; 将上下不锈钢保持环焊接到与溅射靶材料相邻的背衬管上，使得目标材料处于压缩状态并使背衬管张紧; 并将熔融粘合材料引入到背衬管和溅射靶材料之间的环形空间中。 作为本发明的主题的装置是具有溅射靶材料的圆筒的旋转溅射靶装置， 具有比溅射靶材料的内径小的外径的背衬管; 以及设置在目标材料和背衬管之间的接合材料，所述粘合材料将它们结合在一起。