摘要:
A scalpel of the present invention includes an elongate handle defining a longitudinal axis and having a proximal end and a distal end. The scalpel of the invention further includes a cartridge that is removably mounted to the handle. The cartridge has blade holder with a proximal end and a distal end with a blade fixedly attached that is disposed so that the blade projects distally outwardly when the cartridge is mounted to the handle. The cartridge also includes a shield that is slidably mounted onto the blade holder for movement between a distal position where the shield substantially prevents inadvertent access to the blade and a proximal position where the shield substantially surrounds a portion of the handle and the blade is exposed for use. The cartridge is releasably mountable on the handle. The shield is substantially prevented from movement to the proximal position unless the cartridge is mounted on the handle and not dismountable from the handle unless the shield is in the distal position.
摘要:
The present invention relates to protein complexes or scaffold comprising cartilage oligomeric matrix protein (COMP) polypeptides bound to one or more growth factors, and methods of their use in promoting chondrogenesis and/or osteogenesis, and repair of cartilage and bone lesions.
摘要:
An applicator for applying a strap around a vein at the site of a defective venous valve includes a handle portion and a removable cartridge. One end of the strap is anchored on the anvil of the cartridge and the free end is looped around the vein and passed through an opening in the cartridge to overlie the anchored end. The free end of the strap is connected to a strap puller within the cartridge which is coupled to a strap puller extension within the handle when the cartridge is inserted in the handle. The perimeter of the loop is adjusted by moving the tensioner on the handle. When the loop perimeter is at its desired value, the triggers on the handle are pressed to drive a staple through the overlying portion of the strap. A knife within the cartridge cuts the excess strap from the loop.