公开(公告)号：US20090005682A1

公开(公告)日：2009-01-01

申请号：US11824388

申请日：2007-06-28

申请人： Liexiang Fan ,  Paul Freiburger

发明人： Liexiang Fan ,  Paul Freiburger

IPC分类号： A61B8/08 ,  G06F19/00

CPC分类号： A61B8/08 ,  A61B8/485

摘要： Complex response of tissue is calculated as function of a convolution relationship associated with measured strain with applied stress. In the Fourier or frequency domain, the convolution is a simple algebraic computation, such as multiplication. The complex response provides elasticity and viscosity information, assisting diagnosis. Complex compliance may be directly calculated from the strain and stress. Complex fluidity may be directly calculated from strain rate and stress.

摘要翻译： 计算组织的复杂响应作为与所施加的应力的测量应变相关联的卷积关系的函数。 在傅立叶或频域中，卷积是一个简单的代数计算，如乘法。 复杂的反应提供弹性和粘度信息，辅助诊断。 复杂的顺应性可以从应变和应力直接计算。 复杂流动性可以从应变率和应力直接计算。

公开(公告)号：US20100016718A1

公开(公告)日：2010-01-21

申请号：US12174011

申请日：2008-07-16

申请人： Liexiang Fan ,  Paul Freiburger ,  Richard Chiao ,  Greg Sherwin ,  Thomas Edward Cezeaux

发明人： Liexiang Fan ,  Paul Freiburger ,  Richard Chiao ,  Greg Sherwin ,  Thomas Edward Cezeaux

IPC分类号： A61B8/00

CPC分类号： A61B8/00 ,  A61B8/463 ,  A61B8/485 ,  G01S7/52042

摘要： Shear wave imaging is provided in medical diagnostic ultrasound. A region is imaged to determine a location in which to calculate shear velocity. The shear velocity is estimated for the location. The imaging may guide the identification of the location, reducing the time to determine useful shear information. The estimate of shear may be validated, such as using cross-validation, to indicate the confidence level of the shear value. The shear velocity may be displayed relative to a scale of shear velocities associated with a type of tissue, such as tissue for an organ. The location on a scale may be more intuitive for a user.

摘要翻译： 医学诊断超声波提供剪切波成像。 成像一个区域以确定计算剪切速度的位置。 估计剪切速度的位置。 成像可以指导位置的识别，减少确定有用剪切信息的时间。 可以验证剪切的估计，例如使用交叉验证来指示剪切值的置信水平。 剪切速度可以相对于与一种类型的组织（例如器官的组织）相关联的剪切速度的尺度显示。 比例尺上的位置对用户来说可能更直观。

公开(公告)号：US20070043293A1

公开(公告)日：2007-02-22

申请号：US11590569

申请日：2006-10-30

申请人： Paul Jones ,  Paul Freiburger ,  Craig Robinson ,  Stephen Czenszak ,  Christian Deforge

发明人： Paul Jones ,  Paul Freiburger ,  Craig Robinson ,  Stephen Czenszak ,  Christian Deforge

IPC分类号： A61B8/00

CPC分类号： A61B8/4254 ,  A61B8/00 ,  A61B8/483

摘要： Methods and systems for measuring transducer movement are provided. For example, free-hand scanning for three-dimensional imaging is provided. An optical sensor within the transducer measures motion along the skin surface similar to measuring movement of a personal computer mouse with an optical sensor. Alternatively or additionally, the transducer is tilted at an angle other than perpendicular to the skin surface generally towards or away from the direction in which the transducer is translated. The transducer is then translated while maintaining the angle. Motion to or from the transducer is measured, and a component of the motion measured while the transducer is maintained at an angle is parallel to the direction of translation. The component of motion is angle corrected and used to determine a distance of travel.

摘要翻译： 提供了测量传感器运动的方法和系统。 例如，提供用于三维成像的自由扫描。 换能器内的光学传感器测量皮肤表面的运动，类似于使用光学传感器测量个人计算机鼠标的移动。 或者或另外，换能器以与换能器平移方向大致相反或远离换能器方向的角度倾斜，而不是垂直于皮肤表面。 然后在保持角度的同时平移换能器。 测量与传感器的运动，并且在换能器保持一定角度时测量的运动的分量平行于平移方向。 运动的分量被角度校正，用于确定行驶距离。

公开(公告)号：US10338203B2

公开(公告)日：2019-07-02

申请号：US13229408

申请日：2011-09-09

申请人： Liexiang Fan ,  Paul Freiburger ,  John Benson

发明人： Liexiang Fan ,  Paul Freiburger ,  John Benson

IPC分类号： G01S7/52 ,  A61B8/08 ,  A61B8/14 ,  G03B42/06

摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.

公开(公告)号：US10004474B2

公开(公告)日：2018-06-26

申请号：US12913599

申请日：2010-10-27

申请人： Paul Freiburger ,  Liexiang Fan ,  Roee Lazebnik

发明人： Paul Freiburger ,  Liexiang Fan ,  Roee Lazebnik

IPC分类号： A61B8/08 ,  G01S7/52

CPC分类号： A61B8/0825 ,  A61B8/485 ,  A61B8/5223 ,  G01S7/52042 ,  G06T7/0012 ,  G06T7/10

摘要： Tissue density is quantified using shear wave information in medical ultrasound scanning. Measurements of the tissue reaction to shear waves indicate tissue density. For example, shear wave velocity is linked with density using clinical study information. The shear wave velocity in a region, over the entire tissue, or at various locations is used to determine a corresponding density or densities. The tissue density information is used for categorization, estimation of disease risk, imaging, diagnosis, or other uses. The tissue may be breast tissue or other tissue.

公开(公告)号：US20130066204A1

公开(公告)日：2013-03-14

申请号：US13229408

申请日：2011-09-09

申请人： Liexiang Fan ,  Paul Freiburger ,  John Benson

发明人： Liexiang Fan ,  Paul Freiburger ,  John Benson

IPC分类号： A61B8/00

CPC分类号： G01S7/52036 ,  A61B8/0858 ,  A61B8/14 ,  A61B8/485 ,  A61B8/5207 ,  A61B8/5223 ,  G01S7/52022 ,  G03B42/06

摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.

摘要翻译： 为医学超声剪切波成像提供分类预处理。 响应于应力，测量患者中一个或多个位置处的位移。 时间上的位移是表示位置偏移的曲线。 使用曲线的一个或多个特征，例如信噪比和最大位移，用于对位置进行分类。 该位置被分类为流体或流体组织，固体组织或非决定性的。 随后的剪切成像可以为固体组织的位置提供剪切信息，而不是在其他位置。

公开(公告)号：US20120215110A1

公开(公告)日：2012-08-23

申请号：US13032834

申请日：2011-02-23

申请人： Wilko Wilkening ,  Saurabh Datta ,  Paul Freiburger ,  Chi-Yin Lee

发明人： Wilko Wilkening ,  Saurabh Datta ,  Paul Freiburger ,  Chi-Yin Lee

IPC分类号： A61B8/00

CPC分类号： A61B8/488 ,  A61B8/06 ,  A61B8/463 ,  A61B8/486 ,  A61B8/5223 ,  A61B8/5246 ,  G01S7/52066 ,  G01S7/52088 ,  G01S7/5209 ,  G01S7/52092 ,  G01S7/52093 ,  G01S7/52095

摘要： Spatially distinct Spectral Doppler information is acquired. Spatially distinct transmit beams are formed at a same time or in parallel. One or more receive beams are formed in response to each transmit beam, providing samples for a plurality of laterally spaced locations. A spectrum is determined for each of a plurality of spatial locations. In another approach, samples are acquired for different regions at different times. The scanning for each region is interleaved based on the anatomic operation. Since spectral estimation relies on a time-continuous series of transmission and reception, the scanning for a region occurs over a sufficient period for spectral estimation before the scanning for a different region occurs. By using anatomic operation, sufficient time is provided for spectral estimation. Due to anatomic operation, different regions are associated with flow at different times.

摘要翻译： 获取空间不同的光谱多普勒信息。 空间不同的发射光束同时或并行地形成。 响应于每个发射束形成一个或多个接收波束，为多个横向间隔的位置提供采样。 为多个空间位置中的每一个确定频谱。 在另一种方法中，在不同时间针对不同区域采集样本。 基于解剖操作对每个区域进行扫描。 由于频谱估计依赖于时间连续的发射和接收序列，所以在针对不同区域的扫描发生之前，区域的扫描发生在足够的时间段用于谱估计。 通过使用解剖操作，为光谱估计提供足够的时间。 由于解剖操作，不同的区域与不同时间的流量有关。

公开(公告)号：US20080027322A1

公开(公告)日：2008-01-31

申请号：US11904646

申请日：2007-09-28

申请人： Paul Freiburger

发明人： Paul Freiburger

IPC分类号： A61B8/00

CPC分类号： A61B8/06 ,  A61B8/13 ,  A61B8/4405 ,  A61B8/4411 ,  A61B8/4483 ,  A61B8/467 ,  G01S7/5208 ,  G01S15/8925 ,  G01S15/8927 ,  G01S15/8984

摘要： Methods and systems for acquiring spectral and velocity information with a multi-dimensional array are provided. For example, a dedicated receive aperture is formed at a multi-dimensional array for steered continuous wave imaging. Other elements not within the dedicated receive aperture are used for transmitting continuous waves or transmitting and receiving pulsed waveforms in other modes of imaging. As another example, switches or other structures are provided for selecting between a plurality of possible apertures for a steered continuous wave aperture. The selection is performed in response to a configuration of an ultrasound system, such as selection of a focal location or steer direction. The aperture is then used for either transmit or receive operations of steered continuous wave imaging. As yet another example, at least part of the steered continuous wave beamformer is provided within a transducer assembly. The transducer assembly includes a probe housing and a connector housing electrically connected by a cable. In yet another example, at least one angle of a three-dimensional indication of flow direction is input from a user. Velocity values in either steered continuous wave imaging or pulsed wave imaging are corrected as a function of a three-dimensional indication of flow direction.

摘要翻译： 提供了采用多维阵列获取光谱和速度信息的方法和系统。 例如，用于转向连续波成像的多维阵列形成专用接收孔径。 不在专用接收孔径内的其他元件用于传输连续波或在其他成像模式中发送和接收脉冲波形。 作为另一示例，提供开关或其他结构用于在用于转向连续波孔的多个可能的孔之间进行选择。 响应于超声系统的配置，例如选择焦点位置或转向方向来执行选择。 然后，孔径用于传导或接收转向连续波成像的操作。 作为另一示例，至少部分转向连续波束形成器设置在换能器组件内。 换能器组件包括探针壳体和通过电缆电连接的连接器壳体。 在又一示例中，从用户输入流动方向的三维指示的至少一个角度。 转向连续波成像或脉冲波成像中的速度值作为流动方向的三维指示的函数被校正。

公开(公告)号：US08187187B2

公开(公告)日：2012-05-29

申请号：US12174011

申请日：2008-07-16

申请人： Liexiang Fan ,  Paul Freiburger ,  Richard Chiao ,  Greg Sherwin ,  Thomas Edward Cezeaux

发明人： Liexiang Fan ,  Paul Freiburger ,  Richard Chiao ,  Greg Sherwin ,  Thomas Edward Cezeaux

IPC分类号： A61B8/00

CPC分类号： A61B8/00 ,  A61B8/463 ,  A61B8/485 ,  G01S7/52042

摘要： Shear wave imaging is provided in medical diagnostic ultrasound. A region is imaged to determine a location in which to calculate shear velocity. The shear velocity is estimated for the location. The imaging may guide the identification of the location, reducing the time to determine useful shear information. The estimate of shear may be validated, such as using cross-validation, to indicate the confidence level of the shear value. The shear velocity may be displayed relative to a scale of shear velocities associated with a type of tissue, such as tissue for an organ. The location on a scale may be more intuitive for a user.

摘要翻译： 医学诊断超声波提供剪切波成像。 成像一个区域以确定计算剪切速度的位置。 估计剪切速度的位置。 成像可以指导位置的识别，减少确定有用剪切信息的时间。 可以验证剪切的估计，例如使用交叉验证来指示剪切值的置信水平。 剪切速度可以相对于与一种类型的组织（例如器官的组织）相关联的剪切速度的尺度显示。 比例尺上的位置对用户来说可能更直观。

公开(公告)号：US20120108968A1

公开(公告)日：2012-05-03

申请号：US12913599

申请日：2010-10-27

申请人： Paul Freiburger ,  Liexiang Fan ,  Roee Lazebnik

发明人： Paul Freiburger ,  Liexiang Fan ,  Roee Lazebnik

IPC分类号： A61B8/00

CPC分类号： A61B8/0825 ,  A61B8/485 ,  A61B8/5223 ,  G01S7/52042

摘要： Tissue density is quantified using shear wave information in medical ultrasound scanning. Measurements of the tissue reaction to shear waves indicate tissue density. For example, shear wave velocity is linked with density using clinical study information. The shear wave velocity in a region, over the entire tissue, or at various locations is used to determine a corresponding density or densities. The tissue density information is used for categorization, estimation of disease risk, imaging, diagnosis, or other uses. The tissue may be breast tissue or other tissue.

摘要翻译： 在医学超声扫描中使用剪切波信息量化组织密度。 对剪切波的组织反应的测量表明组织密度。 例如，使用临床研究信息，剪切波速度与密度相关。 使用在整个组织或各个位置的区域中的剪切波速度来确定相应的密度或密度。 组织密度信息用于分类，估计疾病风险，成像，诊断或其他用途。 组织可以是乳房组织或其他组织。