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24 条记录 (耗时 0.044 秒)

    Imidazolidine carboxamide derivatives as P2X7 modulators
    8.
    发明授权
    Imidazolidine carboxamide derivatives as P2X7 modulators 失效
    咪唑烷羧酰胺衍生物作为P2X7调节剂

    公开(公告)号：US07932282B2

    公开(公告)日：2011-04-26

    申请号：US12594381

    申请日：2008-04-02

    申请人： Paul John Beswick ,  David Kenneth Dean ,  Robert James Gleave ,  Andrew Peter Moses ,  Daryl Simon Walter

    发明人： Paul John Beswick ,  David Kenneth Dean ,  Robert James Gleave ,  Andrew Peter Moses ,  Daryl Simon Walter

    IPC分类号： A61K31/4164 ,  C07D233/02

    CPC分类号： C07D233/36 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04

    摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐：该化合物或盐调节P2X7受体功能并能够拮抗ATP在P2X7受体（P2X7受体拮抗剂）下的作用。 本发明还提供了这样的化合物或其盐或其药物组合物在治疗或预防P2X7受体介导的病症/疾病中的用途，例如疼痛，炎症或神经变性疾病，特别是疼痛，例如炎性疼痛， 神经性疼痛或内脏痛。

    Piperidinone Carboxamide Derivatives as P2X7 Modulators
    10.
    发明申请
    Piperidinone Carboxamide Derivatives as P2X7 Modulators 审中-公开
    哌啶酮甲酰胺衍生物作为P2X7调节剂

    公开(公告)号：US20100168171A1

    公开(公告)日：2010-07-01

    申请号：US12593044

    申请日：2008-03-20

    申请人： Paul John Beswick ,  Robert James Gleave ,  Jon Graham Anthony Steadman ,  Daryl Simon Walter

    发明人： Paul John Beswick ,  Robert James Gleave ,  Jon Graham Anthony Steadman ,  Daryl Simon Walter

    IPC分类号： A61K31/45 ,  C07D211/78 ,  A61P29/00 ,  A61P25/28

    CPC分类号： C07D211/78

    摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The compounds or salts modulate P2X7 receptor function and are capable of interfering with the effects of ATP at the P2X7 receptor. The invention also provides the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease, in particular pain such as inflammatory pain, neuropathic pain or visceral pain.

    摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐：该化合物或盐调节P2X7受体功能并能够干扰ATP在P2X7受体上的作用。 本发明还提供了这样的化合物或其盐或其药物组合物在治疗或预防P2X7受体介导的病症中的用途，例如疼痛，炎症或神经变性疾病，特别是疼痛，例如炎性疼痛，神经性疼痛 或内脏痛。