公开(公告)号：US07834005B2

公开(公告)日：2010-11-16

申请号：US12370856

申请日：2009-02-13

申请人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

发明人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

IPC分类号： C07D487/04 ,  A61K31/551 ,  A61P31/00

CPC分类号： C07D487/04

摘要： Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

摘要翻译： 公开了式I的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p如本文所述; 包含式I化合物和载体的药物组合物; 一种抑制细胞生长的方法，该方法包括以有效抑制生长式I化合物的量给药; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的剂量施用式I化合物; 治疗细胞的病毒，寄生或细菌感染的方法，该方法包括以有效治疗式I化合物的病毒，寄生或细菌感染的量施用; 以及制备如本文所述的式I化合物的方法。

公开(公告)号：US20090149449A1

公开(公告)日：2009-06-11

申请号：US12370856

申请日：2009-02-13

申请人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

发明人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip W. Howard ,  Luke Y. Hsiao ,  Gregory Turner

IPC分类号： A61K31/551 ,  C07D487/04 ,  C12N5/06 ,  A61P31/04

CPC分类号： C07D487/04

摘要： Disclosed are compounds of Formula I wherein X, Y, R1-R7, T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

摘要翻译： 公开了式I的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p如本文所述; 包含式I化合物和载体的药物组合物; 一种抑制细胞生长的方法，该方法包括以有效抑制生长式I化合物的量给药; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的剂量施用式I化合物; 治疗细胞的病毒，寄生或细菌感染的方法，该方法包括以有效治疗式I化合物的病毒，寄生或细菌感染的量施用; 以及制备如本文所述的式I化合物的方法。

公开(公告)号：US07244724B2

公开(公告)日：2007-07-17

申请号：US11129207

申请日：2005-05-13

申请人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip Howard ,  Stephen Gregson

发明人： Paul S. Liu ,  B. Rao Vishnuvajjala ,  Kenneth M. Snader ,  David E. Thurston ,  Philip Howard ,  Stephen Gregson

IPC分类号： C07D403/12 ,  A61K31/5517

CPC分类号： C07D487/04

摘要： A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M′ are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.

摘要翻译： 式I化合物或其溶剂化物，其中n为1-10，M和M'独立地选自一价药学上可接受的阳离子，或一起代表二价药学上可接受的阳离子。