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公开(公告)号：US20100129315A1
公开(公告)日：2010-05-27
申请号：US12086320
申请日：2006-12-12
申请人： Paul Tamburini , Gerald Ranges Hamden , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges Hamden , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有针对MN蛋白特异性抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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公开(公告)号：US08168758B2
公开(公告)日：2012-05-01
申请号：US12086320
申请日：2006-12-12
申请人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
IPC分类号： C12P21/08
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有针对MN蛋白特异性抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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公开(公告)号：US20120301468A1
公开(公告)日：2012-11-29
申请号：US13459558
申请日：2012-04-30
申请人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
IPC分类号： C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods of using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有特异性针对MN蛋白的抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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4.发明授权Cyanopyridine derivatives useful in the treatment of cancer and other disorders 有权可用于治疗癌症和其他疾病的氰基吡啶衍生物公开(公告)号：US07557129B2
公开(公告)日：2009-07-07
申请号：US10788029
申请日：2004-02-27
申请人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
发明人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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5.发明申请SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 审中-公开用于治疗癌症和其他疾病的替代吡啶衍生物公开(公告)号：US20100075971A1
公开(公告)日：2010-03-25
申请号：US12628735
申请日：2009-12-01
申请人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
发明人： Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
IPC分类号： A61K31/4412 , C07D211/74 , C07D405/12 , C07D401/12 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4433 , A61K31/4709 , A61K31/4439 , A61K31/4545 , A61K31/5377
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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6.发明授权Bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的双环脲衍生物公开(公告)号：US08076488B2
公开(公告)日：2011-12-13
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger A. Smith , William J. Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： C07D213/62 , C07D401/00 , C07D417/00
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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7.发明申请Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders 有权用于治疗癌症和其他疾病的新型双环脲衍生物公开(公告)号：US20050038031A1
公开(公告)日：2005-02-17
申请号：US10788426
申请日：2004-03-01
申请人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
发明人： Jacques Dumas , Stephen Boyer , Sharad Verma , Lila Adnane , Yuanwei Chen , Wendy Lee , Barton Phillips , Roger Smith , William Scott , Jennifer Burke , Jianqing Chen , Zhi Chen , Jianmei Fan , Karl Miranda , Brian Raudenbush , Aniko Redman , Jianxing Shao , Ning Su , Gan Wang , Lin Yi , Qingming Zhu
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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