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公开(公告)号：US08188233B2
公开(公告)日：2012-05-29
申请号：US12322861
申请日：2009-02-06
Applicant: Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
Inventor： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC: C07K16/00 , A61K39/395 , C12N5/07 , C12N5/16
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20090232795A1
公开(公告)日：2009-09-17
申请号：US12322861
申请日：2009-02-06
Applicant: Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
Inventor： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20120219558A1
公开(公告)日：2012-08-30
申请号：US13497663
申请日：2010-09-15
Applicant: Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon , Fubao Wang
Inventor： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon , Fubao Wang
CPC classification number: C07K16/40 , C07K2317/76
Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (PCSK9) are disclosed. Said antagonists are effective in the inhibition of PCSK9 function and thereby provide compositions of matter useful for the treatment of conditions associated with PCSK9 activity. The present invention further discloses nucleic acids encoding PCSK9 antagonists as well as methods of making and using PCSK9 antagonists.
Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。 所述拮抗剂在抑制PCSK9功能方面是有效的，从而提供可用于治疗与PCSK9活性相关的病症的物质组合物。 本发明还公开了编码PCSK9拮抗剂的核酸以及制备和使用PCSK9拮抗剂的方法。
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公开(公告)号：US20070188860A1
公开(公告)日：2007-08-16
申请号：US11353752
申请日：2006-02-14
Applicant: Timothy McCabe
Inventor： Timothy McCabe
IPC: G02B23/00
CPC classification number: G02B23/18
Abstract: An improved binocular apparatus, system and method for presenting disparate fields of view is provided. The binocular apparatus and system differently magnifies optical transmissions pertaining to fields of view concurrently and simultaneously presents the optical transmissions pertaining to fields of view disparately.
Abstract translation: 提供了一种用于呈现不同视场的改进的双目镜装置，系统和方法。 双目镜装置和系统不同地同时放大属于视场的光传输，并且同时呈现与不同视野相关的光传输。
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公开(公告)号：US08748115B2
公开(公告)日：2014-06-10
申请号：US13139045
申请日：2009-12-02
Applicant: Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
Inventor： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
IPC: G01N33/573 , G01N33/543 , C07K16/40
CPC classification number: C07K16/40 , C07K2317/55 , G01N33/543 , G01N33/573 , G01N2333/96433
Abstract: Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay The immunoassay used can be a solid phase immunoassay, such as a dissociation-enhanced lanthanide fluorescence immunoassay utilizing an E07 capture antibody or coating and a G08 or H23 detecting antibody.
Abstract translation: 使用PCSK9拮抗剂的方法更具体地，通过免疫测定法测量生物样品中的循环PCSK9水平的方法使用的免疫测定法可以是固相免疫测定法，例如利用E07捕获抗体或涂层的解离增强镧系荧光免疫测定法 G08或H23检测抗体。
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Patent Agency Ranking
公开(公告)号：US20130071379A1
公开(公告)日：2013-03-21
申请号：US13466433
申请日：2012-05-08
Applicant: Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
Inventor： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Yoder , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peter Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
IPC: A61K39/395 , C07K16/40 , C07K16/30 , C12P21/02 , C12N5/07
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US08168758B2
公开(公告)日：2012-05-01
申请号：US12086320
申请日：2006-12-12
Applicant: Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
Inventor： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
IPC: C12P21/08
CPC classification number: C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
Abstract: The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
Abstract translation: 本发明提供具有针对MN蛋白特异性抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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公开(公告)号：US08957194B2
公开(公告)日：2015-02-17
申请号：US13466433
申请日：2012-05-08
Applicant: Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
Inventor： Jon H. Condra , Rose M. Cubbon , Holly A. Hammond , Timothy McCabe , Shilpa Pandit , Laurence B. Peterson , Joseph C. Santoro , Ayesha Sitlani , Dana D. Wood , Henryk Mach , Heidi Pixley , Sonia M. Gregory , Jeffrey T. Blue , Kevin Wang , Peizhi (Peter) Luo , Denise K. Nawrocki , Pingyu Zhong , Feng Dong , Yan Li
CPC classification number: C07K16/40 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/6424
Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20120301468A1
公开(公告)日：2012-11-29
申请号：US13459558
申请日：2012-04-30
Applicant: Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
Inventor： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
IPC: C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395
CPC classification number: C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
Abstract: The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods of using such antibodies in treating and diagnosing an MN-related disorder.
Abstract translation: 本发明提供具有特异性针对MN蛋白的抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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公开(公告)号：US20110306060A1
公开(公告)日：2011-12-15
申请号：US13139045
申请日：2009-12-02
Applicant: Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
Inventor： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
IPC: G01N33/573
CPC classification number: C07K16/40 , C07K2317/55 , G01N33/543 , G01N33/573 , G01N2333/96433
Abstract: Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a bio-logical sample by means of an immunoassay The immunoassay used can be a solid phase immunoassay, such as a dissociation-enhanced lanthanide fluorescence immunoassay utilizing an E07 capture antibody or coating and a G08 or H23 detecting antibody.
Abstract translation: 使用PCSK9拮抗剂的方法更具体地，通过免疫测定法测量生物逻辑样品中的循环PCSK9水平的方法所用的免疫测定可以是固相免疫测定法，例如利用E07捕获抗体的解离增强镧系荧光免疫测定法 涂层和G08或H23检测抗体。
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