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公开(公告)号：US06512101B1
公开(公告)日：2003-01-28
申请号：US09136351
申请日：1998-08-19
申请人： Dalton King , Raymond A. Firestone , Pamela Trail
发明人： Dalton King , Raymond A. Firestone , Pamela Trail
IPC分类号： C07H1702
CPC分类号： C07D207/452 , A61K47/54 , A61K47/6889 , C07C281/02 , C07H15/252
摘要： Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
摘要翻译： 用于将靶向配体如抗体与治疗活性药物连接的支链腙接头。 支链点在多价原子上，并且对于每一代分支，药物的数量增加了2倍。 优选的药物是多柔比星。
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公开(公告)号：US08168758B2
公开(公告)日：2012-05-01
申请号：US12086320
申请日：2006-12-12
申请人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy Mccabe , Pamela Trail , Sha Ha
IPC分类号： C12P21/08
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有针对MN蛋白特异性抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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3.发明申请公开(公告)号：US20060247186A1
公开(公告)日：2006-11-02
申请号：US11480360
申请日：2006-07-05
申请人： Christopher Carter , Neil Gibson , Barbara Hibner , Rachel Humphrey , Pamela Trail , Patrick Vincent , Yifan Zhai
发明人： Christopher Carter , Neil Gibson , Barbara Hibner , Rachel Humphrey , Pamela Trail , Patrick Vincent , Yifan Zhai
IPC分类号： A61K31/4412 , A61K31/7072 , A61K31/704 , A61K31/337 , A61K31/4745
CPC分类号： C07D213/81 , A61K31/337 , A61K31/435 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/535 , A61K31/65 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.
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4.发明申请ARYL UREA COMPOUNDS IN COMBINATION WITH OTHER CYTOSTATIC OR CYTOTOXIC AGENTS FOR TREATING HUMAN CANCERS 审中-公开与治疗人类癌症的其他细胞毒性或细胞毒素组合的ARYL UREA化合物公开(公告)号：US20120040925A1
公开(公告)日：2012-02-16
申请号：US13189945
申请日：2011-07-25
申请人： Christopher A. Carter , Neil Gibson , Barbara Hibner , Rachel W. Humphrey , Pamela Trail , Patrick W. Wincent , Yifan Zhai
发明人： Christopher A. Carter , Neil Gibson , Barbara Hibner , Rachel W. Humphrey , Pamela Trail , Patrick W. Wincent , Yifan Zhai
IPC分类号： A61K31/7068 , A61P35/00
CPC分类号： C07D213/81 , A61K31/337 , A61K31/435 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/535 , A61K31/65 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： This invention relates to aryl urea compounds in combination with cytotoxic or cytostatic agents for use in treating raf kinase mediated diseases such as cancer.
摘要翻译： 本发明涉及芳基脲化合物与用于治疗raf激酶介导的疾病如癌症的细胞毒性或细胞抑制剂的组合。
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公开(公告)号：US5824805A
公开(公告)日：1998-10-20
申请号：US770614
申请日：1996-12-19
申请人： Dalton King , Raymond A. Firestone , Pamela Trail
发明人： Dalton King , Raymond A. Firestone , Pamela Trail
IPC分类号： A61K31/00 , A61K31/40 , A61K31/401 , A61K31/4015 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K39/395 , A61K47/48 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07C281/02 , C07D207/44 , C07D207/452 , C07H15/252 , C07D207/40 , C07C243/28
CPC分类号： C07D207/452 , A61K47/48023 , A61K47/48715 , C07C281/02 , C07H15/252
摘要： Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.
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公开(公告)号：US20120301468A1
公开(公告)日：2012-11-29
申请号：US13459558
申请日：2012-04-30
申请人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
IPC分类号： C07K16/30 , G01N33/574 , A61P35/00 , A61K39/395
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods of using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有特异性针对MN蛋白的抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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公开(公告)号：US20100129315A1
公开(公告)日：2010-05-27
申请号：US12086320
申请日：2006-12-12
申请人： Paul Tamburini , Gerald Ranges Hamden , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
发明人： Paul Tamburini , Gerald Ranges Hamden , Lila Adnane , Timothy McCabe , Pamela Trail , Sha Ha
CPC分类号： C07K16/40 , A61K39/395 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention provides antibodies having an antigenic binding site specifically directed against an MN protein, and methods for using such antibodies in treating and diagnosing an MN-related disorder.
摘要翻译： 本发明提供具有针对MN蛋白特异性抗原结合位点的抗体，以及使用这些抗体治疗和诊断MN相关病症的方法。
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