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公开(公告)号：US07883841B2
公开(公告)日：2011-02-08
申请号：US11812152
申请日：2007-06-15
摘要： Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analyses of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compound and radiation and numerous other possible therapies.
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2.发明授权Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue 失效用于测试相对于肿瘤细胞和组织的三维基质中治疗化合物和其它疗法的疗效的方法和试剂盒公开(公告)号：US07977041B2
公开(公告)日：2011-07-12
申请号：US11812152
申请日：2007-06-15
CPC分类号： G01N33/5029 , G01N33/5011 , G01N33/5088 , G01N2800/52
摘要： Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analyses of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compound and radiation and numerous other possible therapies.
摘要翻译： 提供了用于加速设计，测试和评估肿瘤治疗的三维生理基质，方法，仪器和试剂盒。 本发明的关键方面包括基质，特别是凝胶基质，其包含一种或多种生理纤维，其适于和布置成提供允许行为的条件，例如细胞从目标组织的样品的边缘移动通过基质 ，以产生可用于评估细胞的肿瘤状态和特征的数据的方式进行评估。 在另一关键方面，本发明允许对特定靶组织或细胞的一种或多种常规，实验或理论疗法的体外测试和分析。 在这些疗法中，治疗化合物及其组合，放射疗法，治疗化合物和辐射的组合以及许多其它可能的疗法。
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3.发明授权公开(公告)号：US08007991B2
公开(公告)日：2011-08-30
申请号：US11812128
申请日：2007-06-15
CPC分类号： G01N33/5088 , G01N2800/52
摘要： Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the movement of cells away from the margins of samples of target tissue through the matrix, to be evaluated in a manner that produces data useful for evaluating the oncological status and characteristics of the cells. In a further key aspect, the invention permits the in vitro testing and analysis of one or more conventional, experimental or theoretical therapies with respect to specific target tissues or cells. Among such therapies are therapeutic compounds and combinations thereof, radiation therapies, combinations of therapeutic compounds and radiation and numerous other possible therapies.
摘要翻译： 提供了用于加速设计，测试和评估肿瘤治疗的三维生理基质，方法，仪器和试剂盒。 本发明的关键方面包括基质，特别是凝胶基质，其包含一种或多种生理纤维，其适于和布置成提供允许行为的条件，例如细胞从目标组织的样品的边缘移动通过基质 ，以产生可用于评估细胞的肿瘤状态和特征的数据的方式进行评估。 在另一个关键方面，本发明允许体外测试和分析关于特定靶组织或细胞的一种或多种常规的实验或理论疗法。 在这些疗法中，治疗化合物及其组合，放射疗法，治疗化合物和辐射的组合以及许多其它可能的疗法。
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