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    Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones
    1.
    发明授权
    Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones 有权
    取代的吡唑并[3,4-d]嘧啶-4,6-二酮

    公开(公告)号：US08846693B2

    公开(公告)日：2014-09-30

    申请号：US12746231

    申请日：2008-12-06

    Applicant: Peng Li ,  Jun Zhao ,  Hailin Zheng

    Inventor： Peng Li ,  Jun Zhao ,  Hailin Zheng

    IPC: C07D487/04 ,  A61K31/519 ,  A61P25/24 ,  A61P25/22 ,  A61P15/10 ,  A61P9/12

    CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

    Abstract: 1- or 2- or 7-(substituted)-3-(optionally hetero)arylamino-[1H,2H]-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives, in free, salt or prodrug form, are useful as pharmaceuticals, particularly as phosphodiesterase 1 inhibitors, useful for the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy and damage to cognitive function, e.g., in schizophrenia or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction.

    Abstract translation: 1-或2-或7-（取代的）-3-（任选杂）芳基氨基 - [1H，2H] - 吡唑并[3,4-d]嘧啶-4,6（5H，7H） - 二酮衍生物 ，盐或前药形式，可用作药物，特别是作为磷酸二酯酶抑制剂，可用于治疗涉及多巴胺D1受体细胞内途径疾病的疾病，例如帕金森病，抑郁症，发作性睡病和对认知功能的损害，例如， 精神分裂症或通过增强的孕激素信号传导途径可能改善的疾病，例如女​​性性功能障碍。

    ORGANIC COMPOUNDS
    2.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20130331363A1

    公开(公告)日：2013-12-12

    申请号：US13701244

    申请日：2011-05-31

    Applicant: Peng Li ,  Jun Zhao

    Inventor： Peng Li ,  Jun Zhao

    IPC: A61K31/519 ,  A61K45/06 ,  A61K31/5575 ,  C07D487/14

    CPC classification number: A61K31/519 ,  A61K31/5575 ,  A61K45/06 ,  C07D487/14

    Abstract: Optionally substituted (1- or 3-oxy)-4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-imidazo[1,2-a]pyrrolo[3,4-e]pyrimidine or (1- or 3-oxy)-4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-2H-pyrimido[1,2-a]pyrrolo[3,4-e]pyrimidine compounds, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising the same.

    Abstract translation: 任选取代的（1-或3-氧）-4,5,7,8-四氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-咪唑并[1,2-a]吡咯并[ 4-e]嘧啶或（1-或3-氧）-4,5,7,8,9-五氢 - （任选4-氧代，4-硫代或4-亚氨基）-2H-嘧啶并[1,2- a]吡咯并[3,4-e]嘧啶化合物，其制备方法，它们作为药物的用途和包含其的药物组合物。

    Organic compounds
    6.
    发明授权
    Organic compounds 有权
    有机化合物

    公开(公告)号：US09556185B2

    公开(公告)日：2017-01-31

    申请号：US13701235

    申请日：2011-05-31

    Applicant: Peng Li ,  Hailin Zheng ,  Jun Zhao ,  Lawrence P. Wennogle

    Inventor： Peng Li ,  Hailin Zheng ,  Jun Zhao ,  Lawrence P. Wennogle

    IPC: A61K31/165 ,  A61K31/573 ,  A61K31/565 ,  A61K31/557 ,  A61K31/519 ,  A61K31/19 ,  C07D487/04 ,  C07D487/14 ,  A61K45/06

    CPC classification number: C07D487/14 ,  A61K31/165 ,  A61K31/19 ,  A61K31/519 ,  A61K31/557 ,  A61K31/565 ,  A61K31/573 ,  A61K45/06 ,  C07D487/04

    Abstract: The present invention relates to optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds, and methods of using said compound, e.g., wherein the treatment relates to diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as, among others, Parkinson's disease, depression, narcolepsy, damage to cognitive function, e.g., in schizophrenia.

    Abstract translation: 本发明涉及任选取代的4,5,7,8-四氢 - （任选4-氧代，4-硫代或4-亚氨基） - （1H或2H） - 咪唑并[1,2-a]吡唑并[ 3-e]嘧啶或4,5,7,8,9-五氢 - （任选4-氧代，4-硫代或4-亚氨基） - （1H或2H） - 嘧啶并[1,2-a]吡唑并[4 ，3-e]嘧啶化合物，以及使用所述化合物的方法，例如，其中治疗涉及涉及多巴胺D1受体细胞内途径紊乱的疾病，例如帕金森病，抑郁症，发作性睡病，对认知功能的损害 ，例如精神分裂症。

    PDE1 inhibitor compounds
    7.
    发明授权
    PDE1 inhibitor compounds 有权
    PDE1抑制剂化合物

    公开(公告)号：US09434730B2

    公开(公告)日：2016-09-06

    申请号：US13701284

    申请日：2011-05-31

    Applicant: Peng Li ,  Jun Zhao

    Inventor： Peng Li ,  Jun Zhao

    IPC: C07D487/04 ,  A61K45/06 ,  A61K31/519

    CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

    Abstract: The present invention relates to (1- or 2- and/or 5 and/or 7-substituted)-(3-oxy)-(4H,4-imino, 4-thioxo or 4-oxo)-pyrazolo[3,4-d]pyrimidin-6-ones, e.g., a compound of formula II as described below, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. Of particular interest are novel compounds useful as inhibitors of phosphodiesterase 1 (PDE1), e.g., in the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy, damage to cognitive function, e.g., in schizophrenia, or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction.

    Abstract translation: 本发明涉及（1-或2-和/或5和/或7-取代的） - （3-氧） - （4H，4-亚氨基，4-硫代或4-氧代） - 吡唑并[3,4 -d]嘧啶-6-酮，例如下述的式II化合物，其制备方法，它们作为药物的用途和包含它们的药物组合物。 特别令人感兴趣的是可用作磷酸二酯酶1（PDE1）抑制剂的新化合物，例如用于治疗涉及多巴胺D1受体细胞内途径紊乱的疾病，例如帕金森病，抑郁症，发作性睡病，对认知功能的损害，例如 精神分裂症或可通过增强的孕激素信号传导途径改善的疾病，例如女​​性性功能障碍。

    ORGANIC COMPOUNDS
    9.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20130338124A1

    公开(公告)日：2013-12-19

    申请号：US13701284

    申请日：2011-05-31

    Applicant: Peng Li ,  Jun Zhao

    Inventor： Peng Li ,  Jun Zhao

    IPC: C07D487/04 ,  A61K45/06 ,  A61K31/519

    CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06

    Abstract: The present invention relates to (1- or 2- and/or 5 and/or 7-substituted)-(3-oxy)-(4H, 4-imino, 4-thioxo or 4-oxo)-pyrazolo[3,4-d]pyrimidin-6-ones, e.g., a compound of formula II as described below, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. Of particular interest are novel compounds useful as inhibitors of phosphodiesterase 1 (PDE1), e.g., in the treatment of diseases involving disorders of the dopamine D1 receptor intracellular pathway, such as Parkinson's disease, depression, narcolepsy, damage to cognitive function, e.g., in schizophrenia, or disorders that may be ameliorated through enhanced progesterone-signaling pathway, e.g., female sexual dysfunction.

    Abstract translation: 本发明涉及（1-或2-和/或5和/或7-取代的） - （3-氧） - （4H，4-亚氨基，4-硫代或4-氧代） - 吡唑并[3,4 -d]嘧啶-6-酮，例如下述的式II化合物，其制备方法，它们作为药物的用途和包含它们的药物组合物。 特别令人感兴趣的是可用作磷酸二酯酶1（PDE1）抑制剂的新化合物，例如用于治疗涉及多巴胺D1受体细胞内途径紊乱的疾病，例如帕金森病，抑郁症，发作性睡病，对认知功能的损害，例如 精神分裂症或可通过增强的孕激素信号传导途径改善的疾病，例如女​​性性功能障碍。

    ORGANIC COMPOUNDS
    10.
    发明申请
    ORGANIC COMPOUNDS 有权
    有机化合物

    公开(公告)号：US20130324565A1

    公开(公告)日：2013-12-05

    申请号：US13701225

    申请日：2011-05-31

    Applicant: Peng Li ,  Jun Zhao

    Inventor： Peng Li ,  Jun Zhao

    IPC: C07D487/04 ,  A61K31/165 ,  A61K45/06 ,  A61K31/519

    CPC classification number: C07D487/04 ,  A61K31/165 ,  A61K31/519 ,  A61K31/5575 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention relates to optionally substituted (5- or 7-oxy)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)-1H-pyrrolo[3,4-d]pyrimidin-2(3H,6H)-ones, e.g., Compounds of Formula II-A′ or II-B′ as described herein, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them.

    Abstract translation: 本发明涉及任选取代的（5-或7-氧）-3,4-二氢 - （任选4-氧代，4-硫代或4-亚氨基）-1H-吡咯并[3,4-d]嘧啶-2 （3H，6H） - 酮，例如本文所述的式II-A'或II-B'的化合物，其制备方法，其用作药物和包含它们的药物组合物。

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