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公开(公告)号：US20050209334A1
公开(公告)日：2005-09-22
申请号：US11040611
申请日：2005-01-19
IPC分类号： A61K31/195
CPC分类号： A61K31/196 , A61K31/192 , A61K31/337 , A61K2300/00
摘要： The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.
摘要翻译： 本发明提供了使用苯甲酸衍生物单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。 还提供了基于其抑制酪氨酸酶或结合并激活PXR / SXR异生物受体的能力筛选苯甲酸衍生物的方法。
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公开(公告)号：US20120329861A1
公开(公告)日：2012-12-27
申请号：US13470819
申请日：2012-05-14
IPC分类号： A61K31/192 , A61K31/195 , A61K31/24 , A61M37/00 , C12N5/09 , A61K31/337 , A61P35/00 , A61K31/135 , A61K31/235
CPC分类号： A61K31/196 , A61K31/192 , A61K31/337 , A61K2300/00
摘要： The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.
摘要翻译： 本发明提供了使用苯甲酸衍生物单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。 还提供了基于其抑制酪氨酸酶或结合并激活PXR / SXR异生物受体的能力筛选苯甲酸衍生物的方法。
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公开(公告)号：US09018259B2
公开(公告)日：2015-04-28
申请号：US13470819
申请日：2012-05-14
IPC分类号： A61K31/196 , A61K31/337 , A61K31/192
CPC分类号： A61K31/196 , A61K31/192 , A61K31/337 , A61K2300/00
摘要： The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.
摘要翻译： 本发明提供了使用苯甲酸衍生物单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。 还提供了基于其抑制酪氨酸酶或结合并激活PXR / SXR异生物受体的能力筛选苯甲酸衍生物的方法。
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公开(公告)号：US08198328B2
公开(公告)日：2012-06-12
申请号：US11040611
申请日：2005-01-19
IPC分类号： A61K31/195
CPC分类号： A61K31/196 , A61K31/192 , A61K31/337 , A61K2300/00
摘要： The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.
摘要翻译： 本发明提供了使用苯甲酸衍生物单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。 还提供了基于其抑制酪氨酸酶或结合并激活PXR / SXR异生物受体的能力筛选苯甲酸衍生物的方法。
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公开(公告)号：US07705049B2
公开(公告)日：2010-04-27
申请号：US11044638
申请日：2005-01-20
申请人： Peter C. Brooks , Leonard Liebes , Elissa Kramer , Bruce Ng , Danielle Morais
发明人： Peter C. Brooks , Leonard Liebes , Elissa Kramer , Bruce Ng , Danielle Morais
IPC分类号： A61K31/192
CPC分类号： A61K45/06 , A61K31/136 , A61K41/00 , A61K2300/00
摘要： The present invention relates to a method for treating non-melanotic cancers by administration of PABA. The present invention also relates to the potentiation of standard cancer treatment of radiation, radioimmunotherapy, and/or chemotherapy using PABA.
摘要翻译： 本发明涉及通过施用PABA治疗非黑素瘤的方法。 本发明还涉及使用PABA对辐射，放射免疫治疗和/或化学疗法的标准癌症治疗的增强。
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公开(公告)号：US20050220705A1
公开(公告)日：2005-10-06
申请号：US11044638
申请日：2005-01-20
申请人： Peter Brooks , Leonard Liebes , Elissa Kramer , Bruce Ng
发明人： Peter Brooks , Leonard Liebes , Elissa Kramer , Bruce Ng
IPC分类号： A61K31/195 , A61K31/337 , A61K31/4745 , A61K31/7072 , A61K33/24 , A61K51/00 , A61N5/00
CPC分类号： A61K45/06 , A61K31/136 , A61K41/00 , A61K2300/00
摘要： The present invention relates to a method for treating non-melanotic cancers by administration of PABA. The present invention also relates to the potentiation of standard cancer treatment of radiation, radioimmunotherapy, and/or chemotherapy using PABA.
摘要翻译： 本发明涉及通过施用PABA治疗非黑素瘤的方法。 本发明还涉及使用PABA对辐射，放射免疫治疗和/或化学疗法的标准癌症治疗的增强。
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公开(公告)号：US08710099B2
公开(公告)日：2014-04-29
申请号：US13394593
申请日：2010-09-10
申请人： Peter C. Brooks , James Canary , Leonard Liebes
发明人： Peter C. Brooks , James Canary , Leonard Liebes
IPC分类号： A61K31/195 , C07C63/64
CPC分类号： A61K31/195
摘要： The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.
摘要翻译： 本发明提供了使用苯甲酸衍生物的钠盐单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。
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公开(公告)号：US20120203051A1
公开(公告)日：2012-08-09
申请号：US13394593
申请日：2010-09-10
申请人： Peter C. Brooks , James Canary , Leonard Liebes
发明人： Peter C. Brooks , James Canary , Leonard Liebes
IPC分类号： A61K31/196 , A61P35/00 , A61N5/00 , A61K31/337
CPC分类号： A61K31/195
摘要： The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.
摘要翻译： 本发明提供了使用苯甲酸衍生物的钠盐单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。
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