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    Chiral piperidine and quinucledine ligands
    7.
    发明授权
    Chiral piperidine and quinucledine ligands 失效
    手性哌啶和奎宁配体

    公开(公告)号：US07491544B2

    公开(公告)日：2009-02-17

    申请号：US10441262

    申请日：2003-05-20

    申请人： James Canary ,  Zhaohua Dai

    发明人： James Canary ,  Zhaohua Dai

    IPC分类号： G01N33/20 ,  G01N21/76 ,  G01N33/53 ,  G01N21/64 ,  G01N21/66

    CPC分类号： G01N31/22 ,  Y10S436/80

    摘要： Zn(II) is selectively detected in a sample by contacting the sample with a tripodal ligand with a piperidine or quinuclidine scaffold, one of which acts as a zinc sensor, in which the rigidity of the ligand scaffold is increased. The rigidity of the ligand scaffold can be increased by adding aromatic groups or cyclic hydrocarbon groups. Examples of aromatic groups include naphthalene and the like. Examples of cyclic groups include nitrogen-substituted cyclohexane and cyclohexene such as piperidine.

    摘要翻译： 通过使样品与三齿配体与哌啶或奎宁环支架接触，选择性地检测Zn（II），其中一个作为锌传感器，其中配体支架的刚度增加。 通过添加芳族基团或环状烃基可以增加配体支架的刚性。 芳香族基团的实例包括萘等。 环状基团的实例包括氮取代的环己烷和环己烯如哌啶。

    8-Hydroxyquinoline tripodal metal ion probes
    9.
    发明申请
    8-Hydroxyquinoline tripodal metal ion probes 有权
    8-羟基喹啉三价金属离子探针

    公开(公告)号：US20050227365A1

    公开(公告)日：2005-10-13

    申请号：US11086987

    申请日：2005-03-23

    申请人： James Canary ,  Maksim Royzen

    发明人： James Canary ,  Maksim Royzen

    IPC分类号： G01N33/20 ,  C07D41/14

    CPC分类号： C07D401/14

    摘要： Highly sensitive fluorescent zinc or cadmium sensors are derived from 8-hydroxyquinaldine, a well-established fluorescent zinc probe, as a building block. High binding efficiency was achieved by incorporating two 8-hydroxyquninaldine moieties into a single ligand. Incorporation of sulfonamide groups further improved binding efficiency. The compounds make it possible to monitor zinc ion or cadmium ion concentration in the picomolar or femtomolar range.

    摘要翻译： 高灵敏度的荧光锌或镉传感器来自8-羟基喹哪啶，一种成熟的荧光锌探针，作为结构单元。 通过将两个8-羟基喹喔啉部分并入单个配体中来实现高结合效率。 磺酰胺基团的结合进一步提高了结合效率。 这些化合物可以监测皮摩尔或飞摩尔范围内的锌离子或镉离子浓度。