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公开(公告)号：US20120208792A1
公开(公告)日：2012-08-16
申请号：US13315103
申请日：2011-12-08
IPC分类号： A61K31/4745 , A61K31/5377 , A61K31/497 , C12N5/09 , A61P35/00 , A61P35/02 , A61P29/00 , A61K31/496 , A61K31/551
CPC分类号： C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US08168651B2
公开(公告)日：2012-05-01
申请号：US12396084
申请日：2009-03-02
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US20090239859A1
公开(公告)日：2009-09-24
申请号：US12396084
申请日：2009-03-02
IPC分类号： A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号： C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US07816406B2
公开(公告)日：2010-10-19
申请号：US11228636
申请日：2005-09-16
申请人： Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , Johnny Y. Nagasawa , Peter Chua
发明人： Jeffrey P. Whitten , Fabrice Pierre , Collin Regan , Michael Schwaebe , Johnny Y. Nagasawa , Peter Chua
IPC分类号： C07D471/22 , A61K31/437 , A61K31/4365
CPC分类号： C07D215/56 , C07D471/14 , C07D513/04 , C07D513/14
摘要： The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same.
摘要翻译： 本发明提供可抑制细胞增殖和/或诱导细胞凋亡的喹诺酮类似物。 本发明还提供制备喹诺酮类似物的方法及其使用方法。
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公开(公告)号：US07834180B2
公开(公告)日：2010-11-16
申请号：US12274302
申请日：2008-11-19
IPC分类号： C07D513/22 , C07D487/22 , C07D471/22 , C07D471/14 , C07D498/22 , A61P35/00 , A61P43/00
CPC分类号： C07D471/14 , C07D495/14 , C07D513/14
摘要： Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1, W, X, B′, R and n are as defined herein.
摘要翻译： 具有式1的化合物是通过在非亲核性碱存在下使式（6A）化合物与式（7）化合物或其互变异构体接触来制备的，其中V，A，Z，L， W，X，B'，R和n如本文所定义。
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公开(公告)号：US20090082565A1
公开(公告)日：2009-03-26
申请号：US12274302
申请日：2008-11-19
IPC分类号： C07D471/22
CPC分类号： C07D471/14 , C07D495/14 , C07D513/14
摘要： The present invention relates to the preparation of compounds which are capable of inducing cell death such as apoptotic cell death (apoptosis), and/or for reducing a cell proliferative disorder.
摘要翻译： 本发明涉及能够诱导细胞死亡的化合物的制备，例如凋亡细胞死亡（凋亡）和/或用于减少细胞增殖性疾病。
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公开(公告)号：US07816524B2
公开(公告)日：2010-10-19
申请号：US11499076
申请日：2006-08-04
IPC分类号： C07D491/22 , C07D471/22 , C07D471/14 , C07D513/22 , C07D498/22 , A61P35/00
CPC分类号： C07D471/14 , C07D495/14 , C07D513/14
摘要： Compounds having formula 1 are produced by contacting a compound having formula(6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, wherein V, A, Z, L, L1,W, X, B′, R and N are as defined herein.
摘要翻译： 具有式1的化合物通过在非亲核碱的存在下使式（6A）化合物与式（7）化合物或其互变异构体接触来制备，其中V，A，Z，L，L 1，W ，X，B'，R和N如本文所定义。
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公开(公告)号：US08703810B2
公开(公告)日：2014-04-22
申请号：US13702394
申请日：2011-06-08
IPC分类号： A61K31/4025 , C07D405/10
CPC分类号： A61K31/352 , A61K31/4025 , A61K31/403 , A61K31/4178 , A61K31/439 , A61K31/453 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D311/60 , C07D405/12 , C07D407/14 , C07D471/08 , C07D487/08
摘要： Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
摘要翻译： 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独和与其它化合物组合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。
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公开(公告)号：US08455534B2
公开(公告)日：2013-06-04
申请号：US13613467
申请日：2012-09-13
申请人： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Celine Bonnefous
发明人： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Celine Bonnefous
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04
摘要： Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20130012561A1
公开(公告)日：2013-01-10
申请号：US13613467
申请日：2012-09-13
申请人： Nicholas D. SMITH , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Celine Bonnefous
发明人： Nicholas D. SMITH , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Celine Bonnefous
IPC分类号： A61K31/416 , A61P35/00
CPC分类号： C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04
摘要： Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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