公开(公告)号：US20060223827A1

公开(公告)日：2006-10-05

申请号：US10550982

申请日：2004-03-26

申请人： Peter Davis ,  Matthew Naylor ,  Peter Thomson ,  Steven Everett ,  Michael Stratford ,  Peter Wardman

发明人： Peter Davis ,  Matthew Naylor ,  Peter Thomson ,  Steven Everett ,  Michael Stratford ,  Peter Wardman

IPC分类号： A61K31/496 ,  A61K31/404 ,  A61K31/381 ,  C07D333/22 ,  C07D403/02 ,  C07D209/04

CPC分类号： C07D333/44 ,  C07D209/12

摘要： A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3); R1 is hydrogen, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; R2 is alkyl, alkoxy, thialkoxy or halo; R3, R4 and R5 are each independently alkyl, alkoxy, thialkoxy or halo with the proviso that at least two of R3, R4 or R5 are alkoxy; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is O, S or NR7; Y is hydrogen, alkyl, alkoxy, thialkoxy, halo, hydroxy or dihydrogenphosphate; R6 is hydrogen or alkyl; R7 is hydrogen or alkyl; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; R10 is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11, and R12 are independently hydrogen, alkyl, alkoxy, thialkoxy, amono alkylamino, dialkylamino, morpholino, alkylmorpholino, piperidino, alkylpiperidiono, piperazino, alkylpiperazino or 1-aziridinyl; and A, together with the carbon atoms to which it is fused, is an optionally substituted aryl or heteroaryl ring.

摘要翻译： 式（1）化合物或其药学上可接受的盐，其中Ar是带有至少一个硝基或叠氮基的取代杂芳基，或者是式（2）或（3）的基团。 R 1是氢，任选取代的烷基，任选取代的芳基或任选取代的杂芳基; R 2是烷基，烷氧基，硫烷氧基或卤素; R 3，R 4和R 5各自独立地为烷基，烷氧基，硫烷氧基或卤素，条件是R _{3，R 4或R 5是烷氧基; L是-OC（O） - 或-OP（O）（OR 6） - ; n为0或1; X是O，S或NR 7; Y是氢，烷基，烷氧基，硫烷氧基，卤素，羟基或磷酸二氢酯; R 6是氢或烷基; R 7是氢或烷基; R 8是氢，烷氧基或二烷基氨基烷基; R 9是任选取代的烷基; R 10是氢，烷基，烷氧基或二烷基氨基烷基; R 11和R 12独立地是氢，烷基，烷氧基，硫烷氧基，氨基烷基氨基，二烷基氨基，吗啉代，烷基吗啉代，哌啶子基，烷基哌啶子基，哌嗪基，烷基哌嗪基或1-氮丙啶基 ; 和A与其稠合的碳原子一起是任选取代的芳基或杂芳基环。}

公开(公告)号：US20070099871A1

公开(公告)日：2007-05-03

申请号：US10550864

申请日：2004-03-26

申请人： Peter Davis ,  Matthew Naylor ,  Peter Thomson ,  Steven Everett ,  Michael Stratford ,  Peter Wardman

发明人： Peter Davis ,  Matthew Naylor ,  Peter Thomson ,  Steven Everett ,  Michael Stratford ,  Peter Wardman

IPC分类号： A61K31/675 ,  A61K31/404 ,  A61K31/122 ,  A61K31/137 ,  A61K31/66 ,  C07F9/572 ,  C07F9/28 ,  C07D403/02

CPC分类号： C07D409/04 ,  A61K31/445 ,  C07D233/91 ,  C07D333/42 ,  C07D473/38

摘要： The present invention relates to a compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein: Ar is a substituted aryl or heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or (3) wherein R1, and R2, which may be the same or different are independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, aryl, COR3 or, together with the intervening carbon atom, form an optionally substituted heterocycloalkyl or carbocyclic ring; L is —OC(O)— or —OP(O)(OR6)—; n is 0 or 1; X is 0, S, NR7 or a single covalent bond; R3 is OR4 or NR4R5; R4, R5, R6 and R7 are each independently hydrogen or optionally substituted alkyl or, where Rr is NR4R5, R4 and R5 can be joined to form, together with the intervening nitrogen atom, a heterocycloalkyl ring; R8 is hydrogen, alkoxy or dialkylaminoalkyl; R9 is optionally substituted alkyl; Rio is hydrogen, alkyl, alkoxy or dialkylaminoalkyl; R11 and R12 are independently hydrogen, alkyl, alkoxy, thioalkoxy, amino, alkylamino, dialkylamino, morpholino, piperidino, piperazino or 1=aziridinyl; A is an optionally substituted aryl or heteroaryl ring; and Dr is a moiety such that DrXH represents a cytotoxic or cytostatic compound.

摘要翻译： 本发明涉及式（1）化合物或其药学上可接受的盐，其中：Ar是具有至少一个硝基或叠氮基的取代的芳基或杂芳基，或者是式（2）或（3）的基团 ）其中R 1，R 2和R 2可以相同或不同，独立地为任选取代的烷基，任选取代的烯基，任选取代的炔基，芳基， 或者与插入的碳原子一起形成任选取代的杂环烷基或碳环; L是-OC（O） - 或-OP（O）（OR 6） - ; n为0或1; X是0，S，NR 7或单个共价键; R 3是OR 4或NR 4 R 5; R 4，R 5，R 6和R 7各自独立地为氢或任选取代的烷基，或其中 R 1是NR 4 R 5，R 4和R 5可以是 与杂环氮原子一起形成杂环烷基环; R 8是氢，烷氧基或二烷基氨基烷基; R 9是任选取代的烷基; R 3为氢，烷基，烷氧基或二烷基氨基烷基; R 11和R 12独立地是氢，烷基，烷氧基，硫代烷氧基，氨基，烷基氨基，二烷基氨基，吗啉代，哌啶子基，哌嗪基或1 =氮丙啶基; A是任选取代的芳基或杂芳基环; Dr是一个部分，使得DrXH代表细胞毒性或细胞抑制性化合物。

公开(公告)号：US20220318846A1

公开(公告)日：2022-10-06

申请号：US17707783

申请日：2022-03-29

申请人： Steven Everett

发明人： Steven Everett

IPC分类号： G06Q30/02

摘要： The present invention provides methods and systems for facilitating promotion of a content based on playing an audio. The present invention includes a process of receiving a promotional content from a user device; transmitting the promotional content to a second user device; selecting a promotional content based on the at least one indication; transmitting a promotional content to a promoter device; generating a promotional content notification, wherein the promotional content notification includes statistical representations of the audience data; and transmitting the promotional content notification to the user device, the promoter device and the second user device.