公开(公告)号：US20090062362A1

公开(公告)日：2009-03-05

申请号：US12259844

申请日：2008-10-28

申请人： Peter Frank Ekhart ,  Mario Van Wandelen ,  Jan Matthijs Jetten

发明人： Peter Frank Ekhart ,  Mario Van Wandelen ,  Jan Matthijs Jetten

IPC分类号： A61K31/4184 ,  A61P33/10

CPC分类号： A61K9/1075 ,  A61K31/415 ,  A61K47/36 ,  A61K47/44

摘要： This invention concerns a method for the preparation of a suspoemulsion formulation, which can be easily produced on an industrial scale and which allows the reproducible and effective administration of one or more water-insoluble veterinary drugs through water distribution systems. The water-insoluble veterinary drug, in finely ground form, is dispersed in a water immiscible liquid, followed by homogenisation of this system into a water phase. To facilitate the preparation of a stable formulation, one or more stabilising agents such as emulsifiers, thickeners, anti-oxidants and anti-microbials can be used. The resulting suspoemulsion shows excellent long term storage stability and a good “in use” stability after dilution in a vessel and during all handling and transport in the water distribution system.

摘要翻译： 本发明涉及一种制备悬乳剂制剂的方法，其可以容易地以工业规模生产并且允许通过配水系统可重复和有效地施用一种或多种水不溶性兽药。 将精细研磨形式的水不溶性兽药分散在与水不混溶的液体中，随后将该体系均质化成水相。 为了促进制备稳定的制剂，可以使用一种或多种稳定剂如乳化剂，增稠剂，抗氧化剂和抗微生物剂。 所得到的悬乳剂在容器中稀释后以及在配水系统中的所有处理和运输期间都显示出优异的长期储存稳定性和良好的“使用中”稳定性。

公开(公告)号：US08465788B2

公开(公告)日：2013-06-18

申请号：US13059293

申请日：2009-08-18

申请人： Peter Frank Ekhart ,  Hans Van Der Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D Cani

发明人： Peter Frank Ekhart ,  Hans Van Der Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D Cani

IPC分类号： A23G3/00

CPC分类号： A61K31/7034 ,  A21D2/181 ,  A23L33/135 ,  A23L33/22 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/73 ,  A61K31/715 ,  A61Q19/00 ,  C08B37/0057 ,  C08L5/00 ,  A23V2250/502 ,  A23V2250/5028 ,  A23V2200/3202

摘要： The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such as Bifidobacterium or Lactobacillus.

摘要翻译： 本发明涉及特定的阿拉伯木聚糖（“AX”）制剂，并且发现该制剂对肠腔中尤其是在肠粘膜部位的肠微生物群落的组织具有有益作用，其中它调节 肠表面的屏障功能，主要是通过调节粘膜相关的微生物群落相对增加健康益菌，如双歧杆菌和乳杆菌。 因此，本发明的第一方面是提供所述阿拉伯木聚糖制剂，其特征在于包含分离的水溶性阿拉伯木聚糖及其用于改善肠上皮的功能（例如屏障功能）的用途。 因此，在另一方面，本发明提供了包含所述阿拉伯木聚糖制剂的组合物，包括药物和营养组合物; 特别是药物，医疗食品，食品添加剂或食品组合物，例如婴儿配方食品，乳制品，面包店产品或糕点产品。 组合物任选地包含益生菌如双歧杆菌或乳杆菌。

公开(公告)号：US20120230955A1

公开(公告)日：2012-09-13

申请号：US13059293

申请日：2009-08-18

申请人： Peter Frank Ekhart ,  Hans Van De Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D. Cani

发明人： Peter Frank Ekhart ,  Hans Van De Saag ,  Sam Possemiers ,  Pieter Van Den Abbeele ,  Tom Van De Wiele ,  Audrey Martine Neyrinck ,  Nathalie Maria Nelly Delzenne ,  Patrice D. Cani

IPC分类号： A61K38/16 ,  A61P1/00 ,  A61P37/00 ,  A61P9/00 ,  A61P3/04 ,  A61K35/74 ,  A61P3/00

CPC分类号： A61K31/7034 ,  A21D2/181 ,  A23L33/135 ,  A23L33/22 ,  A23L33/40 ,  A23V2002/00 ,  A61K8/73 ,  A61K31/715 ,  A61Q19/00 ,  C08B37/0057 ,  C08L5/00 ,  A23V2250/502 ,  A23V2250/5028 ,  A23V2200/3202

摘要： The present invention is directed to a particular arabinoxylan (“AX”) preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such as Bifidobacterium or Lactobacillus.

摘要翻译： 本发明涉及特定的阿拉伯木聚糖（“AX”）制剂，并且发现该制剂对肠腔中尤其是在肠粘膜部位的肠微生物群落的组织具有有益作用，其中它调节 肠表面的屏障功能，主要是通过调节粘膜相关的微生物群落相对增加健康益菌，如双歧杆菌和乳杆菌。 因此，本发明的第一方面是提供所述阿拉伯木聚糖制剂，其特征在于包含分离的水溶性阿拉伯木聚糖及其用于改善肠上皮的功能（例如屏障功能）的用途。 因此，在另一方面，本发明提供了包含所述阿拉伯木聚糖制剂的组合物，包括药物和营养组合物; 特别是药物，医疗食品，食品添加剂或食品组合物，例如婴儿配方食品，乳制品，面包店产品或糕点产品。 组合物任选地包含益生菌如双歧杆菌或乳杆菌。

公开(公告)号：US09040571B2

公开(公告)日：2015-05-26

申请号：US12259844

申请日：2008-10-28

申请人： Peter Frank Ekhart ,  Mario Van Wandelen ,  Jan Matthijs Jetten

发明人： Peter Frank Ekhart ,  Mario Van Wandelen ,  Jan Matthijs Jetten

IPC分类号： A01N43/52 ,  A61K31/415 ,  A61K9/107 ,  A61K47/36 ,  A61K47/44

CPC分类号： A61K9/1075 ,  A61K31/415 ,  A61K47/36 ,  A61K47/44

摘要： This invention concerns a method for the preparation of a suspoemulsion formulation, which can be easily produced on an industrial scale and which allows the reproducible and effective administration of one or more water-insoluble veterinary drugs through water distribution systems. The water-insoluble veterinary drug, in finely ground form, is dispersed in a water immiscible liquid, followed by homogenization of this system into a water phase. To facilitate the preparation of a stable formulation, one or more stabilizing agents such as emulsifiers, thickeners, anti-oxidants and anti-microbials can be used. The resulting suspoemulsion shows excellent long term storage stability and a good “in use” stability after dilution in a vessel and during all handling and transport in the water distribution system.

摘要翻译： 本发明涉及一种制备悬乳剂制剂的方法，其可以容易地以工业规模生产并且允许通过配水系统可重复和有效地施用一种或多种水不溶性兽药。 将精细研磨形式的水不溶性兽药分散在与水不混溶的液体中，随后将该体系均质化成水相。 为了促进制备稳定的制剂，可以使用一种或多种稳定剂如乳化剂，增稠剂，抗氧化剂和抗微生物剂。 所得到的悬乳剂在容器中稀释后以及在配水系统中的所有处理和运输期间都显示出优异的长期储存稳定性和良好的“使用中”稳定性。

公开(公告)号：US20110045073A1

公开(公告)日：2011-02-24

申请号：US12867481

申请日：2009-02-19

申请人： Peter Frank Ekhart

发明人： Peter Frank Ekhart

IPC分类号： A61K9/14 ,  A61K31/16 ,  A61K38/02 ,  A61K31/688 ,  A61P1/02 ,  A61P31/00

CPC分类号： A61K31/688 ,  A23G3/364 ,  A23G4/12 ,  A23J7/00 ,  A23L33/115 ,  A23V2002/00 ,  A61K9/0056 ,  A61K31/133 ,  A61K38/1729 ,  A61K2300/00 ,  A23V2200/30

摘要： The present invention relates to controlled release composition for preventing and/or treating microbial infections in the oral cavity of a subject, said composition comprising a controlled delivery matrix which matrix has releasably associated therewith an amount of between 0.000009 and 5 wt % of a sphingolipid, wherein the composition provides a sphingolipid-release-profile in the oral cavity of a subject, wherein said release-profile is maintained for between 15 seconds and 24 hours and wherein said release-profile provides for a concentration of said sphingolipid in the saliva of said subject of between 20 μmole/L and 250 μmole/L.

摘要翻译： 本发明涉及用于预防和/或治疗受试者口腔微生物感染的控释组合物，所述组合物包含受控的递送基质，该基质可释放地与其相关联，其量为鞘脂的0.000009至5重量％ 其中所述组合物在受试者的口腔中提供鞘脂释放曲线，其中所述释放曲线保持在15秒和24小时之间，并且其中所述释放曲线提供所述鞘脂在所述口腔中的浓度 对象为20μmole/ L和250μmole/ L。

公开(公告)号：US06475541B1

公开(公告)日：2002-11-05

申请号：US09567719

申请日：2000-05-10

申请人： Peter Frank Ekhart ,  Johannes Bernardus Lenssinck

发明人： Peter Frank Ekhart ,  Johannes Bernardus Lenssinck

IPC分类号： A21D1004

CPC分类号： A23L17/75 ,  A23L13/03 ,  A23L29/212 ,  A23P20/12

摘要： The invention relates to a batter mix comprising genetically modified potato starch (GMPS), a process for the production of said batter mix, the use of said batter mix for the production of food products comprising said batter mix, preferably batter coated food products, which may be pre-fried, frozen and then preferably cooked in a microwave oven, whereby the use of the genetically modified potato starch in the batter mix compositions results in unexpected superior crispness of the food product.

摘要翻译： 本发明涉及包含转基因马铃薯淀粉（GMPS），生产所述面糊混合物的方法的面糊混合物，所述面糊混合物用于生产包含所述面糊混合物，优选面糊包衣食品的食品的使用， 可以预炒，冷冻，然后优选在微波炉中烹饪，由此在面糊混合组合物中使用转基因马铃薯淀粉导致食品的意想不到的优异的脆性。