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公开(公告)号：US5739115A
公开(公告)日：1998-04-14
申请号：US312571
申请日：1994-09-26
IPC分类号： A61K31/70 , A61K31/737 , A61P9/00 , A61P27/02 , A61P35/00 , C07H11/00 , C08B37/00 , C07H15/00
CPC分类号： A61K31/70 , A61K31/715 , A61K31/737 , C07H11/00 , Y10S514/824
摘要： A novel class of highly sulfated maltooligosaccharide having heparin-like activity is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, and retinopathies.
摘要翻译： 描述了具有肝素样活性的新一类高度硫酸化的麦芽低聚糖，以及使用这些寡糖来治疗某些疾病，包括癌症和视网膜病变的方法。
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2.发明申请Treatment of Carcinomas with a Combination of EGF-Pathway and Telomerase Inhibitors 有权用EGF途径和端粒酶抑制剂组合治疗癌公开(公告)号：US20100104586A1
公开(公告)日：2010-04-29
申请号：US12530014
申请日：2008-03-06
申请人： Robert J. Tressler , Ning F. Go
发明人： Robert J. Tressler , Ning F. Go
IPC分类号： A61K39/395 , C12N5/071 , A61P35/00
CPC分类号： A61K39/39558 , A61K31/7088 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of carcinoma cells are disclosed, based on a combination of an EGF pathway inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the antibody alone or the telomerase inhibitor alone.
摘要翻译： 基于EGF途径抑制剂和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用抗体或端粒酶抑制剂单独获得的抗癌治疗功效。
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3.发明授权Treatment of carcinomas with a combination of EGF-pathway and telomerase inhibitors 有权用EGF途径和端粒酶抑制剂联合治疗癌症公开(公告)号：US09155753B2
公开(公告)日：2015-10-13
申请号：US12530014
申请日：2008-03-06
申请人： Robert J. Tressler , Ning F. Go
发明人： Robert J. Tressler , Ning F. Go
IPC分类号： A61K31/7088 , A61K39/395 , A61K45/06
CPC分类号： A61K39/39558 , A61K31/7088 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of carcinoma cells are disclosed, based on a combination of an EGF pathway inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the antibody alone or the telomerase inhibitor alone.
摘要翻译： 基于EGF途径抑制剂和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用抗体或端粒酶抑制剂单独获得的抗癌治疗功效。
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4.发明授权公开(公告)号：US07989428B2
公开(公告)日：2011-08-02
申请号：US12446931
申请日：2007-10-30
申请人： Ning F. Go , Robert J. Tressler
发明人： Ning F. Go , Robert J. Tressler
CPC分类号： C12N15/1137 , A61K31/7068 , A61K31/7088 , C12N2310/11 , C12N2310/3145 , C12N2310/3515 , C12N2320/31 , C12Y207/07049 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a gemcitabine and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with gemcitabine alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.
摘要翻译： 基于吉西他滨和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用吉西他滨或端粒酶抑制剂单独获得的抗癌治疗功效。 优选地，相对于各个试剂的组合效应，效力是相对于辅助的或协同的，并且副作用的加剧最小化。
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5.发明申请公开(公告)号：US20100016407A1
公开(公告)日：2010-01-21
申请号：US12446931
申请日：2007-10-30
申请人： Ning F. Go , Robert J. Tressler
发明人： Ning F. Go , Robert J. Tressler
IPC分类号： A61K31/7088
CPC分类号： C12N15/1137 , A61K31/7068 , A61K31/7088 , C12N2310/11 , C12N2310/3145 , C12N2310/3515 , C12N2320/31 , C12Y207/07049 , A61K2300/00
摘要： A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a gemcitabine and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with gemcitabine alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.
摘要翻译： 基于吉西他滨和端粒酶抑制剂的组合，公开了抑制癌细胞增殖的方法和试剂盒。 当用于癌症治疗时，两种化合物组合增强了单独使用吉西他滨或端粒酶抑制剂单独获得的抗癌治疗功效。 优选地，相对于各个试剂的组合效应，效力是相对于辅助的或协同的，并且副作用的加剧最小化。
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