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公开(公告)号：US20080076784A1
公开(公告)日：2008-03-27
申请号：US11597585
申请日：2005-05-27
IPC分类号： A61K31/435 , A61K31/437 , A61K31/517 , A61P43/00 , C07D221/04 , C07D239/70 , C07D471/04
CPC分类号： C07D221/04 , C07D217/02 , C07D239/74 , C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) (I*) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译： 本申请涉及通式（I）（I *）的新型杂环化合物，其中R 1，R 2，R 2，X，Y，Z和n具有 描述中定义的含义，其制备方法和这些化合物作为药物的用途，特别是芳香酶抑制剂。
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公开(公告)号：US20070066582A1
公开(公告)日：2007-03-22
申请号：US11522316
申请日：2006-09-18
申请人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Nathalie Jotterand , Michael Quirmbach , Christoph Schumacher
发明人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Nathalie Jotterand , Michael Quirmbach , Christoph Schumacher
IPC分类号： A61K31/55 , A61K31/54 , A61K31/5375 , A61K31/538 , A61K31/496 , A61K31/497 , A61K31/495 , A61K31/50 , A61K31/505
CPC分类号： A61K31/404 , Y02A50/411
摘要： Use of compounds of the general formula (I) wherein R1, R2, R3, R4, R5, R6 and X have the definitions elucidated in more detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.
摘要翻译： 通式（I）的化合物其中R 1，R 2，R 3，R 4，R 4， R 5，R 6和X的定义在说明书中更详细地描述为β-分泌酶，组织蛋白酶D，浆细胞素II和/或HIV蛋白酶抑制剂。
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3.发明申请FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开熔融咪唑衍生物及其作为阿糖胞苷合成酶抑制剂的用途公开(公告)号：US20100168145A1
公开(公告)日：2010-07-01
申请号：US11921313
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/438 , C07D471/10 , C07D471/20 , A61P5/42
CPC分类号： C07D471/04
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译： 该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，X，Y，Z，n和p具有在说明书中更详细阐述的定义涉及制备方法 它们以及这些化合物作为药物的使用，特别是作为醛固酮合酶抑制剂。
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4.发明授权公开(公告)号：US07612088B2
公开(公告)日：2009-11-03
申请号：US11597620
申请日：2005-05-27
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , C07D417/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译： 本申请涉及通式（I）的新型杂环化合物，其中R，R 1，R 2，W，X，Y，Z和n具有本说明书中定义的含义，其制备方法和使用 这些化合物作为药物，特别是作为醛固酮合酶抑制剂。
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5.发明申请公开(公告)号：US20080076794A1
公开(公告)日：2008-03-27
申请号：US11597615
申请日：2005-05-27
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Dirk Behnke , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Dirk Behnke , Michael Quirmbach
IPC分类号： A61K31/4184 , A61P5/38 , C07D515/04
CPC分类号： C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译： 本申请涉及通式（I）的新型杂环化合物，其中R 1，R 2，R 2，X，Y，Z和n具有如下定义的含义： 描述，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合酶抑制剂。
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6.发明申请公开(公告)号：US20100029694A1
公开(公告)日：2010-02-04
申请号：US12585584
申请日：2009-09-18
IPC分类号： A61K31/517 , A61K31/437 , A61P5/40
CPC分类号： C07D471/04 , C07D417/04
摘要： Heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the meanings defined in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译： R 1，R 2，W，X，Y，Z和n具有本说明书中定义的含义的通式（I）的杂环化合物，其制备方法和这些化合物作为药物的用途，特别是 作为醛固酮合酶抑制剂。
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公开(公告)号：US20090111840A1
公开(公告)日：2009-04-30
申请号：US11921312
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/438 , C07D401/14 , A61P9/12
CPC分类号： C07D471/20
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译： 该专利申请涉及通式（I）的新的杂环化合物，其中R，R 1，R 2，W，X，Y，Z和n具有在说明书中更详细阐述的定义，及其制备方法 使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。
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公开(公告)号：US08071774B2
公开(公告)日：2011-12-06
申请号：US11921311
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： C07D491/20 , A61K31/438
CPC分类号： C07D471/04 , C07D471/10 , C07D491/10
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, U, V, W, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译： 该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，U，V，W，X，Y，Z，n和p具有在描述中更详细阐述的定义 ，其制备方法和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。
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公开(公告)号：US08071773B2
公开(公告)日：2011-12-06
申请号：US11921312
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： C07D471/20 , A61K31/438 , A61K31/437
CPC分类号： C07D471/20
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译： 该专利申请涉及通式（I）的新的杂环化合物，其中R，R 1，R 2，W，X，Y，Z和n具有在说明书中更详细阐述的定义，及其制备方法 使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。
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公开(公告)号：US20100010015A1
公开(公告)日：2010-01-14
申请号：US11921311
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/527 , A61K31/438 , A61K31/416 , C07D237/26 , C07D471/00 , C07D235/02
CPC分类号： C07D471/04 , C07D471/10 , C07D491/10
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, U, V, W, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译： 该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，U，V，W，X，Y，Z，n和p具有在描述中更详细阐述的定义 ，其制备方法和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。
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