公开(公告)号：US09149545B2

公开(公告)日：2015-10-06

申请号：US12276817

申请日：2008-11-24

申请人： Peter John Bonitatibus, Jr. ,  David Cheney deMoulpied ,  Andrew Soliz Torres ,  Amit Mohan Kulkarni ,  Robert Edgar Colborn ,  Paul William Buckley

发明人： Peter John Bonitatibus, Jr. ,  David Cheney deMoulpied ,  Andrew Soliz Torres ,  Amit Mohan Kulkarni ,  Robert Edgar Colborn ,  Paul William Buckley

IPC分类号： A61K49/04 ,  B82Y30/00 ,  C01G27/02 ,  C01G35/00 ,  C01G3/12 ,  B82Y5/00 ,  C09C3/12

CPC分类号： A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01G35/00 ,  C01P2004/04 ,  C01P2004/64 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.

摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。 本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。

公开(公告)号：US20090087383A1

公开(公告)日：2009-04-02

申请号：US12276817

申请日：2008-11-24

申请人： Peter John Bonitatibus, JR. ,  David Cheney deMoulpied ,  Andrew Soliz Torres ,  Amit Mohan Kulkarni ,  Robert Edgar Colborn ,  Paul William Buckley

发明人： Peter John Bonitatibus, JR. ,  David Cheney deMoulpied ,  Andrew Soliz Torres ,  Amit Mohan Kulkarni ,  Robert Edgar Colborn ,  Paul William Buckley

IPC分类号： A61K49/04

CPC分类号： A61K49/0423 ,  B82Y5/00 ,  B82Y30/00 ,  C01G27/02 ,  C01G35/00 ,  C01P2004/04 ,  C01P2004/64 ,  C09C3/12

摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.

摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。 本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。

公开(公告)号：US08147802B2

公开(公告)日：2012-04-03

申请号：US11864453

申请日：2007-09-28

申请人： Zhebo Ding ,  Brian James Grimmond ,  Michael Luttrell ,  Slawomir Rubinsztajn ,  David Cheney deMoulpied ,  Margaret L. Blohm

发明人： Zhebo Ding ,  Brian James Grimmond ,  Michael Luttrell ,  Slawomir Rubinsztajn ,  David Cheney deMoulpied ,  Margaret L. Blohm

IPC分类号： A61K49/06 ,  A61K49/18

CPC分类号： A61K49/1881 ,  B82Y5/00

摘要： Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also provided are methods of making such chelator-functionalized nanoparticles as well as imaging methods using the nanoparticles.

摘要翻译： 本文提供了包含被动芯的螯合剂官能化纳米颗粒; 以及在暴露于磁场时显示T1磁共振图案的活性涂层。 还提供了制备这种螯合官能官能化纳米颗粒的方法以及使用纳米颗粒的成像方法。

公开(公告)号：US20090087381A1

公开(公告)日：2009-04-02

申请号：US11864453

申请日：2007-09-28

申请人： Zhebo Ding ,  Brian James Grimmond ,  Michael Luttrell ,  Slawomir Rubinsztajn ,  David Cheney deMoulpied ,  Margaret L. Blohm

发明人： Zhebo Ding ,  Brian James Grimmond ,  Michael Luttrell ,  Slawomir Rubinsztajn ,  David Cheney deMoulpied ,  Margaret L. Blohm

IPC分类号： A61K49/06

CPC分类号： A61K49/1881 ,  B82Y5/00

摘要： Provided herein are chelator-functionalized nanoparticles comprising a passive core; and an active coating that demonstrate T1 magnetic resonance pattern upon exposure to a magnetic field. Also provided are methods of making such chelator-functionalized nanoparticles as well as imaging methods using the nanoparticles.

摘要翻译： 本文提供了包含被动芯的螯合剂官能化纳米颗粒; 以及在暴露于磁场时显示T1磁共振图案的活性涂层。 还提供了制备这种螯合官能官能化纳米颗粒的方法以及使用纳米颗粒的成像方法。