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1.发明授权Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same 有权用于X射线/计算机断层扫描的基于纳米颗粒的成像剂及其制备方法公开(公告)号：US09149545B2
公开(公告)日：2015-10-06
申请号：US12276817
申请日：2008-11-24
申请人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
发明人： Peter John Bonitatibus, Jr. , David Cheney deMoulpied , Andrew Soliz Torres , Amit Mohan Kulkarni , Robert Edgar Colborn , Paul William Buckley
CPC分类号： A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01G35/00 , C01P2004/04 , C01P2004/64 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.
摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。 本文包括形成这种试剂的方法，包括形成核/壳纳米颗粒的组合，其中核/壳纳米颗粒的整体的平均直径被选择为使得组合体中的纳米颗粒可以被哺乳动物肾基本上清除。
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公开(公告)号：US08728529B2
公开(公告)日：2014-05-20
申请号：US12344606
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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公开(公告)号：US08574549B2
公开(公告)日：2013-11-05
申请号：US12344608
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michacl Ernest Marino
IPC分类号： A61K49/04
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.
摘要翻译： 提供了用至少一个两性离子部分官能化的纳米颗粒的组合物，制备多种纳米颗粒的方法及其用作诊断剂的方法。 与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。 纳米颗粒包括具有基本上不含二氧化硅的核心表面的核心，以及附着于核心表面的壳体。 壳包含至少一个硅烷官能化的两性离子部分。
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4.发明授权Non-radioactive traceable metal isotope-enriched nanoparticles and method of their use for determining biodistribution 失效非放射性可追溯金属同位素富集纳米颗粒及其用于确定生物分布的方法公开(公告)号：US08246932B2
公开(公告)日：2012-08-21
申请号：US12057650
申请日：2008-03-28
申请人： Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
发明人： Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
IPC分类号： A61B5/055
CPC分类号： A61K49/1848 , B82Y5/00 , B82Y15/00 , G01N2458/15 , Y10T428/2991 , Y10T428/2993
摘要： Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.
摘要翻译： 提供了非放射性可溯源金属同位素富集纳米颗粒的组成及其用于确定体内生物分布的方法。 所述方法包括以下步骤：（a）将纳米颗粒引入生物材料中，其中所述纳米颗粒包含至少一种无机核，所述无机核包含至少两种预定比例的金属同位素; 其中至少一种金属同位素是富集的非放射性可追溯金属同位素，和（b）基于金属同位素的预定比例确定生物材料中纳米颗粒的分布。
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公开(公告)号：US08728440B2
公开(公告)日：2014-05-20
申请号：US13592853
申请日：2012-08-23
CPC分类号： A61K49/1848 , A61K49/04 , A61K49/0428 , B82Y5/00 , C07F7/1804 , C07F9/005 , Y10T428/2982
摘要： The present invention provides a trialkoxysilanes having structure I wherein R1 and R2 are independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1和R 2在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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公开(公告)号：US08821838B2
公开(公告)日：2014-09-02
申请号：US13592897
申请日：2012-08-23
IPC分类号： A61K49/04 , A61K31/695 , A61B5/055
CPC分类号： A61K49/0428 , B82Y5/00 , C07F7/1804 , Y10T428/2982
摘要： The present invention provides a trialkoxysilane having structure I wherein R1 is independently at each occurrence a C1-C3 alkyl group; R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group; R4 is a C1-C5 aliphatic radical, a C7-C12 aromatic radical, or a C5-C10 cycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and X− represents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.
摘要翻译： 本发明提供具有结构I的三烷氧基硅烷，其中R 1在每次出现时独立地为C 1 -C 3烷基; R 3在每次出现时独立地为氢或C 1 -C 3烷基; R4是C1-C5脂族基团，C7-C12芳族基团或C5-C10脂环族基团; n为0,1,2或3; q为1,2或3; t为0,1或2; X-表示电荷平衡抗衡离子。 三烷氧基硅烷可用于制备纳米颗粒诊断成像剂组合物。
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公开(公告)号：US08252317B2
公开(公告)日：2012-08-28
申请号：US12393101
申请日：2009-02-26
CPC分类号： C12N5/0068 , C12N2533/10 , C12N2533/74
摘要： The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.
摘要翻译： 本发明提供由非交联藻酸盐单体如藻酸钠和4,5,5或6族金属卤氧化物的水溶液制备的新型金属藻酸盐。 新型组4,5和6金属藻酸盐可用于制备细胞培养支持物，显示出有用的X射线对比性质，并且相对于已知的藻酸盐如藻酸钙，对标准高压釜条件显示出不期望的稳定性。 通常，由本发明提供的新型金属藻酸盐提供在已知的金属藻酸盐如钙或钡藻酸盐中未观察到的特征和性质。
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公开(公告)号：US09373433B2
公开(公告)日：2016-06-21
申请号：US13538229
申请日：2012-06-29
申请人： Francis Johnson , Robert Edgar Colborn , Judson Sloan Marte , Peter John Bonitatibus, Jr. , Binil Itty Ipe Kandapallil , Mohammed Haouaoui , Christina Chen
发明人： Francis Johnson , Robert Edgar Colborn , Judson Sloan Marte , Peter John Bonitatibus, Jr. , Binil Itty Ipe Kandapallil , Mohammed Haouaoui , Christina Chen
CPC分类号： H01F1/0579 , C22C1/02 , H01F1/0576 , H01F1/068 , H01F1/10 , H01F41/0273
摘要： A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.
摘要翻译： 提供了一种制备纳米复合永磁体的方法。 该方法包括对硬磁相纳米颗粒和软磁相纳米颗粒施加极端剪切变形以对准至少一部分硬相磁性颗粒并产生纳米复合永磁体。
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