利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.019 秒)

    Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
    2.
    发明授权
    Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment 失效
    甲状旁腺激素类似物在AA 25,26,27取代，用于骨质疏松症治疗

    公开(公告)号：US5317010A

    公开(公告)日：1994-05-31

    申请号：US773098

    申请日：1991-10-10

    申请人： Peter K. T. Pang ,  Jie Shan

    发明人： Peter K. T. Pang ,  Jie Shan

    IPC分类号： A61K38/22 ,  A61K38/00 ,  A61P3/00 ,  A61P19/10 ,  A61P43/00 ,  C07K14/575 ,  C07K14/635 ,  A61K37/36 ,  C07K7/10

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： Analogues of bovine and human parathyroid hormone, wherein twenty-fifth, twenty-six and twenty-seventh positions of the natural hormone, Arg-Lys-Lys- each have been substituted with Ala, Asn, Asp, Cys, Gln, Glu, Gly, His, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val have been found to retain bone cell effect with minimal effects on blood pressure and smooth muscle, including cardiac muscle. It has further been found that this effect can be obtained by using a synthetic PTH containing only the first 34 amino acids of PTH, with substitution at the twenty-fifth, twenty-sixth and twenty-seventh amino acids as described. These analogues of PTH also are effective in the treatment of osteoporosis and other bone diseases.

    摘要翻译： 牛和人甲状旁腺激素的类似物，其中天然激素Arg-Lys-Lys-的各自已被Ala，Asn，Asp，Cys，Gln，Glu，Gly取代的二十五，二十六和二十七位 已发现His，Ile，Leu，Met，Phe，Pro，Ser，Thr，Trp，Tyr或Val保留骨细胞效应，对血压和平滑肌（包括心肌）影响最小。 进一步已经发现，通过使用仅含有PTH的前34个氨基酸的合成PTH，如所述的第二十五，二十六和二十七个氨基酸的取代，可以获得该效果。 PTH的类似物也有效治疗骨质疏松症和其他骨疾病。