公开(公告)号：US20140187802A1

公开(公告)日：2014-07-03

申请号：US14195513

申请日：2014-03-03

申请人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

发明人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

IPC分类号： C07D307/48

CPC分类号： C07D307/48 ,  C07D307/46 ,  C07D307/50

摘要： The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

摘要翻译： 本发明描述了以纯或粗形式从糖类合成5-（氯甲基）-2-糠醛（CMF）的方法和装置，所述方法包括：（a）以纯或粗形式连续接触糖类，盐酸， 和有机溶剂，通过连续的双相流反应器组件在约60℃至约200℃的温度和约1大气压至约20个大气压的压力下进行，从而制备CMF; （b）通过液/液和固相/液相分离分离5-（氯甲基）-2-糠醛; （c）每天生产至少5公斤至少50％的产量。 本发明的实施方案可以连续地产生CMF，具有高产率并且不降解CMF至诸如5-（羟甲基）糠醛（HMF），2-（2-羟基乙酰基）呋喃（HAF）和乙酰丙酸 （LA）。

公开(公告)号：US09102644B2

公开(公告)日：2015-08-11

申请号：US14195513

申请日：2014-03-03

申请人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

发明人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

IPC分类号： C07D307/48 ,  C07D307/50

CPC分类号： C07D307/48 ,  C07D307/46 ,  C07D307/50

摘要： The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

摘要翻译： 本发明描述了以纯或粗形式从糖类合成5-（氯甲基）-2-糠醛（CMF）的方法和装置，所述方法包括：（a）以纯或粗形式连续接触糖类，盐酸， 和有机溶剂，通过连续的双相流反应器组件在约60℃至约200℃的温度和约1大气压至约20个大气压的压力下进行，从而制备CMF; （b）通过液/液和固相/液相分离分离5-（氯甲基）-2-糠醛; （c）每天生产至少5公斤至少50％的产量。 本发明的实施方案可以连续地产生CMF，具有高产率并且不降解CMF至诸如5-（羟甲基）糠醛（HMF），2-（2-羟基乙酰基）呋喃（HAF）和乙酰丙酸 （LA）。