公开(公告)号：US20100291485A1

公开(公告)日：2010-11-18

申请号：US12713148

申请日：2010-02-25

申请人： Troy Lapsys ,  Viswanath Krishnamoorthy ,  Paul Bentley ,  Uday Khire ,  Scott Miller ,  Peter Mikochik

发明人： Troy Lapsys ,  Viswanath Krishnamoorthy ,  Paul Bentley ,  Uday Khire ,  Scott Miller ,  Peter Mikochik

IPC分类号： G03F7/20 ,  C07H21/04

CPC分类号： C07H19/073 ,  C12P19/34

摘要： This invention relates to nanoscale molecule synthesis, including three-dimensional addressable arrays of biopolymeric nucleic acids and processes for manufacturing such arrays. Such arrays can be functionalized with complementary chemical reactive probes to provide catalytic enzymes.

摘要翻译： 本发明涉及纳米尺度分子合成，包括生物聚合物核酸的三维可寻址阵列和用于制造这种阵列的方法。 这样的阵列可以用互补的化学反应性探针进行功能化以提供催化酶。

公开(公告)号：US08710250B2

公开(公告)日：2014-04-29

申请号：US13817452

申请日：2011-08-17

申请人： Peter Mikochik ,  Aviad Cahana

发明人： Peter Mikochik ,  Aviad Cahana

IPC分类号： C07D307/02

CPC分类号： C07D307/68

摘要： The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.

摘要翻译： 本发明涉及由5-（氯甲基）-2-糠醛（CMF）合成5-甲基-2-糠酸，包括酯，酰胺和硫酯衍生物。 如此制备的分子可用作药物，食品和香料分子的中间体; 以及燃料或燃料添加剂。

公开(公告)号：US09102644B2

公开(公告)日：2015-08-11

申请号：US14195513

申请日：2014-03-03

申请人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

发明人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

IPC分类号： C07D307/48 ,  C07D307/50

CPC分类号： C07D307/48 ,  C07D307/46 ,  C07D307/50

摘要： The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

摘要翻译： 本发明描述了以纯或粗形式从糖类合成5-（氯甲基）-2-糠醛（CMF）的方法和装置，所述方法包括：（a）以纯或粗形式连续接触糖类，盐酸， 和有机溶剂，通过连续的双相流反应器组件在约60℃至约200℃的温度和约1大气压至约20个大气压的压力下进行，从而制备CMF; （b）通过液/液和固相/液相分离分离5-（氯甲基）-2-糠醛; （c）每天生产至少5公斤至少50％的产量。 本发明的实施方案可以连续地产生CMF，具有高产率并且不降解CMF至诸如5-（羟甲基）糠醛（HMF），2-（2-羟基乙酰基）呋喃（HAF）和乙酰丙酸 （LA）。

公开(公告)号：US20140194633A1

公开(公告)日：2014-07-10

申请号：US14192828

申请日：2014-02-27

申请人： Peter Mikochik ,  Aviad Cahana

发明人： Peter Mikochik ,  Aviad Cahana

IPC分类号： C07D307/68

CPC分类号： C07D307/68

摘要： The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.

摘要翻译： 本发明涉及由5-（氯甲基）-2-糠醛（CMF）合成5-甲基-2-糠酸，包括酯，酰胺和硫酯衍生物。 如此制备的分子可用作药物，食品和香料分子的中间体; 以及燃料或燃料添加剂。

公开(公告)号：US20150047251A1

公开(公告)日：2015-02-19

申请号：US14503450

申请日：2014-10-01

申请人： Peter Mikochik ,  Aviad Cahana

发明人： Peter Mikochik ,  Aviad Cahana

IPC分类号： C10L1/19 ,  C10L10/08 ,  C10L10/10 ,  C10L10/14 ,  C10L1/24 ,  C10L1/224

CPC分类号： C10L1/19 ,  C10L1/224 ,  C10L1/2443 ,  C10L10/08 ,  C10L10/10 ,  C10L10/14 ,  C10L2200/0259 ,  C10L2200/0263 ,  C10L2270/023 ,  C10L2270/026 ,  C10L2270/04

摘要： Ester derivatives of furoic acids and in particular of 5-methyl-2-furoic acid can be used as fuel as fuel additives. Such esters can be used to displace crude oil products such as gasoline, diesel, jet fuel, etc. As fuel additives, such esters had been shown to improve the performance of spark ignition internal combustion engines, compression ignition internal combustion engines. In addition, testing shows indications that said molecule will improve the performance of air breathing engines as well.

摘要翻译： 糠酸酯，特别是5-甲基-2-糠酸的酯衍生物可用作燃料作为燃料添加剂。 这样的酯可以用于置换原油产品如汽油，柴油，喷气燃料等。作为燃料添加剂，已经显示这种酯改善火花点火内燃机，压燃式内燃机的性能。 此外，测试显示所述分子也将改善空气呼吸发动机的性能。

公开(公告)号：US20130267719A1

公开(公告)日：2013-10-10

申请号：US13817452

申请日：2011-08-17

申请人： Peter Mikochik ,  Aviad Cahana

发明人： Peter Mikochik ,  Aviad Cahana

IPC分类号： C07D307/68

CPC分类号： C07D307/68

摘要： The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.

摘要翻译： 本发明涉及由5-（氯甲基）-2-糠醛（CMF）合成5-甲基-2-糠酸，包括酯，酰胺和硫酯衍生物。 如此制备的分子可用作药物，食品和香料分子的中间体; 以及燃料或燃料添加剂。

公开(公告)号：US09108940B2

公开(公告)日：2015-08-18

申请号：US14192828

申请日：2014-02-27

申请人： Peter Mikochik ,  Aviad Cahana

发明人： Peter Mikochik ,  Aviad Cahana

IPC分类号： C07D307/02 ,  C07D307/68

CPC分类号： C07D307/68

摘要： The present invention concerns the synthesis of 5-methyl-2-furoic acid, including ester, amide, and thioester derivatives of such from 5-(chloromethyl)-2-furaldehyde (CMF). The molecules so prepared are useful as intermediates for pharmaceutical, food, and fragrance molecules; as well as fuel or fuel additives.

摘要翻译： 本发明涉及由5-（氯甲基）-2-糠醛（CMF）合成5-甲基-2-糠酸，包括酯，酰胺和硫酯衍生物。 如此制备的分子可用作药物，食品和香料分子的中间体; 以及燃料或燃料添加剂。

公开(公告)号：US20140187802A1

公开(公告)日：2014-07-03

申请号：US14195513

申请日：2014-03-03

申请人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

发明人： Peter Mikochik ,  Aviad Cahana ,  Edward Nikitin ,  Jeremy Standiford ,  Kyle Ellis ,  Luzheng Zhang ,  Timothy George

IPC分类号： C07D307/48

CPC分类号： C07D307/48 ,  C07D307/46 ,  C07D307/50

摘要： The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

摘要翻译： 本发明描述了以纯或粗形式从糖类合成5-（氯甲基）-2-糠醛（CMF）的方法和装置，所述方法包括：（a）以纯或粗形式连续接触糖类，盐酸， 和有机溶剂，通过连续的双相流反应器组件在约60℃至约200℃的温度和约1大气压至约20个大气压的压力下进行，从而制备CMF; （b）通过液/液和固相/液相分离分离5-（氯甲基）-2-糠醛; （c）每天生产至少5公斤至少50％的产量。 本发明的实施方案可以连续地产生CMF，具有高产率并且不降解CMF至诸如5-（羟甲基）糠醛（HMF），2-（2-羟基乙酰基）呋喃（HAF）和乙酰丙酸 （LA）。