公开(公告)号：US20190144408A1

公开(公告)日：2019-05-16

申请号：US16002537

申请日：2018-06-07

申请人： MICROMIDAS, INC.

发明人： Alex B. WOOD ,  Makoto N. MASUNO ,  Ryan L. SMITH ,  John BISSELL ,  Dimitri A. HIRSCH-WEIL ,  Robert Joseph ARAIZA ,  Daniel R. HENTON ,  James H. PLONKA

IPC分类号： C07D307/46 ,  C07D307/50 ,  B01J27/10

CPC分类号： C07D307/46 ,  B01J27/10 ,  C07D307/50

摘要： The present disclosure provides methods to produce 5-(halomethyl)furfural, including 5-(chloromethyl)furfural, by acid-catalyzed conversion of C6 saccharides, including isomers thereof, polymers thereof, and certain derivatives thereof. The methods make use of acids with lower concentrations, and allows for conversion of sugars into 5-(halomethyl)furfural at higher temperatures and faster reaction or residence times.

公开(公告)号：US10011577B2

公开(公告)日：2018-07-03

申请号：US15022882

申请日：2014-09-19

申请人： MICROMIDAS, INC.

发明人： Alex B. Wood ,  Makoto N. Masuno ,  Ryan L. Smith ,  John Bissell ,  Dimitri A. Hirsch-Weil ,  Robert Joseph Araiza ,  Daniel R. Henton ,  James H. Plonka

IPC分类号： C07D307/46 ,  C07D307/50 ,  B01J27/10

CPC分类号： C07D307/46 ,  B01J27/10 ,  C07D307/50

摘要： The present disclosure provides methods to produce 5-(halomethyl)furfural, including 5-(chloromethyl)furfural, by acid-catalyzed conversion of C6 saccharides, including isomers thereof, polymers thereof, and certain derivatives thereof. The methods make use of acids with lower concentrations, and allows for conversion of sugars into 5-(halomethyl)furfural at higher temperatures and faster reaction or residence times.

公开(公告)号：US09783517B2

公开(公告)日：2017-10-10

申请号：US14661139

申请日：2015-03-18

申请人： Aviad Cahana ,  Tim Martin

发明人： Aviad Cahana ,  Tim Martin

IPC分类号： C07D307/68 ,  C07D307/48 ,  C07D307/50

CPC分类号： C07D307/68 ,  C07D307/48 ,  C07D307/50

摘要： The present invention describes methods and apparatuses for the synthesis of 5-(chloromethyl)-2-furaldehyde (CMF) from saccharides in pure or crude form, the method comprising: (a) continuously contacting saccharides in pure or crude form, hydrochloric acid, and an organic solvent, by way of a continuous, biphasic-flow reactor assembly at a temperature from about 60 degrees C. to about 200 degrees C. and pressures from about 1 atmosphere to about 20 atmospheres, such that CMF is produced; (b) separating 5-(chloromethyl)-2-furaldehyde by liquid/liquid and solid/liquid phase separation; (c) producing at least five kilograms per day with at least 50% yield. Embodiments of the present invention can produce CMF in a continuous fashion, with high yield and without degradation of CMF to such side products as 5-(hydroxymethyl)furfural (HMF), 2-(2-hydroxyacetyl)furan (HAF) and levulinic acid (LA).

公开(公告)号：US09783474B2

公开(公告)日：2017-10-10

申请号：US15032218

申请日：2014-10-27

申请人： PURDUE RESEARCH FOUNDATION

发明人： William Nicholas Delgass ,  Rakesh Agrawal ,  Fabio Henrique Ribeiro ,  Basudeb Saha ,  Sara Lynn Yohe ,  Mahdi M Abu-Omar ,  Trenton Parsell ,  Paul James Dietrich ,  Ian Michael Klein

IPC分类号： C07C41/18 ,  C10L1/02 ,  B01J23/60 ,  D21C9/00 ,  C08H7/00 ,  C08H8/00 ,  D21C3/22 ,  C07C41/01 ,  C07G1/00 ,  C07D307/48 ,  C07D307/50 ,  B01J21/18 ,  B01J23/652 ,  C07C1/22 ,  C07D307/46 ,  C10L1/04

CPC分类号： C07C41/18 ,  B01J21/18 ,  B01J21/185 ,  B01J23/60 ,  B01J23/6525 ,  C07C1/22 ,  C07C41/01 ,  C07C2521/18 ,  C07C2523/60 ,  C07C2523/64 ,  C07D307/46 ,  C07D307/48 ,  C07D307/50 ,  C07G1/00 ,  C08H6/00 ,  C08H8/00 ,  C10L1/02 ,  C10L1/04 ,  C10L2200/0469 ,  D21C3/222 ,  D21C9/00 ,  C07C43/23

摘要： Described herein are processes for one-step delignification and hydrodeoxygenation of lignin fraction a biomass feedstock. The lignin feedstock is derived from by-products of paper production and biorefineries. Additionally described is a process for converting biomass-derived oxygenates to lower oxygen-content compounds and/or hydrocarbons in the liquid or vapor phase in a reactor system containing hydrogen and a catalyst comprised of a hydrogenation function and/or an oxophilic function and/or an acid function. Finally, also described herein is a process for converting biomass-derived oxygenates to lower oxygen-content compounds and/or hydrocarbons in the liquid or vapor phase in a reactor system containing hydrogen and a catalyst comprised of a hydrogenation function and/or an oxophilic function and/or an acid function.

公开(公告)号：US20170240518A1

公开(公告)日：2017-08-24

申请号：US15502845

申请日：2015-08-13

申请人： SHELL OIL COMPANY

发明人： Juben Nemchand CHHEDA ,  Jean Paul Andre Marie Joseph Ghislain LANGE ,  Paul Richard WEIDER ,  Robert Lawrence BLACKBOURN

IPC分类号： C07D307/50 ,  C13K1/02 ,  C13K13/00

CPC分类号： C07D307/50 ,  C13K1/02 ,  C13K13/002

摘要： Furfural is produced from biomass material containing pentosan, in high yields, in a production process comprising treating the biomass with a solution containing at least one α-hydroxysulfonic acid thereby hydrolyzing the biomass to produce a product stream containing at least one C5-carbohydrate compound in monomeric and/or oligomeric form, and dehydrating the C5-carbohydrate compound in the presence of an acid, in a biphasic reaction medium comprising an aqueous phase and a water-immiscible organic phase, at a temperature in the range of from about 100° C. to about 250° C. to produce a dehydration product stream containing furfural. An aqueous stream is separated from the dehydration product that can be optionally recycled to the hydrolysis step.

公开(公告)号：US20170144962A1

公开(公告)日：2017-05-25

申请号：US15195404

申请日：2016-06-28

申请人： Rennovia, Inc.

发明人： Eric L. Dias ,  James A.W. SHOEMAKER ,  Thomas R. BOUSSIE ,  Vincent J. MURPHY

IPC分类号： C07C209/16 ,  C07C29/157 ,  C07D307/46

CPC分类号： C07C29/157 ,  C07C29/132 ,  C07C29/141 ,  C07C29/175 ,  C07C209/16 ,  C07D307/46 ,  C07D307/48 ,  C07D307/50 ,  C07C31/20 ,  C07C31/22 ,  C07C211/12

摘要： Processes are disclosed for the conversion of a carbohydrate source to hexamethylenediamine (HMDA) and to intermediates useful for the production of hexamethylenediamine and other industrial chemicals. HMDA is produced by direct reduction of a furfural substrate to 1,6-hexanediol in the presence of hydrogen and a heterogeneous reduction catalyst comprising Pt or by indirect reduction of a furfural substrate to 1,6-hexanediol wherein 1,2,6-hexanetriol is produced by reduction of the furfural substrate in the presence of hydrogen and a catalyst comprising Pt and 1,2,6-hexanediol is then converted by hydrogenation in the presence of a catalyst comprising Pt to 1,6 hexanediol, each process then proceding to the production of HMDA by known routes, such as amination of the 1,6 hexanediol. Catalysts useful for the direct and indirect production of 1,6-hexanediol are also disclosed.

公开(公告)号：US09637463B2

公开(公告)日：2017-05-02

申请号：US14805321

申请日：2015-07-21

申请人： MICROMIDAS, INC.

发明人： Makoto Nathanael Masuno ,  John Bissell, II ,  Ryan L. Smith ,  Brian Higgins ,  Alex B. Wood

IPC分类号： C07D307/46 ,  C07D307/50

CPC分类号： C07D307/50 ,  C07D307/46

摘要： The present disclosure provides methods to produce substituted furans (e.g., halomethylfurfural, hydroxymethylfurfural, and furfural), by acid-catalyzed conversion of biomass using a gaseous acid in a multiphase reactor, such as a fluidized bed reactor.

公开(公告)号：US09610279B2

公开(公告)日：2017-04-04

申请号：US15080899

申请日：2016-03-25

申请人： AMINO UP CHEMICAL CO., LTD.

发明人： Hiroshi Nishioka ,  Tomohiro Ito ,  Takahiro Maeda

IPC分类号： C07D405/12 ,  A61K31/341 ,  A61K31/4025 ,  A61K36/8965 ,  C07D307/48 ,  C07D307/50 ,  A23L19/00 ,  A23L33/105

CPC分类号： A61K31/4025 ,  A23L19/09 ,  A23L33/105 ,  A61K31/341 ,  A61K36/8965 ,  A61K2236/37 ,  A61K2236/39 ,  C07D307/48 ,  C07D307/50 ,  C07D405/12

摘要： A method for induction of a heat shock protein, anti-stress or regulation of an autonomic nerve comprises: administering a mammalian subject in need thereof a composition comprising an effective amount of hydroxymethylfurfural derivative of the following formula: wherein R is selected from the group consisting of formula (I): (II): HOOCCH2COCO—, (III): HOOCCH2CH2COCO—, and (IV): a hydrogen atom.

公开(公告)号：US09403787B2

公开(公告)日：2016-08-02

申请号：US13953191

申请日：2013-07-29

申请人： MITSUBISHI CHEMICAL CORPORATION

发明人： Toru Okoshi ,  Hideto Tsuji

IPC分类号： C07D307/50

CPC分类号： C07D307/50 ,  B01J21/04 ,  B01J21/063 ,  B01J21/066 ,  B01J21/08 ,  B01J21/12 ,  B01J21/16 ,  B01J23/14 ,  B01J23/30 ,  B01J27/053 ,  B01J27/16 ,  B01J27/18 ,  B01J27/182 ,  B01J27/1853 ,  B01J29/084 ,  B01J29/7007

摘要： An object of the present invention is to provide a method for suppressing the corrosion of a reactor and reducing waste in the production of 2-furaldehyde from a sugar raw material containing a hexose as a constituent component, and another object of the invention is to provide an industrially advantageous method for producing 2-furaldehyde, which suppresses a decrease in the activity of a catalyst in a case of using an acid catalyst and provides a higher yield. The present invention relates to a method for producing 2-furaldehyde comprising heating a sugar raw material containing a hexose as a constituent component in an aprotic polar solvent in the presence of a solid acid catalyst.

摘要翻译： 本发明的目的是提供一种抑制反应器腐蚀的方法，并减少从含有己糖作为构成成分的糖原料生产2-糠醛的废物，本发明的另一个目的是提供 这是用于生产2-糠醛的工业上有利的方法，其抑制了在使用酸催化剂的情况下催化剂的活性降低并提供更高的收率。 本发明涉及一种生产2-糠醛的方法，包括在固体酸催化剂存在下，将含有己糖作为组成成分的糖原料加热到非质子极性溶剂中。

公开(公告)号：US09388150B2

公开(公告)日：2016-07-12

申请号：US14385919

申请日：2013-03-15

申请人： KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY ,  SNU R&DB FOUNDATION

发明人： Baek Jin Kim ,  Jin Ku Cho ,  Sangyong Kim ,  Do Hoon Lee ,  Young Gyu Kim ,  Eun-Sil Kang ,  Yeon-Woo Hong ,  Da Won Chae

IPC分类号： C07D307/48 ,  C07D307/50

CPC分类号： C07D307/50 ,  C07D307/48

摘要： The present invention relates to a method for preparing 5-acetoxymethylfurfural, comprising a step of synthesizing 5-acetoxymethylfurfural by reacting 5-halomethyl furfural with alkylammonium acetate. The present invention can provide a method for preparing 5-acetoxymethylfurfural which is economic and has high reaction efficiency even without using an additional base.

摘要翻译： 本发明涉及一种制备5-乙酰氧基甲基糠醛的方法，包括通过使5-卤代甲基糠醛与烷基乙酸铵反应合成5-乙酰氧甲基糠醛的步骤。 本发明可以提供一种经济地制备5-乙酰氧基甲基糠醛的方法，即使不使用额外的碱也具有高的反应效率。