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    Production of solid drug forms
    3.
    发明授权
    Production of solid drug forms 失效
    生产固体药物形式

    公开(公告)号：US6051253A

    公开(公告)日：2000-04-18

    申请号：US886286

    申请日：1997-07-01

    申请人： Hans Dieter Zettler ,  Michael Schiessl ,  Jorg Breitenbach ,  Joerg Rosenberg

    发明人： Hans Dieter Zettler ,  Michael Schiessl ,  Jorg Breitenbach ,  Joerg Rosenberg

    IPC分类号： A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

    CPC分类号： B30B11/227 ,  A61J3/06 ,  A61K9/2095 ,  B30B11/22 ,  A61J2200/20

    摘要： Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.

    摘要翻译： 固体药物形式通过在不存在溶剂的情况下混合和熔化至少一种药理学上可接受的聚合物粘合剂和至少一种药物活性成分（含或不含常规药物添加剂）以产生塑料混合物并将混合物成形为所需药物 通过挤出形成，其中成型在两个步骤中进行，挤出物在第一步骤中被破碎成成型制品，并且这些成形制品在塑性状态的第二步骤中被倒圆。

    Process for producing filaments from melamine/formaldehyde condensation products
    4.
    发明授权
    Process for producing filaments from melamine/formaldehyde condensation products 失效
    从三聚氰胺/甲醛缩合产物生产长丝的方法

    公开(公告)号：US5916999A

    公开(公告)日：1999-06-29

    申请号：US930172

    申请日：1997-10-09

    申请人： Heinz Berbner ,  Hartmut Gihr ,  Uwe Rachwalsky ,  Hans Dieter Zettler

    发明人： Heinz Berbner ,  Hartmut Gihr ,  Uwe Rachwalsky ,  Hans Dieter Zettler

    IPC分类号： C08G12/32 ,  C08G12/30

    CPC分类号： C08G12/32

    摘要： A process for producing continuous filament fibers from a hydroxy- or amino-alkyl-melamine modified melamine-formaldehyde condensation product comprises filtering the highly concentrated aqueous solution of the melamine-formaldehyde condensation product, forcing the filtrate through a spinneret, drying the extruded filaments in a drying shaft by means of hot air, and treating the dried filaments in a tempering oven at temperatures which rise gradually to a maximum temperature of from 160 to 250.degree. C. to cure the precondensate.

    摘要翻译： PCT No.PCT / EP96 / 01677 Sec。 371日期1997年10月9日第 102（e）日期1997年10月9日PCT 1996年4月22日提交PCT从羟基或氨基烷基 - 三聚氰胺改性的三聚氰胺 - 甲醛缩合产物生产连续长丝纤维的方法包括过滤高浓度的三聚氰胺 - 甲醛缩合产物，迫使滤液通过喷丝头，通过热空气干燥干燥轴中的挤出长丝，并在回火炉中处理干燥的长丝，温度逐渐升高至最高温度为160至250℃ 治愈预处理。

    Continuous method for producing amino- and/or phenoplasts
    5.
    发明授权
    Continuous method for producing amino- and/or phenoplasts 失效
    连续生产氨基和/或酚醛的方法

    公开(公告)号：US06500371B1

    公开(公告)日：2002-12-31

    申请号：US09485222

    申请日：2000-02-07

    申请人： Heinz Berbner ,  Hans Etling ,  Erhard Guenther ,  Tilman Sirch ,  Hans Dieter Zettler

    发明人： Heinz Berbner ,  Hans Etling ,  Erhard Guenther ,  Tilman Sirch ,  Hans Dieter Zettler

    IPC分类号： B29C4776

    CPC分类号： C08G14/00 ,  B29C47/00 ,  B29C47/0019 ,  B29C47/50 ,  B29C67/246 ,  B29K2061/04 ,  B29K2061/20

    摘要： The invention relates to a continuous process for preparing aminoplastics and/or phenolics, in which a precondensate solution is prepared in a first extruder (14), the precondensate solution is continuously fed, with addition of additives, to a second extruder (20) with partial filling in the feed section (E) and devolatilization section (G), devolatilized in the second extruder (20) and then formed to give a molding composition or an end product. The process is particularly suitable for preparing melamine resins, in particular melamine-formaldehyde resins, as well as for preparing urea-formaldehyde resins.

    摘要翻译： 本发明涉及一种用于制备氨基塑料和/或酚醛的连续方法，其中在第一挤出机（14）中制备预缩合溶液，将预缩合物溶液与添加剂连续加入到第二挤出机（20）中， 部分填充进料部分（E）和脱挥发段（G），在第二挤出机（20）中脱挥发分，然后形成模塑组合物或最终产物。 该方法特别适用于制备三聚氰胺树脂，特别是三聚氰胺 - 甲醛树脂，以及制备脲 - 甲醛树脂。

    Method for producing small-particle preparations of biologically active substances
    6.
    发明授权
    Method for producing small-particle preparations of biologically active substances 有权
    生物活性物质微粒制剂的制备方法

    公开(公告)号：US06318650B1

    公开(公告)日：2001-11-20

    申请号：US09424513

    申请日：1999-11-15

    申请人： Jörg Breitenbach ,  Hans Dieter Zettler

    发明人： Jörg Breitenbach ,  Hans Dieter Zettler

    IPC分类号： B02C1912

    CPC分类号： B29C47/0004 ,  A61K9/1694 ,  B29C47/0011 ,  B29C47/0871 ,  B29C47/38 ,  B29C47/402 ,  B29C47/827 ,  B29K2105/0035

    摘要： A process for the continuous production of solid, particulate preparations of bioactive substances, in which the bioactive substances are homogeneously dispersed in a matrix of thermoplastic auxiliaries, in a screw extruder divided into a plurality of zones, wherein there is firstly melting of the matrix auxiliaries and mixing of the bioactive components with the matrix auxiliaries in a heatable zone, after which the mixture is cooled, precomminuted and finely ground in a cooling zone, the screw geometry in the cooling zone being selected so that the cooling zone consists of a conveying zone, a mixing zone and a kneading zone.

    摘要翻译： 一种连续生产生物活性物质的固体颗粒制剂的方法，其中生物活性物质均匀分散在热塑性助剂基质中，分成多个区域的螺杆挤出机，其中首先熔化基质助剂 并将生物活性组分与基质助剂在可加热区中混合，之后将混合物冷却，预先稀释并在冷却区中精细研磨，选择冷却区中的螺杆几何形状使得冷却区由输送区 ，混合区和捏合区。