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公开(公告)号:US20130035358A1
公开(公告)日:2013-02-07
申请号:US13634221
申请日:2011-03-14
IPC分类号: A61K31/44 , A61P29/00 , A61P11/00 , A61P11/06 , A61P37/08 , A61P27/02 , A61P17/00 , A61P1/00 , A61P9/00 , A61P25/00 , A61P31/10 , A61P31/04 , A61P31/12 , C07D409/10 , A61K31/4436 , C07D405/10 , A61K31/443 , A61K31/4433 , C07D213/74
CPC分类号: C07D405/12 , C07D213/50 , C07D213/65 , C07D213/74 , C07D401/10 , C07D409/12
摘要: There is provided compounds of formula I, wherein E1, E2a, E2b, E2c, E4, D1, D2, D3, L1, Y1, L2 and Y2 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of a respiratory disorder and/or inflammation.
摘要翻译: 提供式I化合物,其中E1,E2a,E2b,E2c,E4,D1,D2,D3,L1,Y1,L2和Y2具有说明书中给出的含义及其药学上可接受的盐,该化合物是有用的 用于治疗期望和/或需要抑制白细胞三烯C4合酶的疾病,特别是治疗呼吸障碍和/或炎症的疾病。