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公开(公告)号：US06645938B2
公开(公告)日：2003-11-11
申请号：US09757860
申请日：2001-01-10
IPC分类号： A61K3800
摘要： A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06316411B1
公开(公告)日：2001-11-13
申请号：US09477100
申请日：2000-01-04
IPC分类号： A61K3800
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
摘要翻译： 使用该化合物以减少与哺乳动物器官如心脏的缺血和再灌注相关的损伤的化合物和方法。 该化合物可以作为预处理策略的一部分施用，其减少损伤的程度并且在停止和恢复血流之后改善器官功能。 该化合物可用于准备计划的缺血或以预防方式预期进一步的缺血事件。
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公开(公告)号：US07060792B2
公开(公告)日：2006-06-13
申请号：US11141670
申请日：2005-05-31
IPC分类号： A61K38/00
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06900178B2
公开(公告)日：2005-05-31
申请号：US09947656
申请日：2001-09-06
摘要： A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound, either Deltorphin A and/or Dermorphin H, may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
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公开(公告)号：US06294519B1
公开(公告)日：2001-09-25
申请号：US09702305
申请日：2000-10-31
申请人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
发明人： Peter R. Oeltgen , Mark S. Kindy , Paul D. Bishop
IPC分类号： A01N3718
摘要： A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 &mgr;g/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated using the method of the invention.
摘要翻译： 一种通过向哺乳动物施用去铁蛋白来治疗缺血的方法。 可以给予Deltorphin I SEQ ID NO：1，delntorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合。 在缺血发作后4小时内给药约0.5-20mg / kg体重的滴度，或者在生理上可接受的制剂中哺乳动物的约1-1000μg/ kg体重的较低浓度。 去头痛也可以在缺血发作之前或同时发生。 可以使用本发明的方法治疗脑或脊髓缺血或缺血性心脏病。
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6.发明授权Seventeen amino acid peptide (Peptide P) for treating ischemia and reperfusion injury 失效17种氨基酸肽（P肽）用于治疗缺血和再灌注损伤公开(公告)号：US06967192B2
公开(公告)日：2005-11-22
申请号：US10384650
申请日：2003-03-11
申请人： Peter R. Oeltgen , Mark S. Kindy
发明人： Peter R. Oeltgen , Mark S. Kindy
摘要： Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Ser-Ile-NH2-SEQ ID NO:1, is useful to treat ischemia.
摘要翻译： 具有氨基酸序列Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-His-Ser-Ile-NH2-SEQ ID NO：1的肽P， 可用于治疗缺血。
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7.发明授权Seventeen amino acid peptide (Peptide P) for treating ischemia and reperfusion injury 失效17种氨基酸肽（P肽）用于治疗缺血和再灌注损伤公开(公告)号：US06544950B1
公开(公告)日：2003-04-08
申请号：US10003328
申请日：2001-12-06
申请人： Peter R. Oeltgen , Mark S. Kindy
发明人： Peter R. Oeltgen , Mark S. Kindy
IPC分类号： A61K3800
摘要： Peptide P, having the amino acid sequence Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2, is useful to treat ischemia.
摘要翻译： 具有氨基酸序列Tyr-D-Ala-Phe-Ala-Asp-Val-Ala-Ser-Thr-Ile-Gly-Asp-Phe-Phe-His-Ser-Ile-NH2的肽P可用于治疗 缺血。
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8.发明授权Method for treating a viral infection related or a chemical toxin related hepatic injury with deltorphin D 失效用deltorphin D治疗病毒感染或化学毒素相关肝损伤的方法公开(公告)号：US07335642B2
公开(公告)日：2008-02-26
申请号：US11085919
申请日：2005-03-22
IPC分类号： A61K38/10 , C07K14/435
CPC分类号： A61K38/10 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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公开(公告)号：US06380164B1
公开(公告)日：2002-04-30
申请号：US09767657
申请日：2001-01-23
IPC分类号： A61K3808
CPC分类号： A61K38/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用deltorphins来调节细胞因子介导的肝损伤的方法。 Deltorphin I SEQ ID NO：1，deltorphin II SEQ ID NO：2或deltorphins I SEQ ID NO：1和II SEQ ID NO：2的组合可以施用。 在生理上可接受的制剂中，约0.5mg / kg至约20mg / kg范围内的delphphin浓度阻断脓毒性休克鼠模型中的细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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公开(公告)号：US06875742B2
公开(公告)日：2005-04-05
申请号：US09971902
申请日：2001-10-05
IPC分类号： A61K38/10 , C07K14/435
CPC分类号： A61K38/10 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/893 , Y10S514/894 , Y10S514/937
摘要： A method of modulating cytokine mediated hepatic injury by administering compound-D SEQ ID NO:1 to a mammal. A concentration of the compound in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.
摘要翻译： 通过向哺乳动物施用化合物D SEQ ID NO：1来调节细胞因子介导的肝损伤的方法。 在生理上可接受的制剂中，化合物浓度在约0.5mg / kg至约20mg / kg的范围内阻断细胞因子级联。 因此公开了调节细胞因子介导的急性炎症，创伤诱导和毒素诱导的肝损伤的治疗方法，特别是通过肿瘤坏死因子调节。
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