公开(公告)号：US06995142B2

公开(公告)日：2006-02-07

申请号：US10289982

申请日：2002-11-06

申请人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr.

发明人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr.

IPC分类号： C07K5/06

CPC分类号： C07D207/26 ,  A61K38/00 ,  C07D261/18 ,  C07D413/12 ,  C07K5/0205 ,  Y02A50/463 ,  Y02A50/465

摘要： Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

摘要翻译： 肽和肽模拟化合物的化学式为：化学式id =“CHEM-US-00001”num =“000

公开(公告)号：US06906198B1

公开(公告)日：2005-06-14

申请号：US09647712

申请日：1999-01-05

申请人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr. ,  Jayashree Girish Tikhe

发明人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr. ,  Jayashree Girish Tikhe

IPC分类号： C07D207/00 ,  C07K5/02

CPC分类号： C07K5/0205

摘要： Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

摘要翻译： 下式的肽和拟肽化合物：其中式变量如本公开所定义，有利地抑制或阻断小核糖核酸病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还提供了制备这些化合物的中间体和合成方法。

公开(公告)号：US06531452B1

公开(公告)日：2003-03-11

申请号：US09301977

申请日：1999-04-29

申请人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr.

发明人： Peter Scott Dragovich ,  Stephen Evan Webber ,  Thomas Jay Prins ,  Ru Zhou ,  Joseph Timothy Marakovits ,  Theodore O. Johnson, Jr.

IPC分类号： C07K506

CPC分类号： C07D207/26 ,  A61K38/00 ,  C07D261/18 ,  C07D413/12 ,  C07K5/0205 ,  Y02A50/463 ,  Y02A50/465

摘要： Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.

摘要翻译： 下式的肽和拟肽化合物：其中式变量如本公开所定义，有利地抑制或阻断小核糖核酸病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还提供了制备这些化合物的中间体和合成方法。

公开(公告)号：US06534530B1

公开(公告)日：2003-03-18

申请号：US09631708

申请日：2000-08-03

申请人： Peter Scott Dragovich ,  Ru Zhou ,  Stephen Evan Webber ,  Thomas J. Prins ,  Siegfried Heinz Reich ,  Susan E. Kephart ,  Yuanjin Rui

发明人： Peter Scott Dragovich ,  Ru Zhou ,  Stephen Evan Webber ,  Thomas J. Prins ,  Siegfried Heinz Reich ,  Susan E. Kephart ,  Yuanjin Rui

IPC分类号： A61K31427

CPC分类号： C07K5/06043 ,  A61K38/00 ,  C07K5/06191 ,  C07K5/0821 ,  C07K5/0827 ,  Y02A50/463 ,  Y02A50/465

摘要： Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.

摘要翻译： 下式的化合物：其中式变量如本公开所定义，有利地抑制或阻断小核糖核蛋白病毒3C蛋白酶的生物学活性。 这些化合物以及含有这些化合物的药物组合物可用于治疗感染一种或多种微小核糖核酸病毒如RVP的患者或宿主。 还描述了制备这些化合物的中间体和合成方法。

公开(公告)号：US07115658B2

公开(公告)日：2006-10-03

申请号：US10434702

申请日：2003-05-09

申请人： Allen J. Borchardt ,  Peter Scott Dragovich ,  Javier Gonzalez ,  Tanya Michelle Jewell ,  Hui Li ,  Maria Angelica Linton ,  John Howard Tatlock ,  Ru Zhou ,  Thomas Jay Prins ,  Melwyn A. Abreo

发明人： Allen J. Borchardt ,  Peter Scott Dragovich ,  Javier Gonzalez ,  Tanya Michelle Jewell ,  Hui Li ,  Maria Angelica Linton ,  John Howard Tatlock ,  Ru Zhou ,  Thomas Jay Prins ,  Melwyn A. Abreo

IPC分类号： A61K31/351

CPC分类号： C07D405/06 ,  C07D309/32 ,  C07D405/12 ,  C07D407/06 ,  C07D413/12 ,  C07D417/06 ,  C07D487/04

摘要： Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus

摘要翻译： 式I化合物为丙型肝炎病毒（HCV）RNA依赖性RNA聚合酶（RdRp）抑制剂，可用于丙型肝炎病毒感染者的治疗和预防性治疗