公开(公告)号：US06562330B1

公开(公告)日：2003-05-13

申请号：US09831750

申请日：2001-05-14

申请人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

发明人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

IPC分类号： A61K3174

CPC分类号： A61K49/04

摘要： An insoluble polymer is deposited in a body cavity for instance to embolize a vein or pack an aneurysm, the polymer having pendant zwitterionic groups to improve biocompatibility. The insoluble polymer is preferably formed by an in situ gelling step in which a charged, preferably soluble, polymer having pendant zwitterionic groups is introduced in the form of a composition in which it is soluble and is gelled by being mixed with a counterionically charged soluble polymer (polyelectrolyte), to form a polyion complex. Preferably the or each soluble polymer is formed by polymerizing ethylenically unsatured monomers including a zwitterionic monomer, for instance 2-methacryloyloxyethyl-2′-trimethylammoniumethyl phosphate inner salt, an ionic monomer such as trimethylammonium alkyl(alk)acrylate or a sulphoalkyl(alk)acrylate and optionally a diluent monomer such as an alkyl(alk)acrylate.

摘要翻译： 将不溶性聚合物沉积在体腔中，例如栓塞静脉或包装动脉瘤，所述聚合物具有侧基两性离子基团以改善生物相容性。 不溶性聚合物优选通过原位胶凝步骤形成，其中具有侧链两性离子基团的带电的，优选可溶的聚合物以组合物的形式引入，其中它是可溶的，并且通过与抗衡离子电荷的可溶性聚合物 （聚电解质），形成聚离子络合物。 优选地，每种可溶性聚合物通过聚合包含两性离子单体的烯属不成熟单体，例如2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸内盐，离子单体如烷基（alk）丙烯酸三甲基铵或磺酸烷基（alk）丙烯酸酯 和任选的稀释剂单体如烷基（alk）丙烯酸酯。

公开(公告)号：US06524569B1

公开(公告)日：2003-02-25

申请号：US09831753

申请日：2001-05-14

申请人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

发明人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

IPC分类号： A61K3174

CPC分类号： C08K9/12 ,  C08L57/04 ,  C08L57/12 ,  C08L2666/04

摘要： A polyion complex (PIC) is formed of an anionic soluble polymer formed from ethylenically unsaturated monomers including at least one anionic or monomer and a cationic soluble polymer formed from ethylenically unsaturated monomer including at least one cationic monomer, in which the monomers used to form at least one of the polymers comprise a zwitterionic monomer and in which the monomers used to form at least one of the polymers include non-ionic monomer, preferably C1-24 alkyl(meth)acrylate, in which the overall ratio of anionic groups to cationic groups in the PIC is in the range 1.5:1 to 1:1.5, and in which the polymers are combined in ratios to provide a PIC in which there are units derived from zwitterionic monomer in an amount in the range 1 to 70 mole % based on total monomer derived units in the PIC and there are units derived from non-ionic monomer in an amount in the range 0 to 60 mole % based on total monomer derived units in the PIC. The PIC is preferably swollen in water and is a flowable gel. The zwitterionic monomer is preferably 2-(methacyloyloxyethyl)-2′-(trimethylammoniumethyl)phosphate inner salt.

摘要翻译： 聚阴离子络合物（PIC）由阴离子可溶性聚合物形成，其由包含至少一种阴离子或单体的烯属不饱和单体和由包含至少一种阳离子单体的烯属不饱和单体形成的阳离子可溶性聚合物形成，其中用于在 至少一种聚合物包含两性离子单体，其中用于形成至少一种聚合物的单体包括非离子单体，优选C 1-4烷基（甲基）丙烯酸酯，其中阴离子基团与阳离子基团的总比例 在PIC中的范围为1.5:1至1:1.5，其中聚合物的比例组合以提供PIC，其中存在衍生自两性离子单体的单元，其量为1至70摩尔％，基于 PIC中的单体衍生单元总数，并且源自非离子单体的单元的量为基于PIC中单体衍生单元的0至60摩尔％。 PIC优选在水中溶胀并且是可流动的凝胶。 两性离子单体优选为2-（甲基氰基乙氧基乙基）-2' - （三甲基铵乙基）磷酸酯内盐。

公开(公告)号：US07064174B2

公开(公告)日：2006-06-20

申请号：US10203203

申请日：2001-02-07

申请人： Andrew Lennard Lewis ,  Anthony Claude Marie Collias ,  Richard Paul Redman ,  Jane Louise Court ,  Sean Leo Willis

发明人： Andrew Lennard Lewis ,  Anthony Claude Marie Collias ,  Richard Paul Redman ,  Jane Louise Court ,  Sean Leo Willis

IPC分类号： C08G77/26

CPC分类号： C08L83/08 ,  C07F7/0838 ,  C07F9/091 ,  C08G77/388 ,  C08G77/392 ,  C08G77/395 ,  Y10T428/1457 ,  Y10T428/249969 ,  Y10T428/31663

摘要： A silicon containing adduct having the formula (I) wherein X is an electron withdrawing group selected from the group consisting of carbonyl and sulphone groups, sulphonium and phosphonium salts; R is selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, di-alkylaminoalkyl, N-aryl-N-alky-laminoalkyl, hydroxyalkoxy, alkoxy, alkenyloxy, alkynyloxy, cycloalkoxy, cycloalkenyloxy, cycloalkynyloxy, aralkoxy, alkoxyaryloxy, alkoxyalkoxy, oligoalkoxyalkoxy, di-alkylaminoalkoxy, N-aryl-N-alkylamino-alkoxy, acyloxy, acyloxyalkyl, N-diacyl-iminoalkyl groups, organosilane, organosiloxane, hydroxyaryl, hydroxyalkenyl, hydroxyalkynyl and hydroxy groups and any of the above groups substituted with one or more hydroxyl or xzwitterionic group Z, or R—X— is a nitrile group; R3 and R4 are individually selected from the group consisting of hydrogen, linear and branched alkyl, alkenyl, and alkynyl groups, aryl, alkoxycarbonyl, alkylaminocarbonyl, cycloalkyl, cycloalkenyl, cycloalkynyl, haloaryl, haloalkyl, alkaryl, aralkyl, alkoxyaryl, alkoxyalkyl, oligoalkoxyalkyl, aminoalkyl, mono- and di-alkylaminoalkyl, arylaminoalkyl, N-aryl-N-alkylaminoalkyl and -aminoaryl, acyloxy, acyloxyalkyl, acylaminoalkyl, N-diacyl-iminoalkyl groups, alkylaminocarbonyl, oxacycloalkyl, oxacycloalkenyl, organosilane and organosiloxane groups and any of the above groups substituted with a zwitterionic group Z, a hydroxyl group or an isocyanate group; R1 and R2 are individually selected from hydrogen and C1-12 alkyl groups; and at least one of groups R, R3, and R4 contain an organosiloxane group Y and/or an organosilane group U. The invention additionally provides processes for the production of such an adduct, polymers formed therefrom, coating processes and compositions comprising an adduct or polymers produced therefrom