公开(公告)号：US20220119545A1

公开(公告)日：2022-04-21

申请号：US17292257

申请日：2019-11-07

Applicant: Beth Israel Deaconess Medical Center ,  Pfizer Inc. ,  Cornell University

Inventor： Lewis C. CANTLEY ,  Stephen P. SOLTOFF ,  Brooke M. EMERLING ,  George POULOGIANNIS ,  Cindy M. HODAKOSKI ,  Hui LIU ,  Irina APOSTOLOU ,  Brian Gaither BATES ,  Kimberly Ann MARQUETTE ,  Eric M. BENNETT ,  Lidia MOSYAK ,  Lioudmila G. TCHISTIAKOVA ,  Edward Christian ROSFJORD ,  Isaac J. RONDON ,  Chao Bai HUANG

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure provides materials and methods for CUB domain-containing protein 1 (CDCP1)-targeted therapy.

公开(公告)号：US20200069764A1

公开(公告)日：2020-03-05

申请号：US16688173

申请日：2019-11-19

Applicant: Pfizer Inc.

Inventor： Dangshe MA ,  Kimberly Ann MARQUETTE ,  Edmund Idris GRAZIANI ,  Puja SAPRA ,  Lawrence Nathan TUMEY ,  Nadira Anarkali PRASHAD ,  Kiran Manohar KHANDKE ,  Eric M. BENNETT ,  Lioudmila TCHISTIAKOVA

IPC: A61K38/05 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.

公开(公告)号：US20170216452A1

公开(公告)日：2017-08-03

申请号：US15356953

申请日：2016-11-21

Applicant: Pfizer Inc.

Inventor： Dangshe MA ,  Kimberly Ann MARQUETTE ,  Edmund Idris GRAZIANI ,  Puja SAPRA ,  Lawrence Nathan TUMEY ,  Nadira Anarkali PRASHAD ,  Kiran Manohar KHANDKE ,  Eric M. BENNETT ,  Lioudmila TCHISTIAKOVA

IPC: A61K51/10 ,  C07K16/28 ,  C07K16/32 ,  A61K38/05 ,  C07K19/00 ,  A61K48/00 ,  A61K47/48

CPC classification number: A61K38/05 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  C07K16/283 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.